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Pilot Trial of N-acetylcysteine and Tigecycline as a Catheter-Lock Solution for Treatment of Hemodialysis Catheter–Associated Bacteremia

Published online by Cambridge University Press:  02 January 2015

Saima Aslam ,
Barbara W. Trautner ,
Venkat Ramanathan  and
Rabih O. Darouiche
Saima Aslam*
Affiliation:
Sections of Infectious Disease, Houston, Texas Baylor College of Medicine, and the Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas
Barbara W. Trautner
Affiliation:
Sections of Infectious Disease, Houston, Texas Baylor College of Medicine, and the Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas
Venkat Ramanathan
Affiliation:
Nephrology, Houston, Texas Baylor College of Medicine, and the Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas
Rabih O. Darouiche
Affiliation:
Sections of Infectious Disease, Houston, Texas Department of Medicine, and the Center for Prostheses Infection, Houston, Texas Baylor College of Medicine, and the Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas
*
2002 Holcombe Blvd., Room 4B-370, Section of Infectious Disease, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX 77030 ([email protected])
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Abstract

We evaluated a catheter-lock solution consisting of N-acetylcysteine, tigecycline, and heparin for catheter salvage in patients with hemodialysis catheter-associated bacteremia. Eighteen case patients received the catheter-lock solution for 14 days plus systemic antibiotic therapy. Treatment was successful for 15 (83%) of the 18 case patients within 90 days of follow-up, with a median catheter retention interval of 64.5 days.

Trial registration. ClinicalTrials.gov identifier: NCT00614679.

Type
Concise Communication
Information
Infection Control & Hospital Epidemiology , Volume 29 , Issue 9 , September 2008 , pp. 894 - 897
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2008

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References

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