Hostname: page-component-cd9895bd7-8ctnn Total loading time: 0 Render date: 2024-12-26T22:06:40.021Z Has data issue: false hasContentIssue false
  • English
  • Français

Outbreak of Carbapenem-Resistant Providencia stuartii in an Intensive Care Unit

Published online by Cambridge University Press:  02 January 2015

Alexandre P. Zavascki ,
Cecília G. Carvalhaes ,
Geórgia L. da Silva ,
Sílvia Pedroso Tavares Soares ,
Luciana R. de Alcåntara ,
Laura S. Elias ,
Ana M. Sandri  and
Ana C. Gales
Alexandre P. Zavascki*
Affiliation:
Infectious Diseases Service, Hospital de Clínicas de Porto Alegre, Brazil
Cecília G. Carvalhaes
Affiliation:
Laboratório ALERTA, Division of Infectious Diseases, Universidade Federal de São Paulo, São Paulo, Brazil
Geórgia L. da Silva
Affiliation:
Infection Control Service, Hospital São Lucas da Pontificia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil
Sílvia Pedroso Tavares Soares
Affiliation:
Infection Control Service, Hospital São Lucas da Pontificia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil
Luciana R. de Alcåntara
Affiliation:
Infection Control Service, Hospital São Lucas da Pontificia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil
Laura S. Elias
Affiliation:
Infection Control Service, Hospital São Lucas da Pontificia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil
Ana M. Sandri
Affiliation:
Infection Control Service, Hospital São Lucas da Pontificia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil
Ana C. Gales
Affiliation:
Laboratório ALERTA, Division of Infectious Diseases, Universidade Federal de São Paulo, São Paulo, Brazil
*
Alexandre P. Zavascki, MD, PhD, Infectious Diseases Service, Hospital de Clínicas de Porto Alegre, 2350 Ramiro Barcelos Street, Porto Alegre 90.035-903, Brazil ([email protected])
Get access Rights & Permissions [Opens in a new window]

Abstract

Outbreaks by carbapenem-resistant Providencia stuartii (CRPS) are rarely described. Clinical characteristics of patients with CRPS in an intensive care unit and resistance mechanisms were investigated. Carbapenemase production and/or outer membrane alterations were not detected; only CTX-M-2 and AmpC hyperproduction were noted. The outbreak was ultimately controlled in a 3-month period.

Type
Concise Communication
Information
Infection Control & Hospital Epidemiology , Volume 33 , Issue 6 , June 2012 , pp. 627 - 630
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2012 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Lee, HW, Kang, HY, Shin, KS, Kim, J. Multidrug-resistant Providencia isolates carrying blaPER-1, blaVIM-2, and armA. J Microbiol 2007;45:272–274.Google Scholar
2. Miriagou, V, Tzouvelekis, LS, Flevari, K, Tsakiri, M, Douzinas, EE. Providencia stuartii with VIM-1 metallo-β-lactamase. J Anti-microb Chemother 2007;60:183–184.Google Scholar
3. Shiroto, K, Ishii, Y, Kimura, S, et al. Metallo-β-lactamase IMP-1 in Providencia rettgeri from two different hospitals in Japan. J Med Microbiol 2005;54:1065–1070.Google Scholar
4. Horan, TC, Andrus, M, Dudeck, MA. CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control 2008;36:309–332.Google Scholar
5. Clinical and Laboratory Standards Institute. 2009. Performance standards for antimicrobial susceptibility testing. CLSI document M100-S19. Clinical and Laboratory Standards Institute, Wayne, PA.Google Scholar
6. Thomson, KS. Extended-spectrum-β-lactamase, AmpC, and car-bapenemase issues. J Clin Microbiol 2010;48:1019–1025.Google Scholar
7. Tenover, FC, Arbeit, RD, Goering, RV, et al. Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J Clin Microbiol 1995;33:2233–2239.Google Scholar
8. Poirel, L, Naas, T, Guibert, M, EB, Chaibi, Labia, R, Nordmann, P. Molecular and biochemical characterization of VEB-1, a novel class A extended-spectrum β-lactamase encoded by an Escherichia coli integran gene. Antimicrob Agents Chemother 1999;43: 573–581.Google Scholar
9. Picão, RC, Poirel, L, Gales, AC, Nordmann, P. Diversity of β-lactamases produced by ceftazidime-resistant Pseudomonas aeru ginosa causing bloodstream infections in Brazil. Antimicrob Agents Chemother 2009;53:3908–3913.Google Scholar
10. Pérez-Pérez, FJ, Hanson, ND. Detection of plasmid-mediated AmpC β-lactamase genes in clinical isolates by using multiplex PCR. J Clin Microbiol 2002;40:2153–2162.Google Scholar
11. Hernandez-Allés, S, Albertí, S, Alvarez, D, et al. Porin expression in clinical isolates of Klebsiella pneumoniae . Microbiology 1999; 145:673–679.Google Scholar
12. Tran, QT, Mahendran, KR, Hajjar, E, et al. Implication of porins in β-lactam resistance of Providencia stuartii . J Biol Chem 2010; 285:32273–32281.Google Scholar