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New Definitions Will Help, but Cultures are Critical for Resolving Unanswered Questions About Clostridium difficile

Published online by Cambridge University Press:  02 January 2015

Dale N. Gerding*
Affiliation:
Edward Hines, Jr., Veterans Administration Hospital, Hines, Illinois, and the Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois
*
ACOS/Research and Development, Hines VA Hospital, 5th Avenue and Roosevelt Road, Bldg 1, Rm C344, Hines, IL 60141 ([email protected])
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Abstract

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Type
Editorial
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2007

References

1.McDonald, LC, Owings, M, Jernigan, DB. Clostridium difficile infection in patients discharged from US short-stay hospitals, 1996-2003. Emerglnfect Dis 2006;12:409415.Google ScholarPubMed
2.Chandler, RE, Hedberg, K, Cieslak, PR. Clostridium difficile-associated Disease in Oregon: increasing incidence and hospital-level risk factors. Infect Control Hosp Epidemiol 2007;28:116122 (in this issue).Google Scholar
3.McDonald, LC, Killgore, GE, Thompson, A, et al. An epidemic, toxin gene-variant strain of Clostridium difficile. N Engl J Med 2005;353:24332441.Google Scholar
4.Loo, VG, Poirier, L, Miller, MA, et al. A predominantly clonal multi-institutional outbreak of Clostridium-difficile-associated diarrhea with high morbidity and mortality. N Engl J Med 2005;353:24422449.Google Scholar
5.Hubert, B, Loo, VG, Bourgault, A-M, et al. A portrait of the geographic dissemination of the Clostridium difficile North American pulsed-field type 1 strain and epidemiology of C. difficile-associated disease in Quebec. Clin Infect Dis 2007;44:238244.Google Scholar
6.Delmee, M, Van Broeck, J, Simon, A, Janssens, M, Avesani, V. Laboratory diagnosis of Clostridium difficile-associated diarrhoea: a plea for culture. J Med Microbiol 2005;54:187191.CrossRefGoogle ScholarPubMed
7.Shanholtzer, CJ, Willard, KE, Holter, JJ, Olson, MM, Gerding, DN, Peterson, LR. Comparison of the VIDAS Clostridium difficile toxin A immunoassay with C. difficile culture and cytotoxin and Latex tests. J Clin Microbiol 1992;30:18371840.Google Scholar
8.O'Connor, D, Hynes, P, Cormican, M, Collins, E, Corbett-Feeney, G, Cassidy, M. Evaluation of methods for detection of toxins in specimens of feces submitted for diagnosis of Clostridium difficile-associated diarrhea. J Clin Microbiol 2001;39:28462849.CrossRefGoogle ScholarPubMed
9.Johnson, S, Kent, SA, O'Leary, KJ, et al. Fatal pseudomembranous colitis associated with a variant Clostridium difficile strain not detected by toxin A immunoassay. Ann Intern Med 2001;135:434438.Google Scholar
10.Biller, P, Shank, B, Lind, L, et al. Moxifloxacin therapy as a risk factor for Clostridium difficile-associated disease during an outbreak: attempts to control a new epidemic strain. Infect Control Hosp Epidemiol 2007;28:198201 (in this issue).CrossRefGoogle ScholarPubMed
11.Lawrence, SJ, Puzniak, LA, Shadel, BN, Gillespie, KN, Kollef, MH, Mundy, LM. Clostridium difficile in the intensive care unit: epidemiology, costs, and colonization pressure. Infect Control Hosp Epidemiol 2007;28:123130 (in this issue).Google Scholar
12.Bonten, MJ, Slaughter, S, Ambergen, AW, et al. The role of “colonization pressure” in the spread of vancomycin-resistant enterococci: an important infection control variable. Arch Intern Med 1998;158:11271132.CrossRefGoogle ScholarPubMed
13.Merrer, J, Santoli, F, Appere-De Vecchi, C, Tran, B, De Jonghe, B, Outin, H. “Colonization pressure”' and risk of acquisition of methicillin-resis-tant Staphylococcus aureus in a medical intensive care unit. Infect Control Hosp Epidemiol 2000;21:718723.Google Scholar
14.Barbut, F, Gariazzo, B, Bonnet, L, et al. Clinical features of Clostridium difficile-associated infections and molecular characterization of strains: results of a retrospective study, 2000-2004. Infect Control Hosp Epidemiol 2007;28:131139 (in this issue).Google Scholar
15.McDonald, LC, Coignard, B, Dubberke, E, et al. Recommendations for surveillance of Clostridium difficile-associated disease. Infect Control Hosp Epidemiol 2007;28:140145 (in this issue).CrossRefGoogle ScholarPubMed
16.Ticehurst, JR, Aird, DZ, Dam, LM, Borek, AP, Hargrove, JT, Carroll, KC. Effective detection of toxigenic Clostridium difficile by a two-step algorithm including tests for antigen and cytotoxin. J Clin Microbiol 2006;44:11451149.CrossRefGoogle ScholarPubMed
17.Polgreen, PM, Chen, YY, Cavanaugh, JE, et al. An outbreak of severe Clostridium difficile-associated disease possibly related to inappropriate antimicrobial therapy for community-acquired pneumonia. Infect Control Hosp Epidemiol 2007;28:212214 (in this issue).CrossRefGoogle ScholarPubMed