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Mupirocin for Controlling Methicillin-Resistant Staphylococcus Aureus: Lessons From a Decade of Use at a University Hospital

Published online by Cambridge University Press:  21 June 2016

Adriana M. Vivoni ,
Kátia R. N. Santos ,
Márcia P. de-Oliveira ,
Marcia Giambiagi-deMarval ,
Adriana L. P. Ferreira ,
Lee W. Riley  and
Beatriz M. Moreira
Adriana M. Vivoni
Affiliation:
Instituto de Microbiologia Professor Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
Kátia R. N. Santos
Affiliation:
Instituto de Microbiologia Professor Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
Márcia P. de-Oliveira
Affiliation:
Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
Marcia Giambiagi-deMarval
Affiliation:
Instituto de Microbiologia Professor Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
Adriana L. P. Ferreira
Affiliation:
Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
Lee W. Riley
Affiliation:
School of Public Health, University of California, Berkeley, California
Beatriz M. Moreira*
Affiliation:
Instituto de Microbiologia Professor Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
*
Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, Centro de Cièncias Da Saúde, Bloco I, sala 12-28, Cidade Universitária, Rio de Janeiro, RJ 21941-590, Brazil.[email protected]
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Abstract

Background:

From 1990 to 1995 at Hospital Universitario dementino Fraga Filho, patients colonized or infected with methicillin-resistant Staphylococcus aureus (MRSA) were treated with mupirocin to eliminate MRSA carriage. In 1995, 65% of MRSA patients at this hospital had mupirocin-resistant isolates. Starting in 1996, mupirocin use was restricted to patients colonized, but not infected, with MRSA.

Objectives:

To describe the use of mupirocin for controlling MRSA over a decade and to analyze the molecular epidemiology of mupirocin-resistant MRSA infections at this hospital.

Setting:

A 490-bed, tertiary-care university hospital.

Methods:

The incidence densities of patients with MRSA and acquisition of mupirocin by the hospital were calculated for the period 1992–2001. S. aureus isolates from 1999–2000 were analyzed by pulsed-field gel electrophoresis. Mupirocin-resistant MRSA isolates from 1994–1995 and 1999–2000 were analyzed for ileS-2 gene background polymorphisms.

Results:

The incidence density of MRSA patients increased slightly over time, whereas the purchase of mupirocin decreased dramatically. Mupirocin-resistant MRSA infections decreased from 65% in 1994–1995 to 15% in 1999–2000. The MRSA Brazilian clone, detected in 1992, was still highly prevalent. The same ileS-2 encoding plasmid found in 1994–1995 persisted in three identical MRSA isolates from 1999–2000 belonging to the Brazilian clone.

Conclusions:

After mupirocin use decreased, the ileS-2 encoding plasmid persisted in only a few Brazilian clone isolates. Our data on mupirocin-resistant MRSA incidence and mupirocin use strongly suggested that restricted use was related to decreased rates of mupirocin resistance at our hospital. (Infect Control Hosp Epidemiol 2005;26:662-667)

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 26 , Issue 7 , July 2005 , pp. 662 - 667
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2005

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