Hostname: page-component-586b7cd67f-dlnhk Total loading time: 0 Render date: 2024-11-30T20:22:57.251Z Has data issue: false hasContentIssue false

Multiresistant Extended-Spectrum β-Lactamase-Producing Klebsiella pneumoniae Causing an Outbreak of Nosocomial Bloodstream Infection

Published online by Cambridge University Press:  02 January 2015

Artemio Gonzalez-Vertiz
Affiliation:
Epidemiology Surveillance Department, School of Medicine, UNAM, Mexico City, México
Dolores Alcantar-Curiel
Affiliation:
Department of Experimental Medicine, School of Medicine, UNAM, Mexico City, México
Marcela Cuauhtli
Affiliation:
Epidemiology Surveillance Department, School of Medicine, UNAM, Mexico City, México
Carlos Daza
Affiliation:
Department of Experimental Medicine, School of Medicine, UNAM, Mexico City, México
Catalina Gayosso
Affiliation:
Department of Experimental Medicine, School of Medicine, UNAM, Mexico City, México
Graciela Solache
Affiliation:
Epidemiology Surveillance Department, School of Medicine, UNAM, Mexico City, México
Cruz Horta
Affiliation:
Pediatric Service, School of Medicine, UNAM, Mexico City, México
Francisco Mejia
Affiliation:
Pediatric Service, School of Medicine, UNAM, Mexico City, México
Jose I. Santos
Affiliation:
Department of Experimental Medicine, School of Medicine, UNAM, Mexico City, México
Celia Alpuche-Aranda*
Affiliation:
Department of Experimental Medicine, School of Medicine, UNAM, Mexico City, México
*
Experimental Medicine Department, National University of Mexico-Mexico City General Hospital, Dr Balmis 148, 06726 México D.F

Abstract

This article describes an outbreak of bloodstream infection due to clonal dissemination of multiresistant Klebsiella pneumoniae in a neonatal area, during August 1999, in México City General Hospital. The intestinal tract was the likely reservoir, and intensification of Contact Precaution measures contained the outbreak.

Type
Concise Communications
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2001

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Eisenstein, BI, Zaleznic, DF. Enterobacteriaceae. In: Principles and Practice of Infectious Diseases. 5th ed. Sidup, Kent, UK: Churchill Livingstone; 2000:22942310.Google Scholar
2.Jacoby, GA. Extended-spectrum β-lactamases and other enzymes provided resistance to oxyimino-β-lactams. Infect Dis Clin North Am 1997;11:875887.Google Scholar
3.Rice, LB, Willey, SH, Papanicolaou, GA, Medeiros, AA, Eliopoulos, GM, Moellering, RC Jr, et al.Outbreak of ceftazidime resistance caused by extended-spectrum β-lactamases at a Massachusetts chronic-care facility. Antimicrob Agents Chemother 1990;34:21932199.Google Scholar
4.Ríos-Martinez, C, Guerrero-Camacho, A, Machuca-Becerril, O, Miranda-Novales, G, Solorzano-Santos, F, Reyes-Vega, S, et al.Brote por Klebsiella pneumoniae multirresistente en una unidad de cuidados neonatales. Análisis epidemiológico y molecular. In: Program and Abstracts of the 25th Congreso Anual de la Asociación Mexicana de Infectología y Microbiología Clínica; León, Guanajuato, Mexico; June 28-July 1, 2000. Abstract 159.Google Scholar
5.Garner, JS, Jarvis, WR, Emori, TG, Horan, TC, Hughes, JM. CDC definitions for nosocomial infections. In: Olmsted, RN, ed. APIC Infection Control and Applied Epidemiology: Principles and Practices. St. Louis, MO: Mosby; 1996:A1A20.Google Scholar
6.National Committee for Clinical Laboratory Standards 2000. Methods for Dilution Antimicrobial Susceptibility Test for Bacteria That Grow Aerobically. 5th ed. Wayne, PA: National Committee for Clinical Laboratory Standards; 2000.Google Scholar
7.Goering, R. Molecular epidemiology of nosocomial infection: analysis of chromosomal restriction fragment patterns by pulsed-field gel electrophoresis. Infect Control Hosp Epidemiol 1993;14:595600.Google Scholar
8.Miller, JH. Experiments in Molecular Genetics. New York, NY: Cold Spring Harbor Laboratory; 1972:387.Google Scholar
9.Mathew, M, Harris, AM, Marshall, MJ, Ross, GW. The use of analytical isoelectric focusing for detection and identification of β-lactamases. J Gen Microbiol 1975;88:169178.CrossRefGoogle ScholarPubMed
10.Jarvis, WR. The epidemiology of colonization. Infect Control Hosp Epidemiol 1996;17:4752.CrossRefGoogle ScholarPubMed
11.Silva, J, Aguilar, C, Ayala, G, Estrada, MA, Garze-Ramos, U, Lara-Lemus, R, et al.TLA-1: a new plasmid-mediated extended-spectrum β-lactamase from Escherichia coli. Antimicrob Agents Chemother 2000;44:9971003.CrossRefGoogle ScholarPubMed
12.Winokur, PL, Canton, R, Casellas, JM, Legakis, N. Variations in the prevalence of strains expressing an extended spectrum β-lactamase phenotype and characterization of isolates from Europe, the Americas and the Western Pacific Region. Clin Infect Dis 2001;32(suppl 2):S94S103.Google Scholar