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Multidrug-Resistant Acinetobacter baumannii Infection, Colonization, and Transmission Related to a Long-Term Care Facility Providing Subacute Care

Published online by Cambridge University Press:  10 May 2016

Eva Mortensen ,
Kavita K. Trivedi ,
Jon Rosenberg ,
Sara H. Cody ,
Janet Long ,
Bette J. Jensen  and
Duc J. Vugia
Eva Mortensen
Affiliation:
Division of Communicable Disease Control, Center for Infectious Diseases, California Department of Public Health, Richmond, California Epidemic Intelligence Service, Scientific Education and Professional Development Program Office, Centers for Disease Control and Prevention, Atlanta, Georgia
Kavita K. Trivedi
Affiliation:
Healthcare Associated Infections Program, Center for Health Care Quality, California Department of Public Health, Richmond, California
Jon Rosenberg
Affiliation:
Healthcare Associated Infections Program, Center for Health Care Quality, California Department of Public Health, Richmond, California
Sara H. Cody
Affiliation:
Santa Clara County Public Health Department, San Jose, California
Janet Long
Affiliation:
John Muir Health, Concord, California
Bette J. Jensen
Affiliation:
Division of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia
Duc J. Vugia*
Affiliation:
Division of Communicable Disease Control, Center for Infectious Diseases, California Department of Public Health, Richmond, California
*
Infectious Diseases Branch, 850 Marina Bay Parkway, Building P, 2nd Floor, Richmond, CA 94804 ([email protected])
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Abstract

Objective.

To investigate Acinetobacter baumannii infection, colonization, and transmission related to a long-term care facility (LTCF) providing subacute care (facility A).

Methods.

We reviewed facility A and affiliated local hospital records for facility A residents with A. baumannii isolated during the period January 2009 through February 2010 and compared A. baumannii antimicrobial resistance patterns of residents with those of hospital patients. During March 2010, we implemented a colonization survey of facility A residents who received respiratory support or who could provide sputum samples and looked for A. baumannii colonization risks. Available clinical and survey isolates underwent pulsed-field gel electrophoresis (PFGE); PFGE strains were linked with overlapping stays to identify possible transmission.

Results.

During the period January 2009 through February 2010, 33 facility A residents had A. baumannii isolates; all strains were multidrug resistant (MDR), which was a significantly higher prevalence of MDR strains than that found among isolates from hospital patients (81 [66%] of 122 hospital patient isolates were MDR; P < .001). The sputum survey found that 14 (20%) of 70 residents had A. baumannii colonization, which was associated with ventilator use (adjusted odds ratio, 4.24 [95% confidence interval, 1.06–16.93]); 12 (86%) of 14 isolates were MDR. Four facility A resident groups clustered with 3 PFGE strains and overlapping stays. One of these facility A residents also clustered with 3 patients at an affiliated hospital.

Conclusions.

We documented substantial MDR A. baumannii infections and colonization with probable intra- and interfacility spread associated with a single LTCF providing subacute care. Given the limited infection prevention and antimicrobial stewardship resources in such settings, regional collaborations among facilities across the spectrum of health care are needed to address this MDR threat.

Type
Original Article
Information
Infection Control & Hospital Epidemiology , Volume 35 , Issue 4: Special Topic Issue: Carbapenem-Resistant Enterobacteriaceae and Multidrug-Resistant Organisms , April 2014 , pp. 406 - 411
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2014

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