Hostname: page-component-6bf8c574d5-nvqbz Total loading time: 0 Render date: 2025-03-03T17:44:03.340Z Has data issue: false hasContentIssue false
  • English
  • Français

Incidence of Extended-Spectrum β-Lactamase (ESBL)-Producing Escherichia coli and Klebsiella Infections in the United States: A Systematic Literature Review

Published online by Cambridge University Press:  31 July 2017

Jennifer McDanel ,
Marin Schweizer ,
Victoria Crabb ,
Richard Nelson ,
Matthew Samore ,
Karim Khader ,
Amy E. Blevins ,
Daniel Diekema ,
Hsiu-Yin Chiang  and
Rajeshwari Nair
...Show all authors
Jennifer McDanel*
Affiliation:
Department of Internal Medicine, University of Iowa, Iowa City, Iowa Iowa City Veteran Affairs Medical Center, Iowa City, Iowa Department of Epidemiology, University of Iowa, Iowa City, Iowa
Marin Schweizer
Affiliation:
Department of Internal Medicine, University of Iowa, Iowa City, Iowa Iowa City Veteran Affairs Medical Center, Iowa City, Iowa Department of Epidemiology, University of Iowa, Iowa City, Iowa
Victoria Crabb
Affiliation:
Iowa City Veteran Affairs Medical Center, Iowa City, Iowa Department of Epidemiology, University of Iowa, Iowa City, Iowa
Richard Nelson
Affiliation:
Department of Clinical Epidemiology, University of Utah, Salt Lake City, Utah Veterans Affairs Salt Lake City Health Care System, Salt Lake City, Utah
Matthew Samore
Affiliation:
Department of Clinical Epidemiology, University of Utah, Salt Lake City, Utah Veterans Affairs Salt Lake City Health Care System, Salt Lake City, Utah
Karim Khader
Affiliation:
Department of Clinical Epidemiology, University of Utah, Salt Lake City, Utah Veterans Affairs Salt Lake City Health Care System, Salt Lake City, Utah
Amy E. Blevins
Affiliation:
Hardin Library for the Health Sciences, University of Iowa, Iowa City, Iowa.
Daniel Diekema
Affiliation:
Department of Internal Medicine, University of Iowa, Iowa City, Iowa
Hsiu-Yin Chiang
Affiliation:
Department of Internal Medicine, University of Iowa, Iowa City, Iowa
Rajeshwari Nair
Affiliation:
Department of Internal Medicine, University of Iowa, Iowa City, Iowa Iowa City Veteran Affairs Medical Center, Iowa City, Iowa
Eli Perencevich
Affiliation:
Department of Internal Medicine, University of Iowa, Iowa City, Iowa Iowa City Veteran Affairs Medical Center, Iowa City, Iowa Department of Epidemiology, University of Iowa, Iowa City, Iowa
*
Address correspondence to Jennifer McDanel, MS, PhD, 200 Hawkins Dr, C52-J GH, Iowa City, IA 52242 ([email protected]).
Get access Rights & Permissions [Opens in a new window]

Abstract

BACKGROUND

Despite a reported worldwide increase, the incidence of extended-spectrum β-lactamase (ESBL) Escherichia coli and Klebsiella infections in the United States is unknown. Understanding the incidence and trends of ESBL infections will aid in directing research and prevention efforts.

OBJECTIVE

To perform a literature review to identify the incidence of ESBL-producing E. coli and Klebsiella infections in the United States.

DESIGN

Systematic literature review.

METHODS

MEDLINE via Ovid, CINAHL, Cochrane library, NHS Economic Evaluation Database, Web of Science, and Scopus were searched for multicenter (≥2 sites), US studies published between 2000 and 2015 that evaluated the incidence of ESBL-E. coli or ESBL-Klebsiella infections. We excluded studies that examined resistance rates alone or did not have a denominator that included uninfected patients such as patient days, device days, number of admissions, or number of discharges. Additionally, articles that were not written in English, contained duplicated data, or pertained to ESBL organisms from food, animals, or the environment were excluded.

RESULTS

Among 51,419 studies examined, 9 were included for review. Incidence rates differed by patient population, time, and ESBL definition and ranged from 0 infections per 100,000 patient days to 16.64 infections per 10,000 discharges and incidence rates increased over time from 1997 to 2011. Rates were slightly higher for ESBL-Klebsiella infections than for ESBL-E. coli infections.

CONCLUSION

The incidence of ESBL-E. coli and ESBL-Klebsiella infections in the United States has increased, with slightly higher rates of ESBL-Klebsiella infections. Appropriate estimates of ESBL infections when coupled with other mechanisms of resistance will allow for the appropriate targeting of resources toward research, drug discovery, antimicrobial stewardship, and infection prevention.

Infect Control Hosp Epidemiol 2017;38:1209–1215

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 38 , Issue 10 , October 2017 , pp. 1209 - 1215
Copyright
© 2017 by The Society for Healthcare Epidemiology of America. All rights reserved 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

a

(Present affiliation: Ruth Lilly Medical Library, Indiana University School of Medicine, Indianapolis, Indiana [A.E.B.].).

PREVIOUS PRESENTATION: These data were presented in part at the Society for Healthcare Epidemiology of America 2015 Spring Conference in Orlando, Florida, on May 15, 2015.

References

REFERENCES

1. Jacoby, GA, Medeiros, AA, O’Brien, TF, Pinto, ME, Jiang, H. Broad-spectrum, transmissible beta-lactamases. N Engl J Med 1988;319:723–724.Google Scholar
2. Quinn, JP, Miyashiro, D, Sahm, D, Flamm, R, Bush, K. Novel plasmid-mediated beta-lactamase (TEM-10) conferring selective resistance to ceftazidime and aztreonam in clinical isolates of Klebsiella pneumoniae. Antimicrob Agents Chemother 1989;33:1451–1456.Google Scholar
3. Bush, K. Extended-spectrum beta-lactamases in North America, 1987–2006. Clinical Microbiology Infection 2008;14(Suppl 1):134–143.6.Google Scholar
4. Sader, HS, Jones, RN, Gales, AC, et al. Antimicrobial susceptibility patterns for pathogens isolated from patients in Latin American medical centers with a diagnosis of pneumonia: analysis of results from the SENTRY Antimicrobial Surveillance Program (1997). SENTRY Latin America Study Group. Diagn Microbiol Infect Dis. 1998(32):289–301.Google Scholar
5. Shen, D, Biedenbach, DJ, Winokur, PL, Pfaller, MA, Jones, RN. Phenotypic and genotypic characterizations of Chinese strains of Escherichia coli producing extended-spectrum beta-lactamases. Diagn Microbiol Infect Dis 1999;34:159–164.Google Scholar
6. Johnson, DM, Biedenbach, DJ, Jones, RN. In vitro evaluation of broad-spectrum beta-lactams in the Philippines medical centers: role of fourth-generation cephalosporins. The Philippines Antimicrobial Resistance Study Group. Diagn Microbiol Infect Dis 1999;35:291–297.Google Scholar
7. Gales, AC, Bolmstrom, A, Sampaio, J, Jones, RN, Sader, HS. Antimicrobial susceptibility of Klebsiella pneumoniae producing extended-spectrum beta-lactamase (ESBL) isolated in hospitals in Brazil. Braz J Infect Dis 1997;1:196–203.Google ScholarPubMed
8. Bell, JM, Turnidge, JD, Gales, AC, Pfaller, MA, Jones, RN, Sentry APAC Study Group. Prevalence of extended spectrum beta-lactamase (ESBL)-producing clinical isolates in the Asia-Pacific region and South Africa: regional results from SENTRY Antimicrobial Surveillance Program (1998–99). Diagn Microbiol Infect Dis 2002;42:193–198.Google Scholar
9. Einhorn, AE, Neuhauser, MM, Bearden, DT, Quinn, JP, Pendland, SL. Extended-spectrum beta-lactamases: frequency, risk factors, and outcomes. Pharmacotherapy 2002;22:14–20.CrossRefGoogle ScholarPubMed
10. Rice, LB. Successful interventions for gram-negative resistance to extended-spectrum beta-lactam antiobiotics. Pharmacotherapy 1999;19:120S–128S; discussion 133S–137S.Google Scholar
11. Pitout, JDD. Enterobacteriaceae that produce extended-spectrum β-lactamases and AmpC β-lactamases in the community: the tip of the iceberg? Cur Pharm Des 2013;19:257–263.Google Scholar
12. Jones, RN, Biedenbach, DJ, Gales, AC. Sustained activity and spectrum of selected extended-spectrum β-lactams (carbapenems and cefepime) against Enterobacter spp. and ESBL-producing Klebsiella spp.: report from the SENTRY antimicrobial surveillance program (USA, 1997–2000). Int J Antimicrob Agents 2003;21:1–7.Google Scholar
13. Castanheira, M, Mills, JC, Costello, SE, Jones, RN, Sader, HS. Ceftazidime-avibactam activity tested against Enterobacteriaceae isolates from US hospitals (2011 to 2013) and characterization of β-lactamase-producing strains. Antimicrob Agents Chemother 2015;59:3509–3517.Google Scholar
14. Winokur, PL, Canton, R, Casellas, JM, Legakis, N. Variations in the prevalence of strains expressing an extended-spectrum β-lactamase phenotype and characterization of isolates from Europe, the Americas, and the Western Pacific Region. Clin Infect Dis 2001;32:S94–S103.Google Scholar
15. Karlowsky, JA, Jones, ME, Mayfield, DC, Thornsberry, C, Sahm, DF. Ceftriaxone activity against gram-positive and gram-negative pathogens isolated in US clincial microbiology laboratories from 1996 to 2000: results from The Surveillance Network Database-USA. Int J Antimicrob Agents 2002;19:413–426.Google Scholar
16. Stang, A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol 2010;25:603–605.Google Scholar
17. Freeman, JT, Sexton, DJ, Anderson, DJ. Emergence of extended-spectrum beta-lactamase-producing Escherichia coli in community hospitals throughout North Carolina: a harbinger of a wider problem in the United States? Clin Infect Dis 2009;49:e30–e32.Google Scholar
18. Han, JH, Bilker, WB, Nachamkin, I, et al. The effect of a hospital-wide urine culture screening intervention on the incidence of extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella species. Infect Control Hosp Epidemiol 2013;34:1160–1166.Google Scholar
19. Hidron, AI, Edwards, JR, Patel, J, et al. NHSN annual update: antimicrobial-resistant pathogens associated with healthcare-associated infections: annual summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006–2007. Infect Control Hosp Epidemiol 2008;29:996–1011.CrossRefGoogle Scholar
20. Landman, D, Bratu, S, Kochar, S, et al. Evolution of antimicrobial resistance among Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae in Brooklyn, NY. J Antimicrob Chemother 2007;60:78–82.Google Scholar
21. Larson, EL, Cimiotti, JP, Haas, J, et al. Gram-negative bacilli associated with catheter-associated and non–catheter-associated bloodstream infections and hand carriage by healthcare workers in neonatal intensive care units. Pediatr Crit Care Med 2005;6:457–461.Google Scholar
22. Lipworth, AD, Hyle, EP, Fishman, NO, et al. Limiting the emergence of extended-spectrum beta-lactamase-producing enterobacteriaceae: influence of patient population characteristics on the response to antimicrobial formulary interventions. Infect Control Hosp Epidemiol 2006;27:279–286.Google Scholar
23. Soe, MM, Edwards, JR, Sievert, DM, Ricks, PM, Magill, SS, Fridkin, SK. Evaluting state-specific antibiotic resitance mesure derived from central line-associated bloodstream infetions, National Healthcare Safety Network, 2011. Infect Control Hosp Epidemiol 2015;36:54–64.Google Scholar
24. Stoll, BJ, Hansen, NI, Higgins, RD, et al. Very low birth weight preterm infants with early onset neonatal sepsis: the predominance of gram-negative infections continues in the National Institute of Child Health and Human Development Neonatal Research Network, 2002–2003. Pediatr Infect Dis J 2005;24:635–639.CrossRefGoogle Scholar
25. Swami, SK, Liesinger, JT, Shah, N, Baddour, LM, Banerjee, R. Incidence of antibiotic-resistant Escherichia coli bacteriuria according to age and location of onset: a population-based study from Olmsted County, Minnesota. Mayo Clinic Proc 2012;87:753–759.Google Scholar
26. Castanheira, M, Farrell, SE, Krause, KM, Jones, RN, Sader, HS. Contemporary diversity of β-lactamases among Enterobacteriaceae in the nine US regions and ceftrazidime-avibactam activiety tested against isolates producing the most prevalent β-lactamase groups. Antimicrob Agents Chemother 2014;58:833–838.Google Scholar
27. Karanika, S, Karantanos, T, Arvanitis, M, Grigoras, C, Mylonakis, E. Fecal colonization with extended-spectrum beta-lactamase-producing Enterobacteriaceae and risk factors among healthy individuals: a systematic review and meta-analysis. Clin Infect Dis 2016;63:310–318.Google Scholar
Supplementary material: File

McDanel supplementary material

Appendix

Download McDanel supplementary material(File)
File 43.3 KB