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Impact of Vancomycin Minimum Inhibitory Concentration on Mortality among Critically Ill Patients witn Methicillin-Resistant Staphylococcus aureus Bacteremia

Published online by Cambridge University Press:  02 January 2015

Christian J. Woods
Affiliation:
Pulmonary and Critical Care Medicine Section, Washington Hospital Center, Washington, DC Georgetown University, Washington, DC
Anindita Chowdhury
Affiliation:
Pulmonary and Critical Care Medicine Section, Washington Hospital Center, Washington, DC
Vinay M. Patel
Affiliation:
Pulmonary and Critical Care Medicine Section, Washington Hospital Center, Washington, DC
Andrew F. Shorr*
Affiliation:
Pulmonary and Critical Care Medicine Section, Washington Hospital Center, Washington, DC
*
Pulmonary and Critical Care Medicine, Room 2A-69D, Washington Hospital Center, 110 Irving Street NW, Washington, DC 20010 ([email protected])

Abstract

We retrospectively evaluated 99 intensive care unit patients with methicillin-resistant Staphylococcus aureus bacteremia to determine whether having a vancomycin minimum inhibitory concentration (MIC) of 2 mg/L affected mortality. This MIC was found in 5.1% of patients and was associated with the probability of death (adjusted odds ratio, 13.9 [95% confidence interval, 1.1–171.2]) independent of other factors.

Type
Concise Communication
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2012

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References

1.Sakoulas, G, Moellering, RC JrIncreasing antibiotic resistance among methicillin-resistant Staphylococcus aureus strains. Clin Infect Dis 2008;46:S360S367.10.1086/533592Google Scholar
2.Rybak, MJ, Leonard, SN, Rossi, KL, et al.Characterization of vancomycin-heteroresistant Staphylococcus aureus from the metropolitan area of Detroit, Michigan, over a 22-year period (1986 to 2007). J Clin Microbiol 2008;46:29502954.10.1128/JCM.00582-08Google Scholar
3.Lodise, TP, Graves, J, Evans, A, et al.Relationship between vancomycin MIC and failure among patients with methicillin-resistant Staphylococcus aureus bacteremia treated with vancomycin. Antimicrob Agents Chemother 2008;52:33153320.Google Scholar
4.Moise, PA, Sakoulas, G, Forrest, A, et al.Vancomycin in vitro bactericidal activity and its relationship to efficacy in clearance of methicillin-resistant Staphylococcus aureus bacteremia. Antimicrob Agents Chemother 2007;51:25822586.10.1128/AAC.00939-06Google Scholar
5.Hawkins, C, Huang, J, Jin, N, et al.Persistent Staphylococcus aureus bacteremia: an analysis of risk factors and outcomes. Arch Intern Med 2007;167:18611867.10.1001/archinte.167.17.1861Google Scholar
6.Musta, AC, Riederer, K, Shemes, S, et al.Vancomycin MIC plus heteroresistance and outcome of methicillin-resistant Staphylococcus aureus bacteremia: trends over 11 years. J Clin Microbiol 2009;47:16401644.10.1128/JCM.02135-08Google Scholar
7.Price, J, Atkinson, S, Llewelyn, M, et al.Paradoxical relationship between the clinical outcome of Staphylococcus aureus bacteremia and the minimum inhibitory concentration of vancomycin. Clin Infect Dis 2009;48:997998.10.1086/597359Google Scholar
8.Sader, HS, Fey, PD, Limaye, AP, et al.Evaluation of vancomycin and daptomycin potency trends (MIC creep) against methicillin-resistant Staphylococcus aureus isolates collected in nine U.S. medical centers from 2002 to 2006. Antimicrob Agents Chemother 2009;53:41274132.10.1128/AAC.00616-09Google Scholar
9.Soriano, A, Marco, F, Martinez, JA, et al.Influence of vancomycin minimum inhibitory concentration on the treatment of methicillin-resistant Staphylococcus aureus bacteremia. Clin Infect Dis 2008;46:193200.10.1086/524667Google Scholar
10.van Hall, SJ, Lodise, TP, Paterson, DL. The clinical significance of vancomycin minimum inhibitory concentration in Staphylococcus aureus infections: a systematic review and meta-analysis. Clin Infect Dis (in press).Google Scholar