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The Impact of Ertapenem Use on the Susceptibility of Pseudomonas aeruginosa to Imipenem A Hospital Case Study

Published online by Cambridge University Press:  02 January 2015

Ana Lucia L. Lima ,
Priscila R. Oliveira ,
Adriana P. Paula ,
Karine Dal-Paz ,
Flavia Rossi  and
Arnaldo V. Zumiotti
Ana Lucia L. Lima*
Affiliation:
Institute of Orthopedics and Traumatology, Hospital das Clínicas, University of São Paulo School of Medicine, São Paulo, Brazil
Priscila R. Oliveira
Affiliation:
Institute of Orthopedics and Traumatology, Hospital das Clínicas, University of São Paulo School of Medicine, São Paulo, Brazil
Adriana P. Paula
Affiliation:
Institute of Orthopedics and Traumatology, Hospital das Clínicas, University of São Paulo School of Medicine, São Paulo, Brazil
Karine Dal-Paz
Affiliation:
Institute of Orthopedics and Traumatology, Hospital das Clínicas, University of São Paulo School of Medicine, São Paulo, Brazil
Flavia Rossi
Affiliation:
Microbiology Laboratory, Hospital das Clínicas, University of São Paulo School of Medicine, São Paulo, Brazil
Arnaldo V. Zumiotti
Affiliation:
Institute of Orthopedics and Traumatology, Hospital das Clínicas, University of São Paulo School of Medicine, São Paulo, Brazil
*
Alameda Gabriel Monteiro da Silva, 429, São Paulo, Brazil01414-000) [email protected])
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Abstract

We sought to evaluate the indirect impact of ertapenem use for the treatment of extended-spectrum β-lactamase-producing Enterobacteriaceae infections in our hospital on the susceptibility of Pseudomonas aeruginosa to imipenem. The use of ertapenem was mandated for treatment of extended-spectrum β-lactamase-producing Enterobacteriaceae infections in the absence of nonfermenting gram-negative bacilli for 1 year. The use of imipenem was restricted. Imipenem consumption decreased 64.5%. Ertapenem consumption was 42.57 defined daily doses per 1,000 patient-days. None of the 18 P. aeruginosa isolates recovered after ertapenem introduction were imipenem-resistant, compared with 4 of the 20 P. aeruginosa isolates recovered in the previous year.

Type
Concise Communications
Information
Infection Control & Hospital Epidemiology , Volume 30 , Issue 5 , May 2009 , pp. 487 - 490
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2009

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