Hostname: page-component-586b7cd67f-r5fsc Total loading time: 0 Render date: 2024-11-24T22:35:43.131Z Has data issue: false hasContentIssue false

Impact of antibiotic heterogeneity by periodic antibiotic monitoring and supervision strategy at two units with different prevalences of multidrug-resistant organisms

Published online by Cambridge University Press:  09 June 2021

Surachai Chaononghin
Affiliation:
Division of Infectious Diseases, Faculty of Medicine, Thammasat University, Prathum Thani, Thailand
Kittiya Jantarathaneewat
Affiliation:
Department of Pharmaceutical Care, Faculty of Pharmacy, Thammasat University, Prathum Thani, Thailand
David J. Weber
Affiliation:
University of North Carolina, Gillings School of Global Public Health, Chapel Hill, North Carolina, United States
David K. Warren
Affiliation:
Division of Infectious Diseases, Washington University School of Medicine, St Louis, Missouri, United States
Anucha Apisarnthanarak*
Affiliation:
Division of Infectious Diseases, Faculty of Medicine, Thammasat University, Prathum Thani, Thailand
*
Author for correspondence: Anucha Apisarnthanarak, E-mail: [email protected]

Abstract

In an intensive care unit, antibiotic heterogeneity led to an increase in antibiotic heterogeneity index (P = .002) and a reduction in carbapenem-resistance Enterobacteriaceae incidence (P = .04). In a general medicine unit with low prevalence of multidrug-resistant organisms, antibiotic heterogeneity index and incidence of multidrug-resistant organisms did not improve.

Type
Concise Communication
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Kollef, MH, Fraser, VJ. Antibiotic resistance in the intensive care unit setting. Ann Intern Med 2001;134:298314.CrossRefGoogle Scholar
Apisarnthanarak, A, Kwa, AL, Chiu, C, et al. Antimicrobial stewardship for acute-care hospitals: an Asian perspective. Infect Control Hosp Epidemiol 2018;39:12371245.Google Scholar
Takesue, Y, Nakajima, K, Ichiki, K, et al. Impact of a hospital-wide programme of heterogeneous antibiotic use on the development of antibiotic-resistant gram-negative bacteria. J Hosp Infect 2010;75:2832.CrossRefGoogle ScholarPubMed
Takesue, Y, Ohge, H, Sakashita, M, et al. Effect of antibiotic heterogeneity on the development of infections with antibiotic-resistant gram-negative organisms in a non–intensive care unit surgical ward. World J Surg 2006;30:12691276.CrossRefGoogle Scholar
Apisarnthanarak, A, Kiratisin, P, Saifon, P, et al. Clinical and molecular epidemiology of community-onset, extended-spectrum β-lactamase–producing Escherichia coli infections in Thailand: a case–case-control study. Am J Infect Control 2007;35:606612.CrossRefGoogle ScholarPubMed
Warren, DK, Hill, HA, Merz, LR, et al. Cycling empirical antimicrobial agents to prevent emergence of antimicrobial-resistant gram-negative bacteremia among intensive care unit patients. Crit Care Med 2004;32:24502456.Google Scholar
Ng, TM, Teng, CB, Lye, DC, et al. A multicenter case–case-control study for risk factors and outcomes of extensively drug-resistant Acinetobacter baumannii bacteremia. Infect Control Hosp Epidemiol 2014;35:4955.CrossRefGoogle ScholarPubMed
Supplementary material: File

Chaononghin et al. supplementary material

Chaononghin et al. supplementary material

Download Chaononghin et al. supplementary material(File)
File 31.9 KB