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Host-Bacteria Interactions in Foreign Body Infections

Published online by Cambridge University Press:  02 January 2015

Patrice François ,
Pierre Vaudaux ,
Timothy J. Foster  and
Daniel P. Lew
Patrice François
Affiliation:
Division of Infectious Diseases, University Hospital, Geneva, Switzerland
Pierre Vaudaux*
Affiliation:
Division of Infectious Diseases, University Hospital, Geneva, Switzerland
Timothy J. Foster
Affiliation:
Microbiology Department, Moyne Institute, Trinity College, Dublin, Ireland
Daniel P. Lew
Affiliation:
Division of Infectious Diseases, University Hospital, Geneva, Switzerland
*
Division of Infectious Diseases, University Hospital, CH-1211 Geneva 14, Switzerland
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Abstract

Persistent staphylococcal infections are a major medical problem, especially when they occur on implanted materials or intravascular catheters. This review describes some of the recently discovered molecular mechanisms of Staphylococcus aureus attachment to host proteins coating biomedical implants. These interactions involve specific surface proteins, called bacterial adhesins, that recognize specific domains of host proteins deposited on indwelling devices, such as fibronectin, fibrinogen, or fibrin. Elucidation of molecular mechanisms of S aureus adhesion to the different host proteins may lead to the development of specific inhibitors blocking attachment of S aureus, which may decrease the risk of bacterial colonization of indwelling devices.

Type
From the Fourth International Conference on the Prevention of Infection
Information
Infection Control & Hospital Epidemiology , Volume 17 , Issue 8 , August 1996 , pp. 514 - 520
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1996

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