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Health Implications of Antimicrobial Resistance for Patients With Acute Kidney Injury and Bloodstream Infection

Published online by Cambridge University Press:  02 January 2015

Eric A. J. Hoste ,
Dominique M. Vandijck ,
Raymond C. Vanholder ,
Jan J. De Waele ,
Norbert H. Lameire ,
Stefaan Claus ,
Johan De Schuijmer ,
Annemieke W. Dhondt ,
Johan M. A. Decruyenaere  and
Gerda Verschraegen
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Eric A. J. Hoste*
Affiliation:
Department of Intensive Care, Ghent University Hospital, Ghent, Belgium
Dominique M. Vandijck
Affiliation:
Department of Intensive Care, Ghent University Hospital, Ghent, Belgium
Raymond C. Vanholder
Affiliation:
Renal Division, Ghent University Hospital, Ghent, Belgium
Jan J. De Waele
Affiliation:
Department of Intensive Care, Ghent University Hospital, Ghent, Belgium
Norbert H. Lameire
Affiliation:
Renal Division, Ghent University Hospital, Ghent, Belgium
Stefaan Claus
Affiliation:
Renal Division, Ghent University Hospital, Ghent, Belgium
Johan De Schuijmer
Affiliation:
Hospital Infection Control Department, Ghent University Hospital, Ghent, Belgium
Annemieke W. Dhondt
Affiliation:
Renal Division, Ghent University Hospital, Ghent, Belgium
Johan M. A. Decruyenaere
Affiliation:
Department of Intensive Care, Ghent University Hospital, Ghent, Belgium
Gerda Verschraegen
Affiliation:
Hospital Infection Control Department, Ghent University Hospital, Ghent, Belgium
Stijn I. Blot
Affiliation:
Department of Intensive Care, Ghent University Hospital, Ghent, Belgium
*
Intensive Care Department, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium ([email protected])
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Abstract

Studies have produced conflicting findings on outcomes for patients with antimicrobial-resistant infection. This study evaluated whether infection with an antimicrobial-resistant organism affects outcome in critically ill patients with acute kidney injury treated with renal replacement therapy and whose clinical course is complicated with a nosocomial bloodstream infection. We found that infection with an antimicrobial-resistant organism did not adversely affect clinical outcome in this specific cohort, which already has a high mortality rate.

Type
Concise Communications
Information
Infection Control & Hospital Epidemiology , Volume 28 , Issue 9 , September 2007 , pp. 1107 - 1110
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2007

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References

1. Cosgrove, SE, Kaye, KS, Eliopoulous, GM, Carmeli, Y. Health and economic outcomes of the emergence of third-generation cephalosporin resistance in Enterobacter species. Arch Intern Med 2002;162:185–190.CrossRefGoogle ScholarPubMed
2. Niederman, MS. Impact of antibiotic resistance on clinical outcomes and the cost of care. Crit Care Med 2001;29:N114–N120.Google Scholar
3. Blot, SI, Vandewoude, KH, Hoste, EA, Colardyn, FA. Outcome and attributable mortality in critically ill patients with bacteremia involving methicillin-susceptible and methicillin-resistant Staphylococcus aureus . Arch Intern Med 2002;162:2229–2235.Google Scholar
4. Hoste, EA, Lameire, NH, Vanholder, RC, Benoit, DD, Decruyenaere, JM, Colardyn, FA. Acute renal failure in patients with sepsis in a surgical ICU: predictive factors, incidence, comorbidity, and outcome. J Am Soc Nephrol 2003;14:1022–1030.Google Scholar
5. Hoste, EA, Blot, SI, Lameire, NH, Vanholder, RC, De Bacquer, D, Colardyn, FA. Effect of nosocomial bloodstream infection on the outcome of critically ill patients with acute renal failure treated with renal replacement therapy. J Am Soc Nephrol 2004;15:454–462.Google Scholar
6. Garner, JS, Jarvis, WR, Emori, TG, Horan, TC, Hughes, JM. CDC definitions for nosocomial infections, 1988. Am J Infect Control 1988;16:128–140.CrossRefGoogle ScholarPubMed
7. Vandijck, DM, Decruyenaere, JM, Blot, SI. The value of sepsis definitions in daily ICU-practice. Acta Clin Belg 2006;61:220–226.Google Scholar
8. Blot, S, Vandewoude, K, Hoste, E, et al. Absence of excess mortality in critically ill patients with nosocomial Escherichia coli bacteremia. Infect Control Hosp Epidemiol 2003;24:912–915.Google Scholar
9. Blot, SI, Depuydt, P, Annemans, L, et al. Clinical and economic outcomes in critically ill patients with nosocomial catheter-related bloodstream infections. Clin Infect Dis 2005;41:1591–1598.Google Scholar
10. Kim, PW, Perl, TM, Keelaghan, EF, et al. Risk of mortality with a bloodstream infection is higher in the less severely ill at admission. Am J Respir Crit Care Med 2005;171:616–620.CrossRefGoogle ScholarPubMed
11. Himmelfarb, J, McMonagle, E, Freedman, S, et al. Oxidative stress is increased in critically ill patients with acute renal failure. J Am Soc Nephrol 2004;15:2449–2456.CrossRefGoogle ScholarPubMed