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Epidemiology of Staphylococcus Aureus Infections in Patients on Hemodialysis

Published online by Cambridge University Press:  02 January 2015

J. Ena ,
J.R. Boelaert ,
L.D. Boyken ,
H.W. Van Landuyt ,
C.A. Godard  and
LA. Herwaldt
J. Ena
Affiliation:
Division of General Medicine, Clinical Epidemiology and Health Services Research, Department of Internal Medicine C41, GH, University of Iowa, Iowa City, Iowa
J.R. Boelaert
Affiliation:
Unit of Renal and Infectious Disease, and Department of Microbiology, Algemeen Ziekenhuis St. Jan, Brugge, Belgium
L.D. Boyken
Affiliation:
Division of General Medicine, Clinical Epidemiology and Health Services Research, Department of Internal Medicine C41, GH, University of Iowa, Iowa City, Iowa Veterans Administration Medical Center, Iowa City, Iowa
H.W. Van Landuyt
Affiliation:
Unit of Renal and Infectious Disease, and Department of Microbiology, Algemeen Ziekenhuis St. Jan, Brugge, Belgium
C.A. Godard
Affiliation:
Institut Pasteur du Brabant, Bruxelles, Belgium
LA. Herwaldt*
Affiliation:
Division of General Medicine, Clinical Epidemiology and Health Services Research, Department of Internal Medicine C41, GH, University of Iowa, Iowa City, Iowa Veterans Administration Medical Center, Iowa City, Iowa
*
Department of Internal Medicine, University of Iowa Hospitals and Clinics, 200 Hawkins Dr, Iowa City, IA 52242-1081
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Abstract

Objective:

To determine the epidemiology of Staphylococcus aureus infections in hemodialysis patients.

Method:

S aureus isolates from surveillance cultures and from sites of infection were evaluated by both bacteriophage typing and restriction endonuclease digestion of plasmid DNA.

Setting:

A hemodialysis unit in Brugge, Belgium.

Organisms:

S aureus isolates from 11 chronic hemodialysis patients who had participated in the placebo arm of a previously reported placebo-mupirocin comparative study.

Results:

Of 75 S aureus isolates evaluated, 63 were from cultures of nares and 12 from infections (three arteriovenous fistula infections, four wound infections, and five bacteremias). All isolates were typed by bacteriophages and 56 (75%) had plasmids. Three patients developed 12 infections. Eleven infections were caused by isolates previously identified in surveillance cultures. Only one infection was caused by a strain not identified previously in surveillance cultures.

Conclusion:

These results support the hypothesis that S aureus isolates causing infections in hemodialysis patients are of endogenous origin.

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 15 , Issue 2 , February 1994 , pp. 78 - 81
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1994

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