Hostname: page-component-78c5997874-mlc7c Total loading time: 0 Render date: 2024-11-02T19:02:10.808Z Has data issue: false hasContentIssue false
  • English
  • Français

Efficacy of Combination of N-acetylcysteine, Gentamicin, and Amphotericin B for Prevention of Microbial Colonization of Ventricular Assist Devices

Published online by Cambridge University Press:  02 January 2015

Maria D. Hernandez ,
Mohammad D. Mansouri ,
Saima Aslam ,
Barry Zeluff  and
Rabih O. Darouiche
Maria D. Hernandez
Affiliation:
Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas
Mohammad D. Mansouri
Affiliation:
Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas Center for Prostheses Infection, Baylor College of Medicine, Houston, Texas
Saima Aslam
Affiliation:
Michael E. DeBakey Veterans Affairs Medical Center, Baylor College of Medicine, Houston, Texas St. Luke's Episcopal Hospital, Baylor College of Medicine, Houston, Texas Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas
Barry Zeluff
Affiliation:
St. Luke's Episcopal Hospital, Baylor College of Medicine, Houston, Texas
Rabih O. Darouiche*
Affiliation:
Michael E. DeBakey Veterans Affairs Medical Center, Baylor College of Medicine, Houston, Texas Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas Center for Prostheses Infection, Baylor College of Medicine, Houston, Texas
*
Center for Prostheses Infection, 1333 Moursund Avenue, Suite A221, Houston, TX 77030 ([email protected])
Get access Rights & Permissions [Opens in a new window]

Abstract

We assessed the in vitro antimicrobial activity and the in vivo efficacy of dipping ventricular assist devices in a combination of N-acetylcysteine, gentamicin, and amphotericin B (NAC/G/A). Ventricular assist devices dipped in NAC/G/A exhibited broad-spectrum antimicrobial activity in vitro and were less likely than undipped devices to become colonized with Staphylococcus aureus in a rabbit model.

Type
Concise Communications
Information
Infection Control & Hospital Epidemiology , Volume 30 , Issue 2 , February 2009 , pp. 190 - 192
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2009

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Gordon, RJ, Quagliarello, B, Lowy, FD. Ventricular assist device-related infections. Lancet Infect Dis 2006;6:426–437.CrossRefGoogle ScholarPubMed
2.Perez-Giraldo, C, Rodriguez-Benito, A, Moran, FJ, Hurtado, C, Blanco, MT, Gomez-Garcia, AC. Influence of N-acetylcysteine on the formation of biofilm by Staphylococcus epidermidis. J Antimicrob Chemother 1997;39:643–646.CrossRefGoogle ScholarPubMed
3.Mansouri, MD, Darouiche, RO. In vitro antimicrobial activity of N-acetylcysteine against bacteria colonising central venous catheters. Int J Antimicrob Agents 2007;29:474–476.CrossRefGoogle ScholarPubMed
4.Sherertz, RJ, Forman, DM, Solomon, DD. Efficacy of dicloxacillin-coated Polyurethane catheters in preventing subcutaneous Staphylococcus aureus infection in mice. Antimicrob Agents Chemother 1989;33:1174–1178.Google Scholar
5.Clinical and Laboratory Standards Institute (CLSI). Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically: approved standard. 7th ed. Wayne, PA: CLSI; 2006:M07–A7.Google Scholar
6.Yu, VL, Weber, R, Raoult, D, eds. Antimicrobial Therapy and Vaccines. 2nd ed. New York: Apple Trees Productions; 2003.Google Scholar
7.Darouiche, RO, Mansouri, MD. In vitro activity and in vivo efficacy of antimicrobial-coated vascular grafts. Ann Vase Surg 2004;18:497–501.Google Scholar
8.Sherertz, RJ, Carruth, WA, Hampton, AA, Byron, MP, Solomon, DD. Efficacy of antibiotic-coated catheters in preventing subcutaneous Staphylococcus aureus infection in rabbits. J Infect Dis 1993;167:98–106.CrossRefGoogle ScholarPubMed
9.Raad, I, Darouiche, R, Dupuis, J, et al., Texas Medical Center Catheter Study Group. Central venous catheters coated with minocycline and rifampin for the prevention of catheter-related colonization and bloodstream infections: a randomized, double-blind trial. Ann Intern Med 1997;127:267–274.Google Scholar
10.Aslam, S, Trautner, BW, Ramanathan, V, Darouiche, RO. Combination of tigecycline and N-acetylcysteine reduces biofilm-embedded bacteria on vascular catheters. Antimicrob Agents Chemother 2007;51:1556–1558.Google Scholar