Hostname: page-component-586b7cd67f-r5fsc Total loading time: 0 Render date: 2024-11-30T20:10:50.405Z Has data issue: false hasContentIssue false
  • English
  • Français

Efficacy of Adding 2% (w/v) Chlorhexidine Gluconate to 70% (v/v) Isopropyl Alcohol for Skin Disinfection Prior to Peripheral Venous Cannulation

Published online by Cambridge University Press:  02 January 2015

Heather Small ,
Debra Adams ,
Anna L. Casey ,
Cynthia T. Crosby ,
Peter A. Lambert  and
Thomas Elliott
Heather Small
Affiliation:
Department of Clinical Microbiology and Infection Control, University Hospital Birmingham NHS Foundation Trust, The Queen Elizabeth Hospital, Edgbaston, Birmingham, England
Debra Adams
Affiliation:
Department of Clinical Microbiology and Infection Control, University Hospital Birmingham NHS Foundation Trust, The Queen Elizabeth Hospital, Edgbaston, Birmingham, England
Anna L. Casey
Affiliation:
Department of Clinical Microbiology and Infection Control, University Hospital Birmingham NHS Foundation Trust, The Queen Elizabeth Hospital, Edgbaston, Birmingham, England
Cynthia T. Crosby
Affiliation:
Enturia, Leawood, Kansas
Peter A. Lambert
Affiliation:
Department of Pharmaceutical and Biological Sciences, Aston University, Aston Triangle, Birmingham, England
Thomas Elliott*
Affiliation:
Department of Clinical Microbiology and Infection Control, University Hospital Birmingham NHS Foundation Trust, The Queen Elizabeth Hospital, Edgbaston, Birmingham, England
*
Selly Oak Hospital, Raddlebarn Rd., Selly Oak, Birmingham, B29 6JD, England ([email protected])
Get access Rights & Permissions [Opens in a new window]

Abstract

We undertook a clinical trial to compare the efficacy of 2% (w/v) chlorhexidine gluconate in 70% (v/v) isopropyl alcohol with the efficacy of 70% (v/v) isopropyl alcohol alone for skin disinfection to prevent peripheral venous catheter colonization and contamination. We found that the addition of 2% chlorhexidine gluconate reduced the number of peripheral venous catheters that were colonized or contaminated.

Type
Concise Communication
Information
Infection Control & Hospital Epidemiology , Volume 29 , Issue 10 , October 2008 , pp. 963 - 965
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2008

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Maki, DG, Crinch, CJ. Line sepsis in the ICU: prevention, diagnosis, and management. Semin Respir Crit Care Med 2003;24:23–36.CrossRefGoogle ScholarPubMed
2.O'Grady, NP, Alexander, M, Dellinger, EP, et al.Guidelines for the prevention of intravascular catheter-related infections. MMWR Recomm Rep 2002;51:4–8.Google ScholarPubMed
3.Moss, HA, Elliott, TSJ, Tebbs, SE, et al.Novel approach to investigate a source of microbial contamination of central venous catheters. Eur J Clin Microbiol Infect Dis 1997;16:210–213.Google Scholar
4.Maki, DG, Ringer, M, Alvarado, CJ. Prospective randomised trial of pov-idone-iodine, alcohol, and chlorhexidine for prevention of infection associated with central venous and arterial catheters. Lancet 1991;338:339–343.Google Scholar
5.Hibbard, JS, Mulberry, GK, Brady, AR. A clinical study comparing the skin antisepsis and safety of ChloraPrep, 70% isopropyl alcohol, and 2% aqueous chlorhexidine. J Infus Nurs 2002;25:244–249.CrossRefGoogle ScholarPubMed
6.Ostrander, RV, Botte, MJ, Brage, ME. Efficacy of surgical preparation solutions in foot and ankle surgery. J Bone Joint Surg Am 2005;87:980–985.Google Scholar
7.Adams, D, Quayum, M, Worthington, T, Lambert, P, Elliott, T. Evaluation of a 2% chlorhexidine gluconate in 70% isopropyl alcohol skin disinfectant. J Hosp Infect 2005;61:287–290.CrossRefGoogle ScholarPubMed
8.Pratt, RJ, Pellowe, CM, Wilson, JA, et al.Epic 2: national evidence-based guidelines for preventing healthcare associated infections in NHS hospitals in Englands. J Hosp Infect 2007;65(Suppl 1):S1–S64.Google Scholar
9.Brun-Buisson, C, Abrouk, F, Legrand, P, Huet, Y, Larabi, S, Rapin, M. Diagnosis of central venous catheter-related sepsis, critical level of quantitative tip cultures. Arch Intern Med 1987;147:873–877.Google Scholar
10.Carret, L, Reverdy, ME, Lafforgue, C, Falson, F, Fleurette, J, Freney, J. Kinetics of chlorhexidine on intact skin following a single application. Pathol Biol (Paris) 1997;45:737–740.Google ScholarPubMed