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Effect of testing methods on incidence of Clostridioides difficile infection rates in Veterans’ Affairs medical centers

Published online by Cambridge University Press:  13 November 2020

Brian P. McCauley Open the ORCID record for Brian P. McCauley [Opens in a new window] ,
Martin E. Evans ,
Loretta A. Simbartl ,
Shantini D. Gamage ,
Stephen M. Kralovic  and
Gary A. Roselle
Brian P. McCauley*
Affiliation:
National Infectious Diseases Service, Specialty Care Services, Veterans’ Affairs Central Office, Washington, DC MRSA/MDRO Prevention Office, National Infectious Diseases Service, Specialty Care Services, Veterans’ Affairs Central Office, Washington, DC
Martin E. Evans
Affiliation:
MRSA/MDRO Prevention Office, National Infectious Diseases Service, Specialty Care Services, Veterans’ Affairs Central Office, Washington, DC Lexington Veterans’ Affairs Medical Center, Lexington, Kentucky Division of Infectious Diseases, Department of Internal Medicine, University of Kentucky School of Medicine, Lexington, Kentucky
Loretta A. Simbartl
Affiliation:
National Infectious Diseases Service, Specialty Care Services, Veterans’ Affairs Central Office, Washington, DC
Shantini D. Gamage
Affiliation:
National Infectious Diseases Service, Specialty Care Services, Veterans’ Affairs Central Office, Washington, DC Division of Infectious Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio
Stephen M. Kralovic
Affiliation:
National Infectious Diseases Service, Specialty Care Services, Veterans’ Affairs Central Office, Washington, DC Division of Infectious Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio Cincinnati Veterans’ Affairs Medical Center, Cincinnati, Ohio
Gary A. Roselle
Affiliation:
National Infectious Diseases Service, Specialty Care Services, Veterans’ Affairs Central Office, Washington, DC Division of Infectious Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio Cincinnati Veterans’ Affairs Medical Center, Cincinnati, Ohio
*
Author for correspondence: Brian P. McCauley, E-mail: [email protected]
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Abstract

Clostridioidesdifficile infection rates from 7 facilities that used nucleic acid amplification testing (NAAT) alone for 12 months then switched to NAAT plus toxin enzyme immunoassay (EIA) and reported the latter result for 12 months were compared to 70 facilities that used NAAT alone for all 24 months. There was no significant difference in rates between facility groups over the first 12 months (P = .21, linear regression), but we detected a decrease in rates for the facilities that changed to NAAT+EIA (P < .0001).

Type
Concise Communication
Information
Infection Control & Hospital Epidemiology , Volume 42 , Issue 4 , April 2021 , pp. 461 - 463
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Copyright
© 2020 by The Society for Healthcare Epidemiology of America. All rights reserved.

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References

Evans, EM, Kralovic, MS, et al. Effect of a Clostridium difficile infection prevention initiative in Veterans’ Affairs acute care facilities. Infect Control Hosp Epidemiol 2014;37:720–722.CrossRefGoogle Scholar
Cohen, HS, Gerding, ND, Johnson, S, et al. Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA). Infect Control Hosp Epidemiol 2010;31:431–455.CrossRefGoogle Scholar
Polage, RC, Gyorke, EC, Kennedy, AM et al. Overdiagnosis of Clostridium difficile infection in the molecular test era. JAMA Intern Med 2015;175:1792–1801.CrossRefGoogle ScholarPubMed
McDonald, CL HS, Gerding, ND, Johnson, S, et al. clinical practice guidelines for Clostridium difficile infection in adults and children: 2017 update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA). Clin Infect Dis 2018;66(7):e1–e48.CrossRefGoogle Scholar
The National Healthcare Safety Network (NHSN) manual: patient safety component. US Centers for Disease Control and Prevention website. https://www.cdc.gov/nhsn/PDFs/pscManual/12pscMDRO_CDADcurrent.pdf. Accessed September 12, 2020.Google Scholar
Veterans’ Health Administration Hospital Performance Data. Centers for Medicare & Medicaid Services website. https://www.cms.gov/Medicare/Quality-Initiatives-Patient-Assessment-Instruments/HospitalQualityInits/VA-Data. Updated October 2016. Accessed September 14, 2020.Google Scholar
Shultz, K, Sickbert-Bennett, E, Marx, A, et al. Preventable patient harm: a multidisciplinary, bundled approach to reducing Clostridium difficile infections while using a glutamate dehydrogenase/toxin immunochromatographic assay/nucleic acid amplification test diagnostic algorithm. J Clin Microbiol 2018;56(9):e00625-18.Google Scholar
Singh, BM, Evans, EM et al. Evaluating the effect of a Clostridium difficile infection prevention initiative in Veterans’ Health Administration long-term care facilities. Infect Control Hosp Epidemiol 2018;39:343–345.CrossRefGoogle Scholar
Humphries, MR, Uslan, ZD, Rubin, Z. Performance of Clostridium difficile toxin enzyme immunoassay and nucleic acid amplification tests stratified by patient disease severity. J Clin Microbiol 2013;02970-12:1–10.Google ScholarPubMed