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The economic burden of Clostridioides difficile infection in patients with hematological malignancies in the United States: A case-control study

Published online by Cambridge University Press:  15 May 2020

Lola Duhalde ,
Lise Lurienne ,
Sebastian M. Wingen-Heimann ,
Lucien Guillou ,
Renaud Buffet  and
Pierre-Alain Bandinelli
Lola Duhalde
Affiliation:
Da Volterra, Paris, France Ecole Polytechnique, Palaiseau, France
Lise Lurienne
Affiliation:
Da Volterra, Paris, France
Sebastian M. Wingen-Heimann
Affiliation:
Department of Internal Medicine, University Hospital of Cologne, Cologne, Germany FOM University of Applied Sciences, Cologne, Germany
Lucien Guillou
Affiliation:
Da Volterra, Paris, France Faculty of Pharmacy, University Paris-Sud, Châtenay-Malabry, France
Renaud Buffet
Affiliation:
Da Volterra, Paris, France
Pierre-Alain Bandinelli*
Affiliation:
Da Volterra, Paris, France
*
Author for correspondence: Pierre-Alain Bandinelli, E-mail: [email protected]
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Abstract

Objective:

The primary study aim was to describe all direct healthcare costs associated with Clostridioides difficile infection (CDI), both in and out of the hospital, in patients with hematologic malignancies in the United States.

Design:

A retrospective analysis was conducted utilizing data from US databases of Truven Health Analytics.

Patients:

We analyzed health insurance claims between January 2014 and December 2017 of patients diagnosed with hematological cancer: acute myeloid leukemia (AML), acute lymphoblastic leukemia, Hodgkin’s lymphoma, and non-Hodgkin’s lymphoma (NHL).

Methods:

Patients with CDI after cancer diagnosis (CDI+, cases) were matched with patients without CDI reported (CDI−, controls). Matched cases and controls were compared to identify the CDI-associated costs in the 90 days following the onset of CDI.

Results:

We matched 622 CDI+ patients with 11,111 CDI− patients. NHL (41.7%) and AML (30.9%) were the predominant underlying diseases in the CDI+ groups. During study period, the average time in-hospital of CDI+ patients was 23.1 days longer than for CDI− patients (P < 2×10−16). Overall, CDI onset increased costs of care by an average of US$57,159 per patient (P = 6×10−12), mainly driven by hospital costs.

Conclusions:

This study confirms the significant economic burden associated with CDI in the United States, especially in patients with hematological malignancies. These findings highlight the need for prevention of CDI in this specific patient population.

Type
Original Article
Information
Infection Control & Hospital Epidemiology , Volume 41 , Issue 7 , July 2020 , pp. 813 - 819
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Copyright
© 2020 by The Society for Healthcare Epidemiology of America. All rights reserved.

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