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Do Nonclinical Uses of Antibiotics Make a Difference?

Published online by Cambridge University Press:  02 January 2015

Hilary-Kay Young
Hilary-Kay Young*
Affiliation:
Department of Biological Sciences, University of Dundee, United Kingdom
*
Department of Biological Sciences, University of Dundee, Dundee DD1 4HN, United Kingdom
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Abstract

An increasing range of antibacterial compounds is being used for nonclinical purposes, especially in the fields of animal husbandry and fish farming. As in human medicine, exposure to antibiotics has lead to the emergence of antibiotic-resistant bacteria in animal populations. The potential impact of antibiotic use in animals on human health and the management of clinical infections in humans is discussed in light of growing evidence to suggest that “new” resistance genes and multiresistant pathogens with increased pathogenicity are emerging in food animals as a direct consequence of antibiotic exposure.

Type
From the Third International Conference on the Prevention of Infection
Information
Infection Control & Hospital Epidemiology , Volume 15 , Issue 7 , July 1994 , pp. 484 - 487
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1994

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References

1. Moellering, RC. Interaction between antimicrobial consumption and selection of resistant bacterial strains. Scand J Infect Dis 1990:70(suppl):18–24.Google ScholarPubMed
2. DuPont, HL, Steele, JH. Use of antimicrobial agents in animal feeds: implications for human health. Rev Inject Dis 1987;9:447–460.CrossRefGoogle ScholarPubMed
3. Yndestad, M. Public health aspects of residues in animal products: fundamental considerations. In: Chemotherapy in Aquaculture: Form Theory to Reality. Paris, France: Office Internationale Des Epizooties: 1992:494–511.Google Scholar
4. Leffertstra, H. Steps towards a sustainable fish farming industry, environmental goals and new regulations to achieve these for fish farming in Norway . In: De Pauw, N. Joyce, J, eds. Aquaculture and the Environment. European Aquaculture Society; 1991;16:461–466.Google Scholar
5. Swann, MM. Joint Committee on the Use of Antibiotics in Animal Husbandry and Veterinary Medicine. London, England: Her Majesty's Stationery Office; 1969.Google Scholar
6. Gellin, G, Langlois, BE, Dawson, KA, Aaron, D. Antibiotic resistance of gram-negative enteric bacteria from pigs in three herds with different histories of antibiotic exposure. Appl Environ Microbiol 1989;55:2287–2292.CrossRefGoogle ScholarPubMed
7. Walton, JR. Apramycin, a new aminocylitol antibiotic. J Antimicrob Chemother 1978;4:309–313.Google Scholar
8. Bowen, RE, Davies, J, Walton, JR, Bennett, TH. Apramycin, a new aminocylitol aminoglycoside antibiotic: microbiological safety. Proceedings of the Fourth International Pig Veterinary Society Congress. Ames, Iowa: International Pig Veterinary Society Congress;1976:B3.Google Scholar
9. Davies, J, O'Connor, S. Enzymatic modification of aminoglycoside antibiotics: 3-N-acetyl transferase with broad specificity that determines resistanceto the novel aminoglycoside apramycin. Antimicrob Agents Chemother 1978;14:6972.Google Scholar
10. Hedges, RW, Shannon, KP. Resistance to apramycin in Escherichia coli isolated from animals: detection of a novel aminoglycoside-modifying enzyme. J Gen Microbiol 1984;130:473–482.Google Scholar
11. Lovering, AM, White, LO, Reeves, DS. AAC(1): a new aminoglycoside-acetylating enzyme modifying the Cl aminogroup of apramycin. J Antimicrob Chemother 1987;20:803–813.Google Scholar
12. Hunter, JEB. Hart, CA, Shelley, JC, Walton, JR, Bennett, M. Human isolates of apramycin-resistant Escherichia coli which contain the genes for the AAC(3)IV enzyme. Epidemiol Infect 1993;110:253–259.Google Scholar
13. Salauze, D, Otal, I, Gomez-Lus, R, Davies, J. Aminoglycoside acetyltransferase 3-IV (aacC4) and hygromycin B 4-I phosphotransferase (hphB) in bacteria isolated from human and animal sources. Antimicrob. Agents Chemother 1990;34:1915–1920.CrossRefGoogle ScholarPubMed
14. Chaslus-Dancla, E, Pohl, P, Meurisse, M, Marin, M, Lafont, JP. High genetic homology between plasmids of human and animal origins conferring resistance to the aminoglycosides gentamicin and apramycin. Antimicrob Agents Chemother 1991;35:590–593.CrossRefGoogle Scholar
15. Threlfall, EJ, Rowe, B, Ward, LR. A comparison of multiple drug resistance in salmonellas from humans and food animals in England and Wales, 1981 and 1990. Epidemiol Inject 1993;111:189–197.Google Scholar
16. Holmberg, SD, Wells, JG, Cohen, ML. Animal-to-man transmission of antimicrobial-resistant Salmonella: investigations of U.S. outbreaks, 1971. 1983. Science 1984;225:833–835.Google Scholar
17. Holmberg, SD, Osterholm, MT. Senger, KA, Cohen, ML. Drug-resistant Salmonella from animals fed antimicrobials. N Engl J Med 1984;311:617–622.Google Scholar
18. Vollaard, EJ, Clasener, HAL. Colonization resistance. Antimicrob Agents Chemother 1994;38:409–414.Google Scholar