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A Comparison of Pneumonia Caused by Gentamicin, Methicillin-Resistant and Gentamicin, Methicillin-Sensitive Staphylococcus aureus: Epidemiologic and Clinical Studies

Published online by Cambridge University Press:  02 January 2015

Joseph R. Lentino ,
Hani Hennein ,
Sally Krause ,
Sharon Pappas ,
Gail Fuller ,
Doris Schaaff  and
Mary Beth DiCostanzo
Joseph R. Lentino*
Affiliation:
Medical Service, Section of Infectious Disease, the Hospital Infection Surveillance and Control Section, Edward Hines Jr. Veterans Administration Hospital, Hines, Illinois, the Department of Medicine, Loyola University Stritch School of Medicine, Maywood, Illinois, and the Departments of Medicine and Preventive Medicine and Community Health, University of Illinois at Chicago, Chicago, Illinois
Hani Hennein
Affiliation:
Medical Service, Section of Infectious Disease, the Hospital Infection Surveillance and Control Section, Edward Hines Jr. Veterans Administration Hospital, Hines, Illinois, the Department of Medicine, Loyola University Stritch School of Medicine, Maywood, Illinois, and the Departments of Medicine and Preventive Medicine and Community Health, University of Illinois at Chicago, Chicago, Illinois
Sally Krause
Affiliation:
Medical Service, Section of Infectious Disease, the Hospital Infection Surveillance and Control Section, Edward Hines Jr. Veterans Administration Hospital, Hines, Illinois, the Department of Medicine, Loyola University Stritch School of Medicine, Maywood, Illinois, and the Departments of Medicine and Preventive Medicine and Community Health, University of Illinois at Chicago, Chicago, Illinois
Sharon Pappas
Affiliation:
Medical Service, Section of Infectious Disease, the Hospital Infection Surveillance and Control Section, Edward Hines Jr. Veterans Administration Hospital, Hines, Illinois, the Department of Medicine, Loyola University Stritch School of Medicine, Maywood, Illinois, and the Departments of Medicine and Preventive Medicine and Community Health, University of Illinois at Chicago, Chicago, Illinois
Gail Fuller
Affiliation:
Medical Service, Section of Infectious Disease, the Hospital Infection Surveillance and Control Section, Edward Hines Jr. Veterans Administration Hospital, Hines, Illinois, the Department of Medicine, Loyola University Stritch School of Medicine, Maywood, Illinois, and the Departments of Medicine and Preventive Medicine and Community Health, University of Illinois at Chicago, Chicago, Illinois
Doris Schaaff
Affiliation:
Medical Service, Section of Infectious Disease, the Hospital Infection Surveillance and Control Section, Edward Hines Jr. Veterans Administration Hospital, Hines, Illinois, the Department of Medicine, Loyola University Stritch School of Medicine, Maywood, Illinois, and the Departments of Medicine and Preventive Medicine and Community Health, University of Illinois at Chicago, Chicago, Illinois
Mary Beth DiCostanzo
Affiliation:
Medical Service, Section of Infectious Disease, the Hospital Infection Surveillance and Control Section, Edward Hines Jr. Veterans Administration Hospital, Hines, Illinois, the Department of Medicine, Loyola University Stritch School of Medicine, Maywood, Illinois, and the Departments of Medicine and Preventive Medicine and Community Health, University of Illinois at Chicago, Chicago, Illinois
*
Section of Infectious Disease (IIIP), Hines Veterans Administration Hospital, Hines, IL 60141
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Abstract

We investigated an outbreak of nosocomial pneumonia due to gentamicin, methicillin-resistant Staphylococcus aureus (GMRSA). We compared the predisposing factors for pneunomia due to GMRSA to those for pneumonia due to gentamicin, methicillin-sensitive Staphylococcus aureus (GMSSA). Seventeen of 29 patients with staphylococcal pneumonia were infected with GMRSA. Risk factors and associated diseases which selected for infection with GMRSA as opposed to GMSSA included prior antibiotic therapy for a prolonged period of time (p = 0.0001), number of risk factors per patient (p = 0.0001), days hospitalized prior to diagnosis of pneumonia (p = 0.002) and number of associated diseases per patient (p = 0.002).

Despite the epidemiologic differences between GMSSA and GMRSA pneumonia, there were no differences in the clinical presentation, course of illness, complications, response to appropriate therapy or outcome between the two groups. Survival was adversely affected by age only among the GMSSA patients (p = 0.02) and by the number of associated diseases (p = 0.005).

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 6 , Issue 7 , July 1985 , pp. 267 - 272
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1985

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