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A Comparison of Antibiotic Susceptibility Profiles Using Single and Multiple Isolates per Patient

Published online by Cambridge University Press:  02 January 2015

William P. Bennett ,
Michael L. O'Connor  and
Benedict L. Wasilauskas
William P. Bennett
Affiliation:
Department of Pathology, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, North Carolina
Michael L. O'Connor
Affiliation:
Department of Pathology, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, North Carolina
Benedict L. Wasilauskas*
Affiliation:
Department of Pathology, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, North Carolina
*
Department of Pathology, Bowman Gray School of Medicine, 300 S. Hawthorne Road, Winston-Salem, NC 27103
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Abstract

We compared the antibiogram statistics generated by including all clinical isolates to those obtained by tabulating no more than one isolate of a particular organism from a given patient. We found that 48.3% of the isolates presented multiple occurrences in individual patients but found no practical differences in the profiles obtained by the two methods. We also tabulated the occurrence of minimum inhibitory concentration (MIC)-distinct organisms among the sets of multiple isolates of E. coli and of S. aureus and found that only 20.9% of those isolates represented duplicate organisms by MIC profile. This heterogeneity of MIC sensitivity that occurs in multiple isolates from individual patients was not expected but provides an explanation for the lack of difference between the two methods of tabulating antibiotic susceptibility statistics.

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 6 , Issue 4 , April 1985 , pp. 157 - 160
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1985

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References

1.National Committee for Clinical Laboratory Standards: Proposed Standard PSM-7. Standard methods for dilution antimicrobial susceptibility tests for bacteria which grow aerobically (proposed). July 1980.Google Scholar