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Clinical and Laboratory Studies of Nosocomial Staphylococcus aureus Resistant to Methicillin and Aminoglycosides

Published online by Cambridge University Press:  02 January 2015

Bonnie V. Bock ,
Karen Pasiecznik  and
Richard D. Meyer
Bonnie V. Bock
Affiliation:
Infectious Disease Section, Research and Medical Services, Veterans Administration, Wadsworth Hospital Center and the Department of Medicine, UCLA School of Medicine, Los Angeles, California
Karen Pasiecznik
Affiliation:
Infectious Disease Section, Research and Medical Services, Veterans Administration, Wadsworth Hospital Center and the Department of Medicine, UCLA School of Medicine, Los Angeles, California
Richard D. Meyer*
Affiliation:
Infectious Disease Section, Research and Medical Services, Veterans Administration, Wadsworth Hospital Center and the Department of Medicine, UCLA School of Medicine, Los Angeles, California
*
Infectious Disease Section (691/111F) Bldg. 500, Room 3658, Wadsworth V.A. Medical Center, Los Angeles, California 90073
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Abstract

A methicillin/aminoglycoside-resistant strain of Staphylococcus aureus (MARS) was likely introduced by transfer of a patient from another hospital. Over the next year, 20 other patients were colonized or infected with MARS of the same phage type, although antibiograms varied. Affected patients usually had serious underlying disease and were in intensive care units. Vancomycin therapy was frequently delayed and MARS may have contributed to the death of some patients. The mode of spread was not definitively delineated, but two nurses were found to be colonized. Institution of isolation procedures was difficult, but the problem gradually waned.

Susceptibility testing showed vancomycin to be the most active agent. Synergy studies showed no consistent effect of combining methicillin with an aminoglycoside. This experience illustrates the problem of MARS spread between hospitals and wards, the need for institution of effective control measures, and consideration of early empiric use of vancomycin.

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 3 , Issue 3 , June 1982 , pp. 224 - 229
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1982

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