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The Cephalosporin Antibiotic Agents — II. First- and Second-Generation Agents

Published online by Cambridge University Press:  02 January 2015

T. Donald Marsh
T. Donald Marsh*
Affiliation:
Shenandoah Shared Hospital Services, Inc., Harrisonburg, Virginia
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Extract

The first article in this series discussed the cephalosporin antibiotic agents as a class, including the similarities in their structure, antimicrobial action, and toxicity. Part II focuses on the difference between commercially available first- and second-“generation” agents.

The cephalosporins are classified using various criteria, including vulnerability to beta-lactamase hydrolysis and antibacterial activity. The latter classification is based on the in vitro activity of the individual agents, with each succeeding “generation” possessing a greater spectrum of activity than the previous generation(s).

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 5 , Issue 12 , December 1984 , pp. 577 - 582
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1984

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References

1.Garzone, P, Lyon, J, Yu, VL: Third-generation and investigational cephalosporins: Structure-activity relationships and pharmacokinetic review. Drug Intell Clin Pharm 1983;17:507–515.Google Scholar
2.Bertino, JS, Speck, WT: The cephalosporin antibiotics. Pediatr Clin North Am 1983;30:17–26.CrossRefGoogle ScholarPubMed
3.Thompson, RL, Wright, AJ: Cephalosporin antibiotics. Mayo Clin Proc 1983;58:79–87.Google Scholar
4.Barza, M, Miao, PVW: Cephalosporins. Am J Hosp Pharm 1977;34:621–629.Google ScholarPubMed
5.Gillett, AP, Wise, R, Andrews, JM: Comparative in vitro microbiological activity and stability of cefaclor. Postgrad Med J 1979; 55 (suppl 4):9–11.Google ScholarPubMed
6.Crenshaw, CA, Glanges, E, Webber, CE, et al: A prospective, randomized, double-blind study of preventive cefamandole therapy in patients at high risk for undergoing cholecystectomy. Surg Gynecol Obstet 1981;153:546–552.Google Scholar
7.Preblud, SR, Gill, CJ, Campos, JM: Bactericidal activities of chloramphenicol and eleven other antibiotics against Salmonella spp. Antimicrob Agents Chemother 1984;25:327–330.Google Scholar
8.LeFrock, JL, Schell, RF, Carr, BB, et al: Cefoxitin therapy in aerobic, anaerobic, and mixed aerobic-anaerobic infections. Drug Intell Clin Pharm 1982;16:306–312.Google Scholar
9.Garcia, MJ, Dominguez-Gil, A, Tabernero, JM, et al: Pharmacokinetics of cefoxitin in patients undergoing hemodialysis. International Journal of Clinical Pharmacology, Biopharmacology 1979;17:366–370.Google Scholar
10.Tally, FP, Miao, PVM, O'Keefe, JP, et al: Cefoxitin therapy of anaerobic and aerobic infection. J Antimicrob Chemother 1979;5:101–108.CrossRefGoogle Scholar
11.Geelhoed, GW, Simon, GL: Systemic antibiotic therapy in surgical patients. South Med J 1984;77:355–359.Google Scholar
12.Brunham, RC: Therapy for acute pelvic inflammatory disease: A critique of recent treatment trials. Am J Obstet Gynecol 1984;148:235–240.Google Scholar
13.Cefuroxime Sodium (Zinacef) Med Lett Drugs Ther 1984;26:15–16.Google Scholar
14.Sirinavin, S, Chiemchanya, S, Visudhipan, P, et al: Cefuroxime treatment of bacterial meningitis in infants and children. Antimicrob Agents Chemother 1984;25:273–275.Google Scholar
15.Garzone, P, Lyon, J, Yu, VL: Third-generation and investigational cephalosporins: Microbiologic review and clinical summaries. Drug Intell Clin Pharm 1983;17:615–622.Google Scholar
16.Dudley, MN, Quintiliani, R, Nightingale, CH: Review of cefonicid, a long-acting cephalosporin. Clin Pharm 1984;3:23–32.Google Scholar
17.Barriere, SL, Mills, J: Ceforanide: Antibacterial activity, pharmacology, and clinical efficacy. Pharmacotherapy 1982;2:322–327.Google Scholar
18.Nightingale, CH, French, MA, Quintiliani, R: Cephalosporins, in Evans, WE, Schentag, JJ, Jusko, WJ (eds): Applied Pharmacokinetics: Principles of Therapeutic Drug Monitoring. Spokane, WA, Applied Therapeutics Inc, 1980.Google Scholar
19.Nightingale, CH, Greene, DS, Quintiliani, R: Pharmacokinetics and clinical use of cephalosporin antibiotics. J Pharm Sci 1975;64:1899–1927.Google Scholar
20.Moellering, RC, Swartz, MN: Drug Therapy; The newer cephalosporins. N Engl J Med 1976;294:24–28.Google Scholar
21.Brogard, JM, Comte, F: Pharmacokinetics of the new cephalosporins. Antibiol Chemother 1982;31:145–210.Google Scholar
22.McCracken, GH, Ginsburg, CM, Clarkson, JC, et al: Pharmacokinetics of cefaclor in infants and children. J Antimicrob Chemother 1978;4:515–521.Google Scholar
23.Quintiliani, R, Nightingale, CH: Cefazolin. Ann Intern Med 1978; 89(part 1):650–656.Google Scholar
24.Estey, EH, Weaver, SS, LeBlanc, BM, et al: Ceforanide kinetics. Clin Pharmacol Ther 1981;30:398–403.Google Scholar
25.Kenady, DE, Ram, MD: Biliary levels of ceforanide. Antimicrob Agents Chemother 1983;23:706–709.Google Scholar
26.Thomas, M, Browning, AK, McFarland, RJ: Excretion of cefuroxime in biliary disease. Surg Gynecol Obstet 1984;158:272–274.Google ScholarPubMed
27.Fitzgerald, RH, Thompson, RL: Cephalosporin antibiotics in the prevention and treatment of musculoskeletal sepsis. J Bone and Joint Surg 1983; 65A:1201–1205.Google Scholar
28.Smith, BR, LeFrock, JL: Bronchial tree penetration of antibiotics. Chest 1983;83:904–908.CrossRefGoogle ScholarPubMed
29.Leed, CC, Marbury, TC: Drug therapy in patients undergoing haemodialysis: Clinical pharmacokinetic considerations. Clin Pharmacokinet 1984;9:42–66.Google Scholar
30.Bennett, WM, Muther, RS, Parker, RA, et al: Drug therapy in renal failure: Dosing guidelines for adults. Ann Intern Med 1980;93:62–89.Google Scholar
31.Quintiliani, R, French, M, Nightingale, CH: First and second generation cephalosporins. Med Clin North Am 1982;66:183–197.CrossRefGoogle ScholarPubMed
32.Marsh, TD: The cephalosporin antibiotic agents—I. Considered as a group. Infect Control 1984;5:493–496.Google Scholar
33.Wong, R, Gee, CL, Ledger, WJ: Prophylactic use of cefazolin in monitored obstetric patients undergoing cesarean section. Obstet Gynecol 1978;51:407–411.Google Scholar
34.DiPiro, JT, Record, KE, Bivins, BA: Evaluation of new cephalosporins for prophylaxis of surgical infection Clin Pharm 1982;1:135–140.Google Scholar
35.Stiver, HG, Forward, KR, Livingstone, RA, et al: Multicenter comparison of cefoxitin vs. cefazolin for prevention of infectious morbidity after nonelective cesarean section. Am J Obstet Gynecol 1983;145:158–163.Google Scholar
36.Rehm, SJ, McHenry, MC: Oral antimicrobial drugs. Med Clin North Am 1983;67:57–98.Google Scholar
37.Aronovitz, GH: Treatment of otitis media with cefaclor, a new oral cephalosporin. South Med J 1980;73:1447–1449.Google Scholar
38.Murray, DL, Singer, DA, Singer, AB, et al: Cefaclor—A cluster of adverse reactions. N Engl J Med 1980;303:1003.Google ScholarPubMed
39.Ackley, AM, Felsher, J: Adverse reactions to cefaclor. South Med J 1981;74:1550.CrossRefGoogle ScholarPubMed
40.Humbert, G: Pharmacokinetics of Cefadroxil in normal subjects and in patients with renal insufficiency. Infection 1980; (suppl 5):1S598.Google Scholar
41.Barriere, SL: “Long-acting” cephalosporins: Cost effective but efficacy questionable. Clin Pharm 1984;3:78.Google Scholar
42.Nelson, JD: A primer for pediatricians on new cephalosporin antibiotics. Am J Dis Child 1983;137:1041–1042.Google Scholar
43.Quinn, EL, Madhavan, T, Wixson, R, et al: Cefamandole: Observations on its spectrum, concentration in bone and bile, excretion in renal failure, and clinical efficacy. Current Chemotherapy 1978; 803–804.Google Scholar
44.Griffith, RS, Black, HR, Brier, GL, et al: Cefamandole: In vitro and clinical pharmacokinetics. Antimicrob Agents Chemother 1976;10:814–823.Google Scholar
45.Guglielmo, J, Hohn, DC, Koo, PJ, et al: Antibiotic prophylaxis in surgical procedures. Arch Surg 1983;118:943–955.Google Scholar
46.Rymer, W, Greenlaw, CW: Hypoprothrombinemia associated with cefamandole. Drug Intell Clin Pharm 1980;14:780–783.Google Scholar
47.Angaran, DM, Dias, VC, Arom, KV, et al: The influence of prophylactic antibiotics on the warfarin anticoagulation response in the postoperative prosthetic cardiac valve patient. Ann Surg 1984;199:107–111.Google Scholar
48.Tally, FP, McGowan, K, Kellum, JM, et al: A randomized comparison of cefoxitin with or without amikacin and clindamycin plus amikacin in surgical sepsis. Ann Surg 1981;193:318–323.Google Scholar
49.DeTorres, OH: Hemolytic anemia and pancytopenia induced by cefoxitin. Drug Intell Clin Pharm 1983;17:816–818.Google Scholar
50.Tietze, KJ, Gaska, JA: Cefoxitin-associated exfoliative dermatitis. Clin Pharm 1983;2:582–584.Google ScholarPubMed
51.Conte, JE, Barriere, SL (eds): Manual of Antibiotics and Infectious Diseases. Philadelphia, PA, Lea & Febiger. 1984.Google Scholar
52.Sommers, D, Van Wyk, M, Williams, PEO, et al: Pharmacokinetics and tolerance of cefuroxime axetil in volunteers during repeated dosing. Antimicrob Agents Chemother 1984;25:344–347.CrossRefGoogle ScholarPubMed
53.Harding, SM, Williams, PEO, Ayrton, J: Pharmacology of cefuroxime as the 1-acetoxyethyl ester in volunteers. Antimicrob Agents Chemother 1984;25:78–82.CrossRefGoogle ScholarPubMed
54.Dudley, MN, Nightingale, CH, Quintiliani, R, et al: In vitro activity of cefonicid, ceforanide, and cefazolin against Staphylococcus aureus and Staphylococcus epidermidis and the effect of human serum. J Infect Dis 1983;148:178.Google Scholar
55.Pontzer, RE, Krieger, RE, Bosscia, JA, et al: Single-dose cefonicid therapy for urinary tract infections. Antimicrob Agents Chemother 1983;23:814–816.Google Scholar