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Bacillus cereus infection in neonates and the absence of evidence for the role of banked human milk: Case reports and literature review

Published online by Cambridge University Press:  07 June 2019

Antoine Lewin ,
Caroline Quach ,
Virginie Rigourd ,
Jean-Charles Picaud ,
Thérèse Perreault ,
Pierre Frange ,
Marc-Christian Domingo ,
Cindy Lalancette ,
Gilles Delage  and
Marc Germain
Antoine Lewin*
Affiliation:
Medical Affairs and Innovation, Héma-Québec, Montréal, Québec, Canada Department of Obstetrics and Gynecology, University of Sherbrooke, Sherbrooke, Québec, Canada
Caroline Quach
Affiliation:
Department of Microbiology, Infectious Diseases and Immunology, University of Montreal, Montreal, Québec, Canada Infection Control and Prevention Unit, Department of Pediatric Laboratory Medicine, CHU Sainte-Justine, University of Montreal, Montreal, Québec, Canada Department of Epidemiology and Biostatistics, McGill University, Montreal, Québec, Canada
Virginie Rigourd
Affiliation:
Région Île-de-France Human Milk Bank, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France
Jean-Charles Picaud
Affiliation:
Department of Neonatology, Croix Rousse Hospital, Hospices Civils de Lyon, Lyon, France, and CarMeN Unit, INSERM U1060, INRA U1397, Claude Bernard University Lyon 1, Pierre Bénite, France
Thérèse Perreault
Affiliation:
Department of Neonatology and Department of Pediatrics, The Montreal Children’s Hospital, Montreal, Québec, Canada
Pierre Frange
Affiliation:
Laboratory of clinical microbiology, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France Paris Descartes University, Sorbonne Paris Cité, Paris, France
Marc-Christian Domingo
Affiliation:
Laboratoire de santé publique du Québec, Sainte-Anne-de-Bellevue, Québec, Canada
Cindy Lalancette
Affiliation:
Laboratoire de santé publique du Québec, Sainte-Anne-de-Bellevue, Québec, Canada
Gilles Delage
Affiliation:
Medical Affairs and Innovation, Héma-Québec, Montréal, Québec, Canada
Marc Germain
Affiliation:
Medical Affairs and Innovation, Héma-Québec, Québec, Québec, Canada
*
Author for correspondence: Antoine Lewin, E-mail: [email protected]
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Abstract

Background:

Banked human milk (BHM) has inherent infectious risks, even when pasteurized. Because of the ubiquity of Bacillus cereus in the environment and its ability to resist the Holder pasteurization process, there is a concern that BHM might lead to severe B. cereus infections.

Objective:

We reviewed observed and published cases to determine the potential causal role of BHM as the source of these infections.

Methods:

Two infants in the province of Québec (Canada) developed a B. cereus neonatal infection, and both had received BHM. We conducted bacteriological studies to compare clinical isolates and those found in these cases.

Results:

After extended culture of BHM retention lots, B. cereus was found to have been involved in batches related to the first case. However, molecular typing showed that the strain was different from the clinical isolate, therefore excluding BHM as the source of contamination. In the second case, a Brevibacillus spp was isolated, a species distinct from the clinical isolate.

Conclusion:

Based on these cases and others reported in the literature, a causal link between B. cereus contaminated BHM and preterm neonatal infection has never been documented. Therefore, the risk that BHM can cause this infection remains theoretical. Given the widespread presence of B. cereus in the hospital environment and its capacity to resist standard cleaning procedures, it seems likely that airborne or direct or indirect contact are the main sources of most, if not all, cases of severe B. cereus neonatal infections, even in babies exposed to BHM.

Type
Original Article
Information
Infection Control & Hospital Epidemiology , Volume 40 , Issue 7 , July 2019 , pp. 787 - 793
Copyright
© 2019 by The Society for Healthcare Epidemiology of America. All rights reserved 

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References

Furman, L, Taylor, G, Minich, N, Hack, M. The effect of maternal milk on neonatal morbidity of very low-birth-weight infants. Arch Pediatr Adolesc Med 2003;157:66–71.CrossRefGoogle ScholarPubMed
Ronnestad, A, Abrahamsen, TG, Medbo, S, et al. Late-onset septicemia in a Norwegian national cohort of extremely premature infants receiving very early full human milk feeding. Pediatrics 2005;115:e269–e276.CrossRefGoogle Scholar
Schanler, RJ, Shulman, RJ, Lau, C. Feeding strategies for premature infants: beneficial outcomes of feeding fortified human milk versus preterm formula. Pediatrics 1999;103:1150–1157.CrossRefGoogle ScholarPubMed
Henderson, G, Craig, S, Brocklehurst, P, McGuire, W. Enteral feeding regimens and necrotising enterocolitis in preterm infants: a multicentre case-control study. Arch Dis Child Fetal Neonatal Ed 2009;94: F120–F123.CrossRefGoogle ScholarPubMed
Sisk, PM, Lovelady, CA, Dillard, RG, Gruber, KJ, O’shea, TM. Early human milk feeding is associated with a lower risk of necrotizing enterocolitis in very low birth weight infants. J Perinatol 2007;27:428–433.CrossRefGoogle ScholarPubMed
Bier, JA, Oliver, T, Ferguson, AE, Vohr, BR. Human milk improves cognitive and motor development of premature infants during infancy. J Hum Lact 2002;18:361–367.CrossRefGoogle ScholarPubMed
O’Connor, DL, Jacobs, J, Hall, R, et al. Growth and development of premature infants fed predominantly human milk, predominantly premature infant formula, or a combination of human milk and premature formula. J Pediatr Gastroenterol Nutr 2003;37:437–446.CrossRefGoogle ScholarPubMed
Singhal, A, Cole, TJ, Fewtrell, M, Lucas, A. Breastmilk feeding and lipoprotein profile in adolescents born preterm: follow-up of a prospective randomised study. Lancet 2004;363:1571–1578.CrossRefGoogle ScholarPubMed
Singhal, A, Cole, TJ, Lucas, A. Early nutrition in preterm infants and later blood pressure: two cohorts after randomised trials. Lancet 2001;357:413–419.CrossRefGoogle ScholarPubMed
Gartner, LM, Morton, J, Lawrence, RA, et al. Breastfeeding and the use of human milk. Pediatrics 2005;115:496–506.Google ScholarPubMed
Arslanoglu, S, Ziegler, EE, Moro, GE. Donor human milk in preterm infant feeding: evidence and recommendations. J Perinat Med 2010; 38:347–351.Google ScholarPubMed
Kim, J, Unger, S. Human milk banking. Paediatr Child Health 2010;15: 595–598.CrossRefGoogle ScholarPubMed
Decousser, JW, Ramarao, N, Duport, C, et al. Bacillus cereus and severe intestinal infections in preterm neonates: putative role of pooled breast milk. Am J Infect Control 2013;41:918–921.CrossRefGoogle ScholarPubMed
Dewitte, C, Courdent, P, Charlet, C, Dumoulin, D, Courcol, R, Pierrat, V. Contamination of human milk with aerobic flora: Evaluation of losses for a human milk bank. Arch Pediatr 2015;22:461–467.CrossRefGoogle ScholarPubMed
Landers, S, Updegrove, K. Bacteriological screening of donor human milk before and after Holder pasteurization. Breastfeed Med 2010;5:117–121.CrossRefGoogle ScholarPubMed
Bottone, EJ. Bacillus cereus, a volatile human pathogen. Clin Microbiol Rev 2010;23:382–398.CrossRefGoogle ScholarPubMed
Hilliard, NJ, Schelonka, RL, Waites, KB. Bacillus cereus bacteremia in a preterm neonate. J Clin Microbiol 2003;41:3441–3444.CrossRefGoogle Scholar
Lebessi, E, Dellagrammaticas, HD, Antonaki, G, Foustoukou, M, Iacovidou, N. Bacillus cereus meningitis in a term neonate. J Matern Fetal Neonatal Med 2009;22:458–461.CrossRefGoogle Scholar
Ramarao, N, Belotti, L, Deboscker, S, et al. Two unrelated episodes of Bacillus cereus bacteremia in a neonatal intensive care unit. Am J Infect Control 2014;42:694–695.CrossRefGoogle Scholar
Lotte, R, Herisse, AL, Berrouane, Y, et al. Virulence analysis of Bacillus cereus isolated after death of preterm neonates, Nice, France, 2013. Emerg Infect Dis 2017;23:845–848.CrossRefGoogle Scholar
Van Der Zwet, WC, Parlevliet, GA, Savelkoul, PH, et al. Outbreak of Bacillus cereus infections in a neonatal intensive care unit traced to balloons used in manual ventilation. J Clin Microbiol 2000;38:4131–4136.Google Scholar
Wiedermann, BL. Non-anthrax Bacillus infections in children. Pediatr Infect Dis J 1987;6:218–220.Google ScholarPubMed
Human Milk Banking Association of North America (HMBANA). Guidelines for the Establishment and Operation of a Donor Human Milk Bank. Sandwich, MA: HMBANA; 2018.Google Scholar
Centre for Clinical Practice at NICE (UK). Donor breast milk banks: the operation of donor milk bank services. National Institute for Health and Clinical Excellence: Guidance 2010.Google Scholar
Hartmann, BT, Pang, WW, Keil, AD, Hartmann, PE, Simmer, K. Best practice guidelines for the operation of a donor human milk bank in an Australian NICU. Early Hum Dev 2007;83:667–673.CrossRefGoogle Scholar
The director of the french health care product safety agency. The good pratice rules for the collection, preparation, qualification, treatment, storage, distribution and dispensing on medical prescription of human milk by the milk banks. In: Code Ph, ed. Vol L.2323-1. Paris: Dalloz; 2007.Google Scholar
Fischknecht, K, Wälchli, C, Annen, V, Fuhrer, T, Gianoli, P, Stocker, M. Recommandations pour l’organisation et le fonctionnement d’une banque de lait en Suisse. Paediatrica 2010;21:24–28.Google Scholar
Maslow, JN, Slutsky, AM, Arbeit, RD. Application of pulsed-field gel electrophoresis to molecular epidemiology. In: Persing DH (editor). Diagnostic molecular microbiology: principles and applications. Washington, DC: American Society for Microbiology; 1993.Google Scholar
Castiaux, V, N’Guessan, E, Swiecicka, I, Delbrassinne, L, Dierick, K, Mahillon, J. Diversity of pulsed-field gel electrophoresis patterns of cereulide-producing isolates of Bacillus cereus and Bacillus weihenstephanensis. FEMS Microbiol Lett 2014;353:124–131.CrossRefGoogle ScholarPubMed
Birch, BR, Perera, BS, Hyde, WA, et al. Bacillus cereus cross-infection in a maternity-unit. J Hosp Infect 1981;2:349–354.CrossRefGoogle Scholar
Gray, J, George, RH, Durbin, GM, Ewer, AK, Hocking, MD, Morgan, ME. An outbreak of Bacillus cereus respiratory tract infections on a neonatal unit due to contaminated ventilator circuits. J Hosp Infect 1999;41:19–22.CrossRefGoogle ScholarPubMed
Kembel, SW, Jones, E, Kline, J, et al. Architectural design influences the diversity and structure of the built environment microbiome. ISME J 2012;6:1469–1479.CrossRefGoogle ScholarPubMed
Youngs, ER, Roberts, C, Kramer, JM, Gilbert, RJ. Dissemination of Bacillus cereus in a maternity unit. J Infect 1985;10:228–232.CrossRefGoogle Scholar
Hosein, IK, Hoffman, PN, Ellam, S, et al. Summertime Bacillus cereus colonization of hospital newborns traced to contaminated, laundered linen. J Hosp Infect 2013;85:149–154.CrossRefGoogle ScholarPubMed
Wendelboe, AM, Smelser, C, Lucero, CA, McDonald, LC. Cluster of necrotizing enterocolitis in a neonatal intensive care unit: New Mexico, 2007. Am J Infect Control 2010;38:144–148.CrossRefGoogle Scholar
Fournier, S, Faraut-Derouin, V, Casetta, A, et al. Bacillus cereus bacteremia in neonatal resuscitation at ap-hp (france) in 2016. Buletin épidémiologique hebdomadaire 2018:536–540.Google Scholar
Barrie, D, Hoffman, PN, Wilson, JA, Kramer, JM. Contamination of hospital linen by Bacillus cereus. Epidemiol Infect 1994;113:297–306.CrossRefGoogle ScholarPubMed
Sasahara, T, Hayashi, S, Morisawa, Y, Sakihama, T, Yoshimura, A, Hirai, Y. Bacillus cereus bacteremia outbreak due to contaminated hospital linens. Eur J Clin Microbiol Infect Dis 2011;30:219–226.CrossRefGoogle ScholarPubMed
Turabelidze, G, Gee, JE, Hoffmaster, AR, et al. Contaminated ventilator air flow sensor linked to Bacillus cereus colonization of newborns. Emerg Infect Dis 2013;19:781–783.CrossRefGoogle ScholarPubMed
Rigourd, V, Barnier, JP, Ferroni, A, et al . Recent actuality about Bacillus cereus and human milk bank: a new sensitive method for microbiological analysis of pasteurized milk. Eur J Clin Microbiol Infect Dis 2018;37: 1297–1303.CrossRefGoogle ScholarPubMed
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