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Antibiotic Overuse is a Major Risk Factor for Clostridium difficile Infection in Surgical Patients

Published online by Cambridge University Press:  31 July 2017

James T. Bernatz ,
Nasia Safdar ,
Scott Hetzel  and
Paul A. Anderson
James T. Bernatz*
Affiliation:
Department of Orthopedics and Rehabilitative Medicine; University of Wisconsin School of Medicine & Public Health, Madison, Wisconsin
Nasia Safdar
Affiliation:
Department of Medicine, Division of Infectious Disease, University of Wisconsin School of Medicine & Public Health, Madison, Wisconsin William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin
Scott Hetzel
Affiliation:
Department of Biostatistics and Medical Informatics, University of Wisconsin–Madison, Madison, Wisconsin.
Paul A. Anderson
Affiliation:
Department of Orthopedics and Rehabilitative Medicine; University of Wisconsin School of Medicine & Public Health, Madison, Wisconsin
*
Address correspondence to James Bernatz, MD, UW Medical Foundation Centennial Buildingm 1685 Highland Avenue, 6th Floor, Madison, WI 53705-2281 ([email protected]).
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Abstract

Clostridium difficile infection (CDI) is associated with increased cost, morbidity, and mortality in postoperative patients. Variable rates of postoperative CDI are reported among 4 surgical specialties during the 30-month study period. Risk factors for CDI include antibiotic use, increased ASA score, and increased admissions in the past year.

Infect Control Hosp Epidemiol 2017;38:1254–1257

Type
Concise Communications
Information
Infection Control & Hospital Epidemiology , Volume 38 , Issue 10 , October 2017 , pp. 1254 - 1257
Copyright
© 2017 by The Society for Healthcare Epidemiology of America. All rights reserved 

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References

REFERENCES

1. Maltenfort, MG, Rasouli, MR, Morrison, TA, Parvizi, J. Clostridium difficile colitis in patients undergoing lower-extremity arthroplasty: rare infection with major impact. Clin Orthop Relat Res 2013;471:3178–3185.Google Scholar
2. Sharma, P, Bomireddy, R, Phillips, S. Clostridium difficile-associated diarrhoea after internal fixation of intertrochanteric femoral fractures. Eur J Clin Microbiol Infect Dis 2003;22:615–618.Google Scholar
3. Damle, RN, Cherng, NB, Flahive, JM, et al. Clostridium difficile infection after colorectal surgery: a rare but costly complication. J Gastrointest Surg 2014;18:1804–1811.Google Scholar
4. Dasenbrock, HH, Bartolozzi, AR, Gormley, WB, Frerichs, KU, Aziz-Sultan, MA, Du, R. Clostridium difficile infection after subarachnoid hemorrhage: a nationwide analysis. Neurosurgery 2016;78:412–420.Google Scholar
5. Egorova, NN, Siracuse, JJ, McKinsey, JF, Nowygrod, R. Trend, risk factors, and costs of Clostridium difficile infections in vascular surgery. Ann Vasc Surg 2015;29:792–800.Google Scholar
6. Guzman, JZ, Skovrlj, B, Rothenberg, ES, et al. The burden of Clostridium difficile after cervical spine surgery. Global Spine J 2016;6:314–321.Google Scholar
7. Krapohl, GL, Morris, AM, Cai, S, et al. Preoperative risk factors for postoperative Clostridium difficile infection in colectomy patients. Am J Surg 2013;205:343–347; discussion 347–348.CrossRefGoogle ScholarPubMed
8. Shah, K, Pass, LA, Cox, M, Lanham, M, Arnold, FW. Evaluating contemporary antibiotics as a risk factor for Clostridium difficile infection in surgical trauma patients. J Trauma Acute Care Surg 2012;72:691–695.CrossRefGoogle ScholarPubMed
9. Zacharioudakis, IM, Zervou, FN, Pliakos, EE, Ziakas, PD, Mylonakis, E. Colonization with toxinogenic C. difficile upon hospital admission, and risk of infection: a systematic review and meta-analysis. Am J Gastroenterol 2015;110:381–390; quiz 391.Google Scholar
10. Lewallen, S, Courtright, P. Epidemiology in practice: case-control studies. Community Eye Health 1998;11:57–58.Google ScholarPubMed