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Transient Detection of Plasma HIV-1 RNA During Postexposure Prophylaxis

Published online by Cambridge University Press:  02 January 2015

Vincenzo Puro ,
Giuseppe Calcagno ,
Marco Anselmo ,
Gisella Benvenuto ,
Daria Trabattoni ,
Mario Clerici  and
Giuseppe Ippolito
Vincenzo Puro*
Affiliation:
IRCCS Lazzaro Spallanzani, Roma, Milano, Italy
Giuseppe Calcagno
Affiliation:
Ospedale S. Paolo, Milano, Italy
Marco Anselmo
Affiliation:
Ospedale S. Paolo, Milano, Italy
Gisella Benvenuto
Affiliation:
Ospedale S. Paolo, Milano, Italy
Daria Trabattoni
Affiliation:
Universitá degli Studi, Milano, Italy
Mario Clerici
Affiliation:
Universitá degli Studi, Milano, Italy
Giuseppe Ippolito
Affiliation:
IRCCS Lazzaro Spallanzani, Roma, Milano, Italy
*
IRCCS “Lazzaro Spallanzani, ” Centro di Riferimento AIDS, Servizio di Epidemiologia delle Malattie Infettive, Via Portuense, 292-00149 Rome, Italy
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Abstract

Transient plasma human immunodeficiency virus (HIV) copies were detected by nucleic-acid sequence-based amplification during combination antiretroviral prophylaxis in a healthcare worker who reported a percutaneous injury from a stylet and who remained HIV-antibody-negative. An HIV-specific T-helper response, assessed by interleukin-2 production, was observed when tested at 13 months following the exposure.

Type
Concise Communications
Information
Infection Control & Hospital Epidemiology , Volume 21 , Issue 8 , August 2000 , pp. 529 - 531
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2000

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References

1.Centers for Disease Control and Prevention. Public Health Service guidelines for the management of health-care worker exposures to HIV and recommendations for postexposure prophylaxis. MMWR 1998;47(RR-7):1–33.Google Scholar
2.Clerici, M, Levin, JM, Kessler, HA, Harris, A, Berzofsky, JA, Landay, AL, et al. HIV-specific T-helper activity in seronegative health care workers exposed to contaminated blood. JAMA 1994;271:42–46.CrossRefGoogle ScholarPubMed
3.Ippolito, G, Puro, V, De Carli, G. The risk of occupational HIV infection in health care workers. Italian Multicenter Study. The Italian Study Group on Occupational Risk of HIV Infection. Arch Intern Med 1993;153:1451–1458.CrossRefGoogle ScholarPubMed
4.Cardo, DM, Culver, DH, Ciesielski, CA, Srivastava, PU, Marcus, R, Abiteboul, D, et al. A case-control study of HIV seroconversion in health care workers after percutaneous exposure. Centers for Disease Control and Prevention Needlestick Surveillance Group. N Engl J Med 1997;337:1485–1490.CrossRefGoogle ScholarPubMed
5.Pinto, LA. Landay, AL, Berzofsky, JA, Kessler, HA, Shearer, GM. Immune response to human immunodeficiency virus (HIV) in healthcare workers occupationally exposed to HIV-contaminated blood. Am J Med 1997;102(5B):21–24.CrossRefGoogle ScholarPubMed
6.D'Amico, R, Pinto, LA, Meyer, P, Landay, AL, Harris, AA, Clerici, M, et al. Effect of zidovudine postexposure prophylaxis on the development of HIV-specific cytotoxic T-lymphocyte responses in HIV-exposed healthcare workers. Infect Control Hosp Epidemiol 1999; 20:428–430.CrossRefGoogle ScholarPubMed
7.Rich, JD, Merriman, NA, Mylonakis, E, Greenough, TC, Flanigan, TP, Mady, BJ, et al. Misdiagnosis of HIV infection by HIV-1 plasma viral load testing: a case series. Ann Intern Med 1999;130:37–39.CrossRefGoogle ScholarPubMed
8.Schwartz, DH, Laeyendecker, OB, Arango-Jaramillo, S, Castillo, RC, Reynolds, MJ. Extensive evaluation of a seronegative participant in an HIV-1 vaccine trial as a result of false positive PCR. Lancet 1997;350:256–259.CrossRefGoogle Scholar
9.de Mendoza, C, Holguin, A, Soriano, V. False positive for HIV using commercial viral load quantification assays. AIDS 1998;12:2076–2077.CrossRefGoogle ScholarPubMed