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Surveillance for Nosocomial and Central Line-Related Infections Among Pediatric Hematology-Oncology Patients

Published online by Cambridge University Press:  02 January 2015

Arne Simon ,
Gudrun Fleischhack ,
Carola Hasan ,
Udo Bode ,
Steffen Engelhart  and
Michael H. Kramer
Arne Simon
Affiliation:
Department of Pediatric Hematology and Oncology, University of Bonn, Bonn, Germany
Gudrun Fleischhack
Affiliation:
Department of Pediatric Hematology and Oncology, University of Bonn, Bonn, Germany
Carola Hasan
Affiliation:
Department of Pediatric Hematology and Oncology, University of Bonn, Bonn, Germany
Udo Bode
Affiliation:
Department of Pediatric Hematology and Oncology, University of Bonn, Bonn, Germany
Steffen Engelhart
Affiliation:
Institute for Hygiene, University of Bonn, Bonn, Germany
Michael H. Kramer*
Affiliation:
Institute for Hygiene, University of Bonn, Bonn, Germany
*
Field Epidemiology Training Program, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo 162-8640, Japan
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Abstract

Objective:

To determine the incidence of all nosocomial infections (NIs) in pediatric hematology-oncology patients, as well as central venous access device (CVAD)-associated infections acquired during home care.

Design:

Prospective surveillance study.

Setting:

The Pediatric Hematology and Oncology Department at the University Hospital Bonn.

Patients:

All patients admitted from January through October 1998 (surveillance period).

Methods:

Standardized surveillance system based on the Centers for Disease Control and Prevention's National Nosocomial Infections Surveillance System.

Results:

A total of 143 patients were hospitalized for 3,701 days (776 admissions) during the surveillance period. Of the 40 NIs detected, 26 were CVAD-related, with 21 bloodstream infections (BSIs) and 5 local infections. Four were Clostridium difficile-associated diarrheal illnesses, 3 were pneumonias, and 7 were other infections. The incidence of NIs was 10.8 per 1,000 patient-days (5.2 NIs/100 admissions). The overall CVAD-related BSI rate was 7.4 per 1,000 utilization days, without a significant difference between implanted infusion ports and tunneled catheters. In addition, 7 CVAD-related infections occurred during home care. All 8 BSIs associated with tunneled catheters and 13 (76%) of the 17 BSIs associated with ports were acquired nosocomially. For inpatients and outpatients combined, the exit sites of tunneled catheters were more likely to become locally infected than were the needle entry sites of ports (relative risk, 8.0; P=.007). In 30 (75%) of the 40 NIs, the affected patients had severe neutropenia (<500/mm3) at the time of infection.

Conclusions:

Most NIs in the pediatric hematology-oncology patients were associated with CVAD devices. Although many infections in this high-risk population may not be preventable through infection control measures, the careful evaluation of specific infection rates permits the identification of risk factors that may be targeted by infection control programs. Prospective surveillance for NIs on pediatric oncology units is an indispensable tool for this internal quality control.

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 21 , Issue 9 , September 2000 , pp. 592 - 596
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2000

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