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Six-year multicenter study on short-term peripheral venous catheters-related bloodstream infection rates in 727 intensive care units of 268 hospitals in 141 cities of 42 countries of Africa, the Americas, Eastern Mediterranean, Europe, South East Asia, and Western Pacific Regions: International Nosocomial Infection Control Consortium (INICC) findings

Published online by Cambridge University Press:  18 March 2020

Víctor Daniel Rosenthal ,
Ider Bat-Erdene ,
Debkishore Gupta ,
Souad Belkebir ,
Prasad Rajhans ,
Farid Zand ,
Sheila Nainan Myatra ,
Majeda Afeef ,
Vito L. Tanzi  and
S. Muralidharan
...Show all authors
Víctor Daniel Rosenthal*
Affiliation:
International Nosocomial Infection Control Consortium, Buenos Aires, Argentina
Ider Bat-Erdene
Affiliation:
Infection Control Professionals of Mongolia, and Intermed Hospital, Ulaanbaatar, Mongolia
Debkishore Gupta
Affiliation:
BM Birla Heart Research Centre, and The Calcutta Medical Research Institute, Calcutta, India
Souad Belkebir
Affiliation:
An Najah National University Hospital, Nablus, Palestine
Prasad Rajhans
Affiliation:
Deenanath Mangeshkar Hospital, Pune, India
Farid Zand
Affiliation:
Anesthesiology and Critical Care Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
Sheila Nainan Myatra
Affiliation:
Department of Anaesthesiology, Critical Care and Pain, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, India
Majeda Afeef
Affiliation:
King Hussein Cancer Center, Amman, Jordan
Vito L. Tanzi
Affiliation:
Hammoud Hospital University Medical Center, Saida, Lebanon
S. Muralidharan
Affiliation:
G Kuppusamy Naidu Memorial Hospital, Coimbatore, India
Hail M. Al-Abdely
Affiliation:
General Directorate of Infection Prevention and Control, Ministry of Health, Kingdom of Saudi Arabia
Amani El-Kholy
Affiliation:
Dar Al Fouad Hospital, 6th of October City, and Cairo University Hospital, Cairo, Egypt
Safa A. Aziz AlKhawaja
Affiliation:
General Directorate of Infection Prevention and Control, Ministry of Health, Bahrain
Ali Pekcan Demiroz
Affiliation:
Ankara Training and Research Hospital, Ankara, Turkey
Yatin Mehta
Affiliation:
Medanta, The Medicity, New Delhi, India
Vineya Rai
Affiliation:
University Malaya Medical Centre, Kuala Lumpur, Malaysia
Nguyen Viet Hung
Affiliation:
Bach Mai Hospital, Hanoi, Vietnam
Amani F. Sayed
Affiliation:
Farwaniya Hospital, Kuwait City, Kuwait
Estuardo Salgado-Yepez
Affiliation:
Clínica La Merced, Quito, Ecuador
Naheed Elahi
Affiliation:
Dubai Hospital, Dubai, United Arab Emirates
María del Rayo Morfin-Otero
Affiliation:
Hospital Civil de Guadalajara Fray Antonio Alcalde Infection Control Committee, Guadalajara, Mexico
Montri Luxsuwong
Affiliation:
Phyathai 1 Hospital, Pratumthani, Thailand
Braulio Matias De-Carvalho
Affiliation:
Hospital de Messejana, Fortaleza, Brazil
Audrey Rose D. Tapang
Affiliation:
Cardinal Santos Medical Center, San Juan of Philippines, Philippines
Velmira Angelova Velinova
Affiliation:
Queen Giovanna Isul, Sofia, Bulgaria
Ana Marcela Quesada-Mora
Affiliation:
Hospital Clínica Bíblica, San Jose, Costa Rica
Tanja Anguseva
Affiliation:
Special Hospital for Surgical Diseases Filip Vtori, Skopje, Macedonia
Aamer Ikram
Affiliation:
Armed Forces Institute of Pathology, Rawalpindi, Pakistan
Daisy Aguilar-de-Moros
Affiliation:
Hospital del Niño de Panama, Panama City, Panama
Wieslawa Duszynska
Affiliation:
Department of Anesthesiology and Intensive Therapy, Wroclaw Medical University, Wroclaw, Poland
Nepomuceno Mejia
Affiliation:
Hospital General de La Plaza de La Salud, Santo Domingo, Dominican Republic
Florin George Horhat
Affiliation:
University of Medicine and Pharmacy Victor Babes Timisoara Emergency County Clinical Hospital, Timisoara, Romania
Vladislav Belskiy
Affiliation:
Privolzhskiy District Medical Center, Nizhniy Novgorod, Russia
Vesna Mioljevic
Affiliation:
Clinical Center of Serbia, Belgrade, Serbia
Gabriela Di-Silvestre
Affiliation:
Hospital de Clínicas Caracas, Caracas, Venezuela
Katarina Furova
Affiliation:
Catholic University in Ruzomberok Faculty of Health Central Military Hospital Ruzomberok, Ruzomberok, Slovakia
May Osman Gamar-Elanbya
Affiliation:
Royal Care International Hospital, Khartoum, Sudan
Umesh Gupta
Affiliation:
Port Moresby General Hospital, Port Moresby, Papua, New Guinea
Khalid Abidi
Affiliation:
Ibn Sina Hospital of Morocco, Rabat, Morocco
Lul Raka
Affiliation:
National Institute for Public Health of Kosovo and Medical School, Prishtina University, and University Clinical Center of Kosovo, Prishtina, Kosovo
Xiuqin Guo
Affiliation:
Dong E Peoples Hospital, Shandong, People’s Republic of China
Kushlani Jayatilleke
Affiliation:
Sri Jayewardenepura General Hospital, Nugegoda, Sri Lanka
Najla Ben-Jaballah
Affiliation:
Children Hospital Bechir Hamza of Tunis, Tunis, Tunisia
Harrison Ronald Sandoval-Castillo
Affiliation:
Clínica Ricardo Palma, Lima, Peru
Andrew Trotter
Affiliation:
Grande International Hospital, Kathmandu, Nepal
Sandra L. Valderrama-Beltrán
Affiliation:
Pontificia Universidad Javeriana Hospital Universitario San Ignacio, Bogotá, Colombia
Hakan Leblebicioglu
Affiliation:
Ondokuz Mayis University Medical School, Samsun, Turkey
Humberto Guanche-Garcell
Affiliation:
Joaquin Albarran, Havana, Cuba
Miriam de Lourdes-Dueñas
Affiliation:
Hospital Nacional de Niños Benjamin Bloom, San Salvador, El Salvador
*
Author for correspondence: Victor D. Rosenthal, MD, MSc, CIC, E-mail: [email protected].
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Abstract

Background:

Short-term peripheral venous catheter–related bloodstream infection (PVCR-BSI) rates have not been systematically studied in resource-limited countries, and data on their incidence by number of device days are not available.

Methods:

Prospective, surveillance study on PVCR-BSI conducted from September 1, 2013, to May 31, 2019, in 727 intensive care units (ICUs), by members of the International Nosocomial Infection Control Consortium (INICC), from 268 hospitals in 141 cities of 42 countries of Africa, the Americas, Eastern Mediterranean, Europe, South East Asia, and Western Pacific regions. For this research, we applied definition and criteria of the CDC NHSN, methodology of the INICC, and software named INICC Surveillance Online System.

Results:

We followed 149,609 ICU patients for 731,135 bed days and 743,508 short-term peripheral venous catheter (PVC) days. We identified 1,789 PVCR-BSIs for an overall rate of 2.41 per 1,000 PVC days. Mortality in patients with PVC but without PVCR-BSI was 6.67%, and mortality was 18% in patients with PVC and PVCR-BSI. The length of stay of patients with PVC but without PVCR-BSI was 4.83 days, and the length of stay was 9.85 days in patients with PVC and PVCR-BSI. Among these infections, the microorganism profile showed 58% gram-negative bacteria: Escherichia coli (16%), Klebsiella spp (11%), Pseudomonas aeruginosa (6%), Enterobacter spp (4%), and others (20%) including Serratia marcescens. Staphylococcus aureus were the predominant gram-positive bacteria (12%).

Conclusions:

PVCR-BSI rates in INICC ICUs were much higher than rates published from industrialized countries. Infection prevention programs must be implemented to reduce the incidence of PVCR-BSIs in resource-limited countries.

Type
Original Article
Information
Infection Control & Hospital Epidemiology , Volume 41 , Issue 5 , May 2020 , pp. 553 - 563
Copyright
© 2020 by The Society for Healthcare Epidemiology of America. All rights reserved

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Footnotes

a

For a list of the remaining coauthors of this study, see the Appendix.

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