Hostname: page-component-586b7cd67f-rdxmf Total loading time: 0 Render date: 2024-11-24T18:03:08.588Z Has data issue: false hasContentIssue false
  • English
  • Français

Pandemic 2009 Influenza A (H1N1) Virus among Japanese Healthcare Workers: Seroprevalence and Risk Factors

Published online by Cambridge University Press:  02 January 2015

Yoko Nukui ,
Shuji Hatakeyama ,
Takatoshi Kitazawa ,
Tamami Mahira ,
Yoshizumi Shintani  and
Kyoji Moriya
Yoko Nukui
Affiliation:
Department of Infection Control and Prevention, University of Tokyo Hospital, Tokyo, Japan
Shuji Hatakeyama
Affiliation:
Department of Infectious Diseases, University of Tokyo Hospital, Tokyo, Japan
Takatoshi Kitazawa
Affiliation:
Department of Infection Control and Prevention, University of Tokyo Hospital, Tokyo, Japan
Tamami Mahira
Affiliation:
Department of Nursing, University of Tokyo Hospital, Tokyo, Japan
Yoshizumi Shintani
Affiliation:
Department of Infection Control and Prevention, University of Tokyo Hospital, Tokyo, Japan
Kyoji Moriya*
Affiliation:
Department of Infection Control and Prevention, University of Tokyo Hospital, Tokyo, Japan
*
Department of Infection Control and Prevention, 7–3–1 Hongo, Bunkyo-ku, Tokyo 113–8655, Japan ([email protected])
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective.

To evaluate the seroprevalence and risk factors for 2009 influenza A (H1N1) virus infection among healthcare personnel.

Design.

Observational cross-sectional study.

Patients and Setting.

Healthcare workers (HCWs) in an acute care hospital.

Methods.

Between September 14 and October 4, 2009, before 2009 H1N1 vaccination, we collected serological samples from 461 healthy HCWs. Hemagglutination-inhibition antibody assays were conducted. To evaluate the risk factors of seropositivity for 2009 H1N1 virus, gender, age, profession, work department, usage of personal protective equipment, and seasonal influenza vaccination status data were gathered via questionnaires.

Results.

Our survey showed that doctors and nurses were at highest risk of seropositivity for the 2009 H1N1 virus (odds ratio [OR], 5.25 [95% confidence interval {CI}, 1.21–22.7]). An increased risk of seropositivity was observed among pediatric, emergency room, and internal medicine staff (adjusted OR, 1.98 [95% CI, 1.07–3.65]). Risk was also higher among HCWs who had high titers of antibodies against the seasonal H1N1 virus (adjusted OR, 1.59 [95% CI, 1.02–2.48]).

Conclusions.

Seropositivity for the 2009 H1N1 virus was associated with occupational risk factors among HCWs.

Infect Control Hosp Epidemiol 2012;33(1):58-62

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 33 , Issue 1 , January 2012 , pp. 58 - 62
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2012

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Jain, R, Goldman, RD. Novel influenza A (H1N1): clinical presentation, diagnosis, and management. Pediatr Emerg Care 2009;25:791–796.Google Scholar
2. Chan, PK. Lancet conference: influenza in the Asia-Pacific and the international scientific symposium on influenza pandemic response and preparedness. Expert Rev Anti Infect Ther 2009;7:1165–1166.Google Scholar
3. Wada, K, Nishiura, H, Kawana, A. An epidemiological analysis of severe cases of the influenza A (H1N1) 2009 virus infection in Japan. Influ Other Resp Viruses 2010;4:179–186.Google Scholar
4. Bernard, H, Fischer, R, Mikolajczyk, RT, Kretzschmar, M, Wildner, M. Nurses' contacts and potential for infectious disease transmission. Emerg Infect Dis 2009;15:1438–1444.Google Scholar
5. Novel influenza A (H1N1) virus infections among healthcare personnel: United States, April-May 2009. MMWR Morb Mortal Wkly Rep 2009;58:641–645.Google Scholar
6. Melzl, H, Wenzel, JJ, Kochanowski, B, et al. First sequence-confirmed case of infection with the new influenza A (H1N1) strain in Germany. Eurosurveillance 2009;14:19203.Google Scholar
7. Jackson, C, Vynnucky, E, Mangtani, P. Estimates of the transmissibility of the 1968 (Hong Kong) influenza pandemic: evidence of increased transmissibility between successive waves. Am J Epidemiol 2010;171:465–478.Google Scholar
8. Carrat, F, Vergu, E, Ferguson, NM, et al. Time lines of infection and disease in human influenza: a review of volunteer challenge studies. Am J Epidemiol 2008;167:775–785.Google Scholar
9. Zhou, Y, Ng, DMW, Seto, WH, et al. Seroprevalence of antibody to pandemic influenza A (H1N1) 2009 among healthcare workers after the first wave in Hong Kong. J Hosp Infect 78:308–311.Google Scholar
10. Lau, LL, Cowling, BJ, Fang, VJ, et al. Viral shedding and clinical illness in naturally acquired influenza virus infections. J Infect Dis 2010;201:1509–1516.Google Scholar
11. Lemaitre, M, Leruez-Ville, M, Lamballerie, XN, et al. Seasonal H1N1 2007 influenza virus infection is associated with elevated pre-exposure antibody titers to the 2009 pandemic influenza A(H1N1) virus. Clin Microbiol Infect 2011;17:732–737.Google Scholar
12. Tu, W, Mao, H, Zheng, J, et al. Cytotoxic T lymphocytes established by seasonal human influenza cross-react against 2009 pandemic H1N1 influenza virus. J Virol 2010;84:6527–6535.Google Scholar
13. Gilbert, G, Cretikos, MA, Hueston, L, et al. Influenza A (H1N1) 2009 antibodies in residents of New South Wales, Australia, after the first pandemic wave in the 2009 Southern Hemisphere winter. PLoS One 2010;5:e12562.Google Scholar
14. Skowronski, DM, De Serres, G, Crowcroft, NS, et al. Association between the 2008–09 seasonal influenza vaccine and pandemic H1N1 illness during spring-summer 2009: four observational studies from Canada. PLoS Med 2010;7:e1000258.Google Scholar
15. Cheng, VC, Tai, JW, Wong, LM, et al. Prevention of nosocomial transmission of swine-origin pandemic influenza A/H1N1 by infection control bundle. J Hosp Infect 2010;74:271–277.Google Scholar