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Outbreak of Acinetobacter baumannii Bacteremia Related to Contaminated Morphine Used for Patient-Controlled Analgesia

Published online by Cambridge University Press:  02 January 2015

Hsin-Chun Lee ,
Nan-Yao Lee ,
Chia-Ming Chang ,
Cheng-Yang Chou ,
Yi-Hui Wu ,
Li-Rong Wang ,
Nai-Ying Ko ,
Ching-Chuan Liu  and
Wen-Chien Ko
Hsin-Chun Lee
Affiliation:
Departments of Medicine, National Cheng Kung University, Tainan, Taiwan Center of Infection Control, National Cheng Kung University, Tainan, Taiwan
Nan-Yao Lee
Affiliation:
Center of Infection Control, National Cheng Kung University, Tainan, Taiwan National Cheng Kung University Hospital, and theCollege of Medicine, Department of Internal Medicine, National Cheng Kung University, Tainan, Taiwan
Chia-Ming Chang
Affiliation:
Center of Infection Control, National Cheng Kung University, Tainan, Taiwan National Cheng Kung University Hospital, and theCollege of Medicine, Department of Internal Medicine, National Cheng Kung University, Tainan, Taiwan
Cheng-Yang Chou
Affiliation:
Obstetrics and Gynecology, National Cheng Kung University, Tainan, Taiwan
Li-Rong Wang
Affiliation:
Center of Infection Control, National Cheng Kung University, Tainan, Taiwan
Nai-Ying Ko
Affiliation:
Nursing, National Cheng Kung University, Tainan, Taiwan
Ching-Chuan Liu
Affiliation:
Pediatrics, National Cheng Kung University, Tainan, Taiwan Center of Infection Control, National Cheng Kung University, Tainan, Taiwan
Wen-Chien Ko*
Affiliation:
Departments of Medicine, National Cheng Kung University, Tainan, Taiwan Center of Infection Control, National Cheng Kung University, Tainan, Taiwan National Cheng Kung University Hospital, and theCollege of Medicine, Department of Internal Medicine, National Cheng Kung University, Tainan, Taiwan
*
Department of Internal Medicine, National Cheng Kung University, No. 138, Sheng-Li Road, 70403, Tainan, Taiwan ([email protected])
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Abstract

We investigated a cluster of postoperative febrile episodes and episodes of Acinetobacter baumannii bacteremia in obstetrics and gynecology wards after an electrical blackout and loss of the water supply. The use of patient-controlled analgesia was the only independent risk factor associated with postoperative fever, and A. baumannii isolates recovered from the blood of patients who had received patient-controlled analgesia were genetically related to an isolate recovered from the diluted morphine solution used for this procedure. After inappropriate preparation of the morphine solution was identified and stopped, the outbreak ended.

Type
Concise Communications
Information
Infection Control & Hospital Epidemiology , Volume 28 , Issue 10 , October 2007 , pp. 1213 - 1217
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2007 

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References

1. Fournier, PE, Richet, H. The epidemiology and control of Acinetobacter baumannii in healthcare facilities. Clin Infect Dis 2006;42:692–699.Google Scholar
2. Murray, PR, Baron, EJ, Pfaller, MA, et al. Manual of Clinical Microbiology. 7th ed. Washington, DC: ASM Press;1999.Google Scholar
3. National Committee for Clinical Laboratory Standards (NCCLS). Performance Standards for Antimicrobial Susceptibility Testing: 11th Informational Supplement. Villanova, PA: NCCLS;1999:M100-S11.Google Scholar
4. Tenover, FC, Arbeit, RD, Goering, RV, et al. Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J Clin Microbiol 1995;33:2233–2239.Google Scholar
5. Siegman-Igra, Y, Jacobi, E, Lang, R, Schwartz, D, Carmeli, Y. Unexpected hospital-acquired bacteraemia in patients at low risk of bloodstream infection: the role of a heparin drip. J Hosp Infect 2005;60:122–128.Google Scholar
6. Grohskopf, LA, Roth, VR, Feikin, DR, et al. Serratia liquefaciens bloodstream infections from contamination of epoetin alfa at a hemodialysis center. N Engl J Med 2001;344:1491–1497.Google Scholar
7. Goetz, AM, Rihs, JD, Chow, JW, Singh, N, Müder, RR. An outbreak of infusion-related Klebsiella pneumoniae bacteremia in a liver transplantation unit. Clin Infect Dis 1995;21:1501–1503.Google Scholar
8. Ostrowsky, BE, Whitener, C, Bredenberg, HK, et al. Serratia marcescens bacteremia traced to an infused narcotic. N Engl J Med 2002;346:1529–1537.Google Scholar
9. Bennett, SN, McNeil, MM, Bland, LA, et al. Postoperative infections traced to contamination of an intravenous anesthetic, propofol. N Engl J Med 1995;333:147–154.Google Scholar
10. Kastango, ES. Blueprint for implementing USP chapter 797 for compounding sterile preparations. Am J Health Syst Pharm 2005;62:1271–1288.Google Scholar