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Large Outbreak of Infection and Colonization with Gram-Negative Pathogens Carrying the Metallo-β-Lactamase Gene blaIMP-4 at a 320-Bed Tertiary Hospital in Australia

Published online by Cambridge University Press:  02 January 2015

Sophie Herbert
Affiliation:
Infectious Diseases and Microbiology Department, The Alfred Hospital, Melbourne, Victoria, Australia
Dag S. Halvorsen
Affiliation:
Infectious Diseases and Microbiology Department, The Alfred Hospital, Melbourne, Victoria, Australia
Tim Leong
Affiliation:
Intensive Care Unit, The Alfred Hospital, Melbourne, Victoria, Australia
Clare Franklin
Affiliation:
Infectious Diseases and Microbiology Department, The Alfred Hospital, Melbourne, Victoria, Australia
Glenys Harrington
Affiliation:
Infection Control and Epidemiology Unit, The Alfred Hospital, Melbourne, Victoria, Australia
Denis Spelman*
Affiliation:
Infectious Diseases and Microbiology Department, The Alfred Hospital, Melbourne, Victoria, Australia
*
Infectious Diseases and Microbiology Department, The Alfred Hospital, Commercial Road, Melbourne, Victoria 3004, Australia, ([email protected])

Abstract

A large outbreak of infection and colonization with multiple genera of gram-negative bacilli carrying the metallo-β-lactamase gene blaIMP-4 occurred in a 36-bed intensive care unit at a tertiary hospital in Australia. The organisms emerged rapidly, caused severe infections, and contributed to mortality. Controlling the spread of these organisms remains a challenge for all staff involved.

Type
Original Articles
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2007

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References

1. Walsh, TR, Toleman, MA, Poirel, L, Nordmann, P. Metallo-β-lactamases: the quiet before the storm? Clin Microbiol Rev 2005;18:306325.CrossRefGoogle ScholarPubMed
2. Lee, K, Lee, WG, Uh, Y, et al. VIM- and IMP-type metallo-β-lactamase-producing Pseudomonas spp. and Acinetobacter spp. in Korean hospitals. Emerg Infect Dis 2003;9:868871.CrossRefGoogle ScholarPubMed
3. Nouer, SA, Nucci, M, de-Oliveira, MP, Pellegrino, FLPC, Moreira, BM. Risk factors for acquisition of multidrug-resistant Pseudomonas aeruginosa producing SPM metallo-β-lactamase. Antimicrob Agents Chemother 2005;49:36633667.CrossRefGoogle ScholarPubMed
4. Laupland, KB, Parkins, MD, Church, DL, et al. Population-based epidemiological study of infections caused by carbapenem-resistant Pseudomonas aeruginosa in the Calgary Health Region: importance of the metallo-β-lactamase (MBL)-producing strains. J Infect Dis 2005;192:16061612.CrossRefGoogle ScholarPubMed
5. Lee, K, Lim, YS, Yong, D, Yum, JH, Chong, Y. Evaluation of the Hodge test and the imipenem-EDTA double disk synergy test for differentiating me-tallo-β-lactamase-producing isolates of Pseudomonas spp. and Acinetobacter spp. J Clin Microbiol 2003;41:46234629.CrossRefGoogle ScholarPubMed
6. Hirakata, Y, Izumikawa, K, Yamaguchi, T, et al. Rapid detection and evaluation of clinical characteristics of emerging multiple-drug-resistantgram-negative rods carrying the metallo-β-lactamase gene bla IMP . Antimicrob Agents Chemother 1998;42:20062011.CrossRefGoogle Scholar
7. Peleg, AY, Franklin, C, Bell, JM, Spelman, DW. Dissemination of the metallo-β-lactamase gene bla IMP-4 among gram-negative pathogens in a clinical setting in Australia. Clin Infect Dis 2005;41:15491556.CrossRefGoogle Scholar
8. Hirakata, Y, Yamaguchi, T, Nakano, M, et al. Clinical and bacteriological characteristics of IMP-type metallo-β-lactamase-producing Pseudomonas aeruginosa . Clin Infect Dis 2003;37:2632.CrossRefGoogle ScholarPubMed
9. Paterson, DL. Looking for risk factors for the acquisition of antibiotic resistance: a 21st-century approach. Clin Infect Dis 2002;34:15641567.CrossRefGoogle ScholarPubMed