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Hospital-Onset Clostridium difficile Infection Rates in Persons with Cancer or Hematopoietic Stem Cell Transplant: A C3IC Network Report

Published online by Cambridge University Press:  02 January 2015

Mini Kamboj*
Affiliation:
Memorial Sloan Kettering Cancer Center, New York, New York
Crystal Son
Affiliation:
Memorial Sloan Kettering Cancer Center, New York, New York
Sherry Cantu
Affiliation:
MD Anderson Cancer Center, Houston, Texas
Roy F. Chemaly
Affiliation:
MD Anderson Cancer Center, Houston, Texas
Jeanne Dickman
Affiliation:
James Cancer Hospital at Ohio State University Medical Center, Columbus, Ohio
Erik Dubberke
Affiliation:
Barnes-Jewish Hospital, Siteman Cancer Center, St. Louis, Missouri Washington University School of Medicine, St. Louis, Missouri
Lisa Engles
Affiliation:
Barbara Ann Karmanos Cancer Institute, Detroit, Michigan
Theresa Lafferty
Affiliation:
Fox Chase Cancer Center, Philadelphia, Pennsylvania
Gale Liddell
Affiliation:
Roswell Park Cancer Institute, Buffalo, New York
Mary Ellen Lesperance
Affiliation:
Barbara Ann Karmanos Cancer Institute, Detroit, Michigan
Julie E. Mangino
Affiliation:
James Cancer Hospital at Ohio State University Medical Center, Columbus, Ohio
Stacy Martin
Affiliation:
Moffitt Cancer Center, Tampa, Florida
Jennie Mayfield
Affiliation:
Barnes-Jewish Hospital, Siteman Cancer Center, St. Louis, Missouri
Sapna A. Mehta
Affiliation:
NYU Langone Medical Center, New York, New York
Susan O'Rourke
Affiliation:
Dana-Farber Cancer Institute, Boston, Massachusetts
Cheryl S. Perego
Affiliation:
MD Anderson Cancer Center, Houston, Texas
Randy Taplitz
Affiliation:
Thornton Hospital, UCSD, La Jolla, California
Janet Eagan
Affiliation:
Memorial Sloan Kettering Cancer Center, New York, New York
Kent A. Sepkowitz
Affiliation:
Memorial Sloan Kettering Cancer Center, New York, New York
*
1275 York Avenue, New York, NY 10065 ([email protected])

Abstract

A multicenter survey of 11 cancer centers was performed to determine the rate of hospital-onset Clostridium difficile infection (HO-CDI) and surveillance practices. Pooled rates of HO-CDI in patients with cancer were twice the rates reported for all US patients (15.8 vs 7.4 per 10,000 patient-days). Rates were elevated regardless of diagnostic test used.

Type
Concise Communication
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2012

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References

2.Anand, A, Glatt, AE. Clostridium difficile infection associated with antineoplastic chemotherapy: a review. Clin Infect Dis 1993;17(1):109113.Google Scholar
3.Gorschluter, M, Glasmacher, A, Hahn, C, et al.Clostridium difficile infection in patients with neutropenia. Clin Infect Dis 2001;33(6):786791.CrossRefGoogle ScholarPubMed
4.Loo, VG, Poirier, L, Miller, MA, et al.A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality. N Engl J Med 2005;353(23):24422449.Google Scholar
5.Bobak, D, Arfons, LM, Creger, RJ, Lazarus, HM. Clostridium difficile-associated disease in human stem cell transplant recipients: coming epidemic or false alarm? Bone Marrow Transplantation 2008;42(11):705713.Google Scholar
6.McDonald, LC, Coignard, B, Dubberke, E, et al.Recommendations for surveillance of Clostridium difficile-associated disease. Infect Control Hosp Epidemiol 2007;28(2):140145.Google Scholar
10.Vital signs: preventing Clostridium difficile infections. MMWR Morb Mortal Wkly Rep 2012;61:157162.Google Scholar
11.Deshpande, A, Pasupuleti, V, Rolston, DD, et al.Diagnostic accuracy of real-time polymerase chain reaction in detection of Clostridium difficile in the stool samples of patients with suspected Clostridium difficile infection: a meta-analysis. Clin Infect Dis 2011;53(7):e81e90.Google Scholar
12.Fong, KS, Fatica, C, Hall, G, et al.Impact of PCR testing for Clostridium difficile on incident rates and potential on public reporting: is the playing field level? Infect Control Hosp Epidemiol 2011;32(9):932933.Google Scholar
13.Kaltsas, A, Simon, M, Unruh, LH, et al.Clinical and laboratory characteristics of Clostridium difficile infection in patients with discordant diagnostic test results. J Clinical Microbiol 2012:50(4):13031307.Google Scholar