Hostname: page-component-55f67697df-px5tt Total loading time: 0 Render date: 2025-05-10T03:30:40.394Z Has data issue: false hasContentIssue false
  • English
  • Français

Exeporfinium chloride (XF-73) nasal gel significantly reduces Staphylococcus aureus nasal carriage in cardiac surgery patients throughout surgery and the early recovery period: results from a randomized placebo-controlled Phase 2 study

Published online by Cambridge University Press:  10 October 2024

Julie E. Mangino ,
Michael S. Firstenberg Open the ORCID record for Michael S. Firstenberg [Opens in a new window] ,
William Rhys-Williams Open the ORCID record for William Rhys-Williams [Opens in a new window] ,
James P. Lees ,
Aaron Dane ,
William G. Love ,
Jesus Gonzalez Moreno ,
Yuri Martina  and
Debra Barker Open the ORCID record for Debra Barker [Opens in a new window]
Julie E. Mangino
Affiliation:
Division of Infection Diseases, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA
Michael S. Firstenberg
Affiliation:
Department of Surgery, Maui Memorial Medical Center, Maui, HI, USA
William Rhys-Williams*
Affiliation:
Destiny Pharma plc, Brighton, UK
James P. Lees
Affiliation:
Formerly at Destiny Pharma plc, Brighton, UK
Aaron Dane
Affiliation:
Danestat Consulting Ltd., Macclesfield, UK
William G. Love
Affiliation:
Destiny Pharma plc, Brighton, UK
Jesus Gonzalez Moreno
Affiliation:
Formerly at Destiny Pharma plc, Brighton, UK
Yuri Martina
Affiliation:
Formerly at Destiny Pharma plc, Brighton, UK
Debra Barker
Affiliation:
Destiny Pharma plc, Brighton, UK
*
Corresponding author: William Rhys-Williams; Email: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Staphylococcus aureus nasal carriers were randomized (1:1) to XF-73 or placebo nasal gel, administered 5x over ∼24hrs pre-cardiac surgery. S. aureus burden rapidly decreased after 2 doses (–2.2log10 CFU/mL; placebo –0.01log10 CFU/mL) and was maintained to 6 days post-surgery. Among XF-73 patients, 46.5% received post-operative anti-staphylococcal antibiotics versus 70% in placebo (P = 0.045).

Type
Concise Communication
Information
Infection Control & Hospital Epidemiology , Volume 45 , Issue 11 , November 2024 , pp. 1355 - 1357
Check for updates
Copyright
© Destiny Pharma Limited, 2024. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

Muñoz, P, Hortal, J, Giannella, M, et al. Nasal carriage of Staphylococcus aureus increases the risk of surgical site infection after major heart surgery. J Hosp Infect 2008;68:25–31.CrossRefGoogle ScholarPubMed
Calderwood, MS, Anderson, DJ, Bratzler, DW, et al. Strategies to prevent surgical site infections in acute-care hospitals: 2022 Update. Infect Control Hosp Epidemiol 2023;44(5):695–720.CrossRefGoogle ScholarPubMed
Septimus, EJ. Nasal decolonization: what antimicrobials are most effective prior to surgery? Am J Infect Control 2019;47S:A53–A57.CrossRefGoogle ScholarPubMed
Kluytmans, JA, Wertheim, HF. Nasal carriage of Staphylococcus aureus and prevention of nosocomial infections. Infection 2005;33:3–8.CrossRefGoogle ScholarPubMed
Global Guidelines for the Prevention of Surgical Site Infection, 2nd Edition Geneva: World Health Organization; 2019. https://iris.who.int/bitstream/handle/10665/277399/9789241550475-eng.pdf?sequence=1 Google Scholar
Dadashi, M, Hajikhani, B, Darban-Sarokhalil, D, et al. Mupirocin resistance in Staphylococcus aureus: a systematic review and meta-analysis, J Glob Antimicrob Resist 2020:238–247.CrossRefGoogle ScholarPubMed
Ooi, N, Miller, K, Hobbs, J, et al. XF-73, a novel antistaphylococcal membrane-active agent with rapid bactericidal activity. J Antimicrob Chemother 2009;64:735–40.CrossRefGoogle ScholarPubMed
Farrell, DJ, Robbins, M, Rhys Williams, W, Love, WG. Investigation of the potential for mutational resistance to XF-73, retapamulin, mupirocin, fusidic acid, daptomycin, and vancomycin in methicillin-resistant Staphylococcus aureus isolates during a 55-passage study. Antimicrob Agents Chemother 2011;55:1177–81.CrossRefGoogle ScholarPubMed
Mangino, JE, Firstenberg, MS, Milewski, RKC, et al. Exeporfinium chloride (XF-73) nasal gel dosed over 24 hours prior to surgery significantly reduced Staphylococcus aureus nasal carriage in cardiac surgery patients: safety and efficacy results from a randomized placebo-controlled phase 2 study. Infect Control Hosp Epidemiol 2023:44:1–3 CrossRefGoogle ScholarPubMed
Kanwar, A, Cadnum, JL, Jencson, AL, Donskey, CJ. Impact of antibiotic treatment on the burden of nasal Staphylococcus aureus among hospitalized patients. Antimicrob Agents Chemother 2018;62:e00609–18.CrossRefGoogle ScholarPubMed
Supplementary material: File

Mangino et al. supplementary material

Mangino et al. supplementary material
Download Mangino et al. supplementary material(File)
File 184.4 KB