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Evaluation of H2O2 Prophylaxis of Bacteriuria in Patients with Long-Term Indwelling Foley Catheters: A Randomized Controlled Study

Published online by Cambridge University Press:  02 January 2015

Donna E. Sweet ,
Hewitt C. Goodpasture ,
Katherine Holl ,
Sharon Smart ,
Holly Alexander  and
Ahmad Hedari
Donna E. Sweet*
Affiliation:
Department of Internal Medicine, University of Kansas School of Medicine-Wichita, and the Aseptic Practice, Microbiology, and Biostatistics Departments, Wesley Medical Center, Wichita, Kansas
Hewitt C. Goodpasture
Affiliation:
Department of Internal Medicine, University of Kansas School of Medicine-Wichita, and the Aseptic Practice, Microbiology, and Biostatistics Departments, Wesley Medical Center, Wichita, Kansas
Katherine Holl
Affiliation:
Department of Internal Medicine, University of Kansas School of Medicine-Wichita, and the Aseptic Practice, Microbiology, and Biostatistics Departments, Wesley Medical Center, Wichita, Kansas
Sharon Smart
Affiliation:
Department of Internal Medicine, University of Kansas School of Medicine-Wichita, and the Aseptic Practice, Microbiology, and Biostatistics Departments, Wesley Medical Center, Wichita, Kansas
Holly Alexander
Affiliation:
Department of Internal Medicine, University of Kansas School of Medicine-Wichita, and the Aseptic Practice, Microbiology, and Biostatistics Departments, Wesley Medical Center, Wichita, Kansas
Ahmad Hedari
Affiliation:
Department of Internal Medicine, University of Kansas School of Medicine-Wichita, and the Aseptic Practice, Microbiology, and Biostatistics Departments, Wesley Medical Center, Wichita, Kansas
*
Department of Internal Medicine, University of Kansas School of Medicine-Wichita, 1010 N. Kansas, Wichita, KS 67214
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Abstract

Since the long-term catheterized patient is at significant risk of urinary tract infection, and the catheter drainage bags of these patients are at significant risk of becoming reservoirs for nosocomial pathogens, we carried out a randomized, controlled study to determine the efficacy of intermittent drainage bag instillation of hydrogen peroxide (H2O2) in patients requiring indwelling Foley catheters for 5 days or more. Herein we report the effects of this technique on the rates of catheter and bag bacteriuria, the duration to positive culture, the temporal relationships observed, and the spectrum of organisms recovered. Bag source bacteriuria was found with the same frequency in both control and H2O2 groups. H2O2 did reduce contamination of the drainage bag but did not reduce catheter-associated bacteriuria or frequency of symptomatic urinary tract infection. Furthermore, H2O2 did not reduce the frequency of bag contamination with most of the common nosocomial urinary pathogens.

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 6 , Issue 7 , July 1985 , pp. 263 - 266
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1985

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