Hostname: page-component-586b7cd67f-rcrh6 Total loading time: 0 Render date: 2024-11-28T06:27:56.731Z Has data issue: false hasContentIssue false
  • English
  • Français

The Epidemiology of Cytomegalovirus Infection Among Patients with Burns

Published online by Cambridge University Press:  21 June 2016

James F. Bale Jr. ,
G. Patrick Kealey ,
R. Michael Massanari  and
Ronald G. Strauss
James F. Bale Jr.
Affiliation:
Department of Pediatrics, The University of Iowa College of Medicine, Iowa City, Iowa
G. Patrick Kealey*
Affiliation:
Department of Surgery, The University of Iowa College of Medicine, Iowa City, Iowa
R. Michael Massanari
Affiliation:
Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa
Ronald G. Strauss
Affiliation:
Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa
*
Department of Surgery, The University of Iowa College of Medicine, Iowa City, IA 52242
Get access Rights & Permissions [Opens in a new window]

Abstract

To determine the epidemiology of cytomegalovirus (CMV) infections among patients with burns, we prospectively studied 120 burn patients admitted to the University of Iowa Burn Center over a two-and-one-half year period. At the time of their admission, 44% of the patients had serologic evidence of prior CMV infection. Among 44 seropositive patients, 23 (52%) had four-fold or greater rises in CMV antibody titers. These patients had more severe burns (mean body surface area burn [BSAB] 26.8%) than those who did not exhibit titer rises (mean BSAB 16.2%, p=.04). Among 43 seronegative patients observed for at least 65 days after discharge from the center, eight (18.6%) seroconverted. Patients who seroconverted had longer hospital stays (p=.03), trends toward more severe burns p = .08) and a younger age (p = .15) than patients who remained seronegative. Despite frequent serologic evidence of CMV infection, CMV did not contribute, either directly or indirectly, to the morbidity or mortality of burns in these patients.

Type
Original articles
Information
Infection Control & Hospital Epidemiology , Volume 11 , Issue 1 , January 1990 , pp. 17 - 22
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1990

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Seeman, J, Konigova, R. Cytomegalovirus infection in severely burned patients. Acta Chir Plast. 1976;18:142–151.Google ScholarPubMed
2. Deepe, GS, MacMillan, BG, Linnemann, CC. Unexplained fever in burn patients due to cytomegalovirus infection. JAMA. 1982;248:2299–2301.10.1001/jama.1982.03330180059034CrossRefGoogle ScholarPubMed
3. Linnemann, CC, MacMillan, BG. Viral infections in pediatric burn patients. AJDC. 1981;135:750–753.Google ScholarPubMed
4. Kagan, RJ, Naraqi, S, Matsuda, T, Jonasson, OM. Herpes simplex virus and cytomegalovirus infections in burned patients. J Trauma. 1985:25:40–45.10.1097/00005373-198501000-00007CrossRefGoogle ScholarPubMed
5. Kealey, GP, Bale, JF, Strauss, RG, Massanari, RM. Cytomegalovirus infection in burn patients. JBCR. 1987;8:543–545.Google ScholarPubMed
6. The American Burn Association. Protocols for burns and transfer agreement. 1967.Google Scholar
7. McHugh, TM, Casavant, CH, Wilber, JC, Stites, DP. Comparison of six methods for the detection of antibody to cytomegalovirus. J Clin Microbiol. 1985;6:1014–1019.10.1128/jcm.22.6.1014-1019.1985CrossRefGoogle Scholar
8. Gleaves, CA, Smith, TF, Shuster, EA, Pearson, GR. Rapid detection of cytomegalovirus in MRC-5 cells inoculated with urine specimens by using low-speed centrifugation and monoclonal antibody to an early antigen. J Clin Microbiol. 1984;19:917–919.10.1128/jcm.19.6.917-919.1984CrossRefGoogle Scholar
9. Pass, RF, August, DM, Dworsky, M, Reynolds, DW. Cytomegalovirus infection in a day care center. N Engl J Med. 1982;307:477–479.10.1056/NEJM198208193070804CrossRefGoogle Scholar
10. Murph, JR, Bale, JF The natural history of acquired cytomegalovirus infection among children in group day care. AJDC. 1988;142:843–846.Google ScholarPubMed
11. Adler, SP. Transfusion-associated cytomegalovirus infection. J Infect Dis. 1983;6:977–993.Google Scholar
12. Tegtmeier, GE. Transfusion-transmitted cytomegalovirus infections: significance and control. Vox Sang. 1986;51:22–30.10.1111/j.1423-0410.1986.tb01990.xCrossRefGoogle ScholarPubMed
13. Preiksaitis, JK, Brown, L, McKenzie, M. The risk of cytomegalovirus infection in seronegative transfusion recipients not receiving exogenous immunosuppression. J Infect Dis. 1988; X6523–529.Google Scholar
14. Shelby, J Shanley, J, Transfer of murine cytomegalovirus by syngeneic skin grafts. Transplantation. 1987;44:318–320.Google ScholarPubMed
15. Rand, KH, Pollard, RB, Merigan, TC. Increased pulmonary superinfections in cardiac transplant patients undergoing primary cytomegalovirus infection. N Engl J Med. 1978;298:951–953.10.1056/NEJM197804272981705CrossRefGoogle ScholarPubMed
16. Kumar, ML, Jensorv, HB, Dahms, BB. Fatal Staphylococcal epidermidis infections in very low-birth-weight infants with cytomegalovirus infection. Pediatrics. 1985;76:110–112.Google ScholarPubMed
17. Hamilton, JR, Overall, JC, Glasgow, LA. Synergistic effect on mortality in mice with murine cytomegalovirus and Pseudomonas aeruginosa, Staphylococcus aureus, or Candida albicans infections. Infect Immun. 1976;14:982–989.10.1128/iai.14.4.982-989.1976CrossRefGoogle ScholarPubMed
18. Bale, JF, Kern, ER, Overall, JC, Glasaow, LA. Enhanced susceDtibility of mice infected with murine cytomegalovirus to intranasal challenge with Escherichia coli: pathogenesis and altered inflammatory response. J Infect Dis. 1982;145:525–531.10.1093/infdis/145.4.525CrossRefGoogle ScholarPubMed
19. Nash, G, Asch, MJ, Foley, FD, Pruitt, BA. Disseminated cytomegalic inclusion disease in a burned adult. JAMA. 1970;214:587–589.10.1001/jama.1970.03180030103027CrossRefGoogle Scholar
20. Persaud, V, Two unusual cases of mural endocarditis, with a review of the literature. Amer J Clin Path. 1970;53:832–838.10.1093/ajcp/53.6.832CrossRefGoogle ScholarPubMed
21. Moran, KT, Thupari, JN, O'Reilly, TJ, Munster, AM. Effect of immunoglobulin G therapy on serum antibody titers to cytomegalovirus in burn patients. Am J Surg. 1988;155:294–297.10.1016/S0002-9610(88)80718-9CrossRefGoogle ScholarPubMed