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The epidemiology of carbapenem resistant Enterobacter spp: A case–case–control matched analysis

Published online by Cambridge University Press:  24 November 2020

Leore Cohen Mendel
Affiliation:
Unit of Infection Control, Shamir (Assaf Harofeh) Medical Center, Zerifin, Israel
Keren Amity
Affiliation:
Unit of Infection Control, Shamir (Assaf Harofeh) Medical Center, Zerifin, Israel
David E. Katz
Affiliation:
Division of Internal Medicine, Shaare Zedek Medical Center, the Hebrew University Hadassah Medical School, Jerusalem, Israel
Tsilia Lazarovitch
Affiliation:
The Microbiology Laboratory, Shamir (Assaf Harofeh) Medical Center, Zerifin, Israel
Ronit Zaidenstein
Affiliation:
Department of Medicine A, Shamir (Assaf Harofeh) Medical Center, Zerifin, Israel Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel
Dror Marchaim*
Affiliation:
Unit of Infection Control, Shamir (Assaf Harofeh) Medical Center, Zerifin, Israel Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel
*
Author for correspondence: Dror Marchaim, MD, E-mail: [email protected]

Abstract

A case–case–control investigation (216 patients) examined the risk factors and outcomes of carbapenem-resistant Enterobacter (CR-En) acquisition. Recent exposure to fluoroquinolones, intensive care unit (ICU) stay, and rapidly fatal McCabe condition were independent predictors for acquisition. Acquiring CR-En was independently associated with discharge to a long-term care facility after being admitted from home.

Type
Concise Communication
Copyright
© The Author(s), 2020. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America

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Footnotes

PREVIOUS PRESENTATION: Some of the information pertaining to patients with CR-En which was included in this publication, was also retrieved for a study previously published as Lazarovitch T, Amity K, Coyle JR, et al. The complex epidemiology of carbapenem-resistant enterobacter infections: a multicenter descriptive analysis. Infect Control Hosp Epidemiol 2015;36:1283–1291.

References

Lazarovitch, T, Amity, K, Coyle, JR, et al. The complex epidemiology of carbapenem-resistant enterobacter infections: a multicenter descriptive analysis. Infect Control Hosp Epidemiol 2015;36:12831291.CrossRefGoogle ScholarPubMed
WHO publishes list of bacteria for which new antibiotics are urgently needed. World Health Organization website. http://www.who.int/mediacentre/news/releases/2017/bacteria-antibiotics-needed/en/. Published April 14, 2017. Accessed October 1, 2020.Google Scholar
Marchaim, D, Chopra, T, Perez, F, et al. Outcomes and genetic relatedness of carbapenem-resistant Enterobacteriaceae at Detroit medical center. Infect Control Hosp Epidemiol 2011;32:861–71.CrossRefGoogle ScholarPubMed
Leclercq, R, Cantón, R, Brown, DFJ, et al. EUCAST expert rules in antimicrobial susceptibility testing. Clin Microbiol Infect 2013;19:141–60.CrossRefGoogle ScholarPubMed
Kaye, KS, Harris, AD, Samore, M, Carmeli, Y. The case–case–control study design: addressing the limitations of risk factor studies for antimicrobial resistance. Infect Control Hosp Epidemiol 2005;26:346351.CrossRefGoogle ScholarPubMed
Types of healthcare-associated infections. Centers for Disease Control and Prevention website. https://www.cdc.gov/hai/infectiontypes.html. Updated March 2014. Accessed October 29, 2020.Google Scholar
Charlson, ME, Pompei, P, Ales, KL, et al. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 1987;40:373383.CrossRefGoogle ScholarPubMed
Bion, JF, Edlin, SA, Ramsay, G, et al. Validation of a prognostic score in critically ill patients undergoing transport. Br Med J (Clin Res Ed) 1985;291:432434.CrossRefGoogle ScholarPubMed
Katz, S, Ford, AB, Moskowitz, RW, Jackson, BA, Jaffe, MW. Studies of illness in the aged. The index of ADL: a standardized measure of biological and psychosocial function. JAMA 1963;185:914919.CrossRefGoogle ScholarPubMed
Fuzi, M, Rodriguez Baño, J, Toth, A. Global evolution of pathogenic bacteria with extensive use of fluoroquinolone agents. Front Microbiol 2020;11:271.CrossRefGoogle ScholarPubMed