Hostname: page-component-78c5997874-mlc7c Total loading time: 0 Render date: 2024-11-02T21:05:35.807Z Has data issue: false hasContentIssue false

Effectiveness of Gentamicin-Impregnated Cement in the Prevention of Deep Wound Infection After Primary Total Knee Arthroplasty

Published online by Cambridge University Press:  02 January 2015

Matthieu Eveillard*
Affiliation:
Department of Bacteriology and Infection Control, Centre Hospitalier Universitaire d'Amiens, Amiens, France
Patrice Mertl
Affiliation:
Department of Orthopaedic Surgery and Traumatology, Centre Hospitalier Universitaire d'Amiens, Amiens, France
Blaise Tramier
Affiliation:
Department of Statistics and Epidemiology, Centre Hospitalier Universitaire d'Amiens, Amiens, France
François Eb
Affiliation:
Department of Bacteriology and Infection Control, Centre Hospitalier Universitaire d'Amiens, Amiens, France
*
Laboratoire de Microbiologie et Hygiène, Hôpital Louis Mourier, 178 rue des renouillers, F92700 Colombes, France

Abstract

Effectiveness of gentamicin-impregnated cement in preventing deep wound infection after total knee arthroplasty (TKA) was estimated using data from prospective surveillance. In multivariate analysis, the protective effect of gentamicin-impregnated cement on the development of infection was close to the limit of significance. Gentamicin-impregnated cement may prevent TKA infections.

Type
Concise Communications
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2003

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Wade, M, Baba, H, Imura, S. Prosthetic knee Candida parapsilosis infection. J Arthroplasty 1998;13:479482.Google Scholar
2.Segawa, H, Tsukayama, DT, Kyle, RF, Becker, DA, Gustilo, RP. Infection after total knee arthroplasty. J Bone Joint Surg Am 1999;81:14341445.Google Scholar
3.Association of Operating Room Nurses. Recommended practices for skin preparation of patients. AORN J 1996;64:813816.Google Scholar
4.Hill, C, Flamant, R, Mazas, F, Evrard, J. Prophylactic cefazolin vs. placebo in total hip replacement. Lancet 1981;1:795796.Google Scholar
5.Iidwell, OM, Lowbury, RJL, Whyte, W, Blowers R Stanley, SJ, Lowe, D. Effect of ultraclean air in operating rooms on deep sepsis in the joint after total hip or knee replacement a randomized study. Br Med J 1982;285:1014.Google Scholar
6.Schutzer, SF, Harris, WH. Deep wound infection after total hip replacement under contemporary aseptic conditions. J Bone Joint Surg Am 1988;70:724727.Google Scholar
7.Persson, U, Persson, M, Malchan, H. The economics of preventing revisions in total hip replacement. Acta Orthop Scand 1999;70:163169.Google Scholar
8.Chiu, FY, Chen, CM, Lin, CF, Lo, WH. Cefuroxime-impregnated cement in primary total knee arthroplasty: a prospective randomized study of three hundred and forty knees. J Bone Joint Surg Am 2002;84:759762.Google Scholar
9.Hanssen, AD, Osmon, DRThe use of prophylactic antimicrobial agents during and after hip arthroplasty. Clin Orthop 1999;369:124138.Google Scholar
10.Société Française d'Anesthésie et de Réanimation. Antibioprophylaxie en milieu chirurgical chez l'adulte: conférence de consensus. Ann Fr Anesth Reanim 1992;12:337354.Google Scholar
11.Société Française d'Anesthésie et de Réanimation. Recommandations pour la pratique de l'antibioprophylaxie en chirurgie: actualisation 1999. Médecine Maladies Infectieuses 1999;29:435445.Google Scholar
12.Greenfield, S. The state of outcome research: are we on target? N Engl J Med 1989;320:11421143.Google Scholar
13.Chiu, FY, Lin, CF, Chen, CM, Lo, WH, Chaung, TY. Cefuroxime-impregnated cement at primary total knee arthroplasty in diabetes mellitus: a prospective, randomised study. J Bone Joint Surg Br 2001;83:691695.Google Scholar
14.Lelièvre, H, Lina, G, Jones, ME, et al.Emergence and spread in French hospitals of methicillin-resistant Staphylococcus aureus with increasing susceptibility to gentamicin and other antibiotics. J Clin Microbiol 1999;37:34523457.Google Scholar