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Effect of Intranasal Mupirocin Prophylaxis on Methicillin-Resistant Staphylococcus aureus Transmission and Invasive Staphylococcal Infections in a Neonatal Intensive Care Unit

Published online by Cambridge University Press:  02 April 2018

Elizabeth H. Ristagno ,
Kristina A. Bryant ,
Lynette F. Boland ,
Gordon G. Stout ,
Alan D. Junkins ,
Charles R. Woods ,
John A. Myers  and
Claudia M. Espinosa
Elizabeth H. Ristagno
Affiliation:
Division of Pediatric Infectious Diseases, Mayo Clinic, Rochester, Minnesota
Kristina A. Bryant
Affiliation:
Department of Pediatrics, University of Louisville, Louisville, Kentucky
Lynette F. Boland
Affiliation:
Norton Children’s Hospital, Louisville, Kentucky
Gordon G. Stout
Affiliation:
Department of Pediatrics, University of Louisville, Louisville, Kentucky
Alan D. Junkins
Affiliation:
Norton Healthcare, Louisville, Kentucky
Charles R. Woods
Affiliation:
Department of Pediatrics, University of Louisville, Louisville, Kentucky
John A. Myers
Affiliation:
Department of Pediatrics, University of Louisville, Louisville, Kentucky
Claudia M. Espinosa*
Affiliation:
Department of Pediatrics, University of Louisville, Louisville, Kentucky
*
Address correspondence to Claudia M. Espinosa, MD, Department of Pediatrics, University of Louisville, 571 S Floyd St Suite 321, Louisville, Kentucky ([email protected]).
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Abstract

The use of monthly intranasal mupirocin was associated with a significant reduction in the rate of methicillin-resistant Staphylococcus aureus transmission and Staphylococcus aureus invasive infection in a large neonatal intensive care unit. Resistance to mupirocin emerged over time, but it was rare and was not associated with adverse clinical outcomes.

Infect Control Hosp Epidemiol 2018;39:741–745

Type
Concise Communications
Information
Infection Control & Hospital Epidemiology , Volume 39 , Issue 6 , June 2018 , pp. 741 - 745
Copyright
© 2018 by The Society for Healthcare Epidemiology of America. All rights reserved 

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Footnotes

PREVIOUS PRESENTATION. Findings presented at the Infectious Diseases Society of America’s IDWeek on October 10, 2015, in San Diego, California, and at the Society for Healthcare Epidemiology of America (SHEA) meeting on May 20, 2016, in Atlanta, Georgia.

References

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