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Clinical Pharmacology of Antibiotics: Do Antibiotics Interfere with Host/Bacterial Interaction?

Published online by Cambridge University Press:  02 January 2015

Atef M. Shibl
Atef M. Shibl*
Affiliation:
University of California Medical School, San Francisco General Hospital, San Francisco, California
*
The Medical Service, Room 5 H 22, San Francisco General Hospital, San Francisco, CA 94110
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Extract

Antibiotics exert a number of effects on bacteria other than simply killing them or inhibiting their growth. Increasing evidence that exposure of bacteria to antibiotics induces profound alterations in the interaction between bacteria and host defense has been noted. The effect of antibiotics on polymorphonuclear leukocytes and the immune specific response of mononuclear cells is reviewed. An understanding of such effects would allow a more rational application of antibiotics, as well as provide direction in the development of new antibiotics that have both specific antibacterial action and positive effects on host defense mechanisms.

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 6 , Issue 8 , August 1985 , pp. 326 - 328
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1985

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