Hostname: page-component-586b7cd67f-rcrh6 Total loading time: 0 Render date: 2024-11-28T10:51:02.861Z Has data issue: false hasContentIssue false

Clinical impact of matrix-assisted laser desorption ionization time-of-flight mass spectrometry for the management of inpatient pneumonia without additional antimicrobial stewardship support

Published online by Cambridge University Press:  12 July 2019

Ann Marie Porreca Kratz*
Affiliation:
Department of Pharmacy, St Luke’s University Hospital, Bethlehem, Pennsylvania
Kaede V. Sullivan
Affiliation:
Department of Pathology and Laboratory Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania
Jason C. Gallagher
Affiliation:
Temple University School of Pharmacy, Philadelphia, Pennsylvania
*
Author for correspondence: Ann Marie Porreca Kratz, 801 Ostrum Street, Bethlehem, PA 18015, E-mail: [email protected]

Abstract

We assessed whether implementation of matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry without antimicrobial stewardship support would impact antimicrobial utilization and clinical outcomes in inpatient pneumonia. Implementation significantly reduced time to organism identification and time to optimal therapy but did not have a detectable impact on clinical outcomes.

Type
Concise Communication
Copyright
© 2019 by The Society for Healthcare Epidemiology of America. All rights reserved. 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Dellit, T, Owens, R, McGowan, J, et al. Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America guidelines for developing an institutional program for enhancing antimicrobial stewardship. Clin Infect Dis 2007;44:159177.Google Scholar
Huang, AM, Newtown, D, Kunapuli, A, et al. Impact of rapid organism identification via matrix-assisted laser desorption/ionization time-of-flight combined with antimicrobial stewardship team intervention in adult patients with bacteremia and candidemia. Clin Infect Dis 2013;57:12371245.CrossRefGoogle ScholarPubMed
Nagel, JL, Huang, AM, Kunapuli, A, et al. Impact of antimicrobial stewardship intervention on coagulase-negative Staphylococcus blood cultures in conjunction with rapid diagnostic testing. J Clin Microbiol 2014;52:28492854.Google ScholarPubMed
Clerc, O, Pro’hom, G, Vogne, C, Bizzini, A, Calandra, T, Greub, G. Impact of matrix-assisted laser desorption ionization time-of-flight mass spectrometry on the clinical management of patients with gram-negative bacteremia: a prospective observational study. Clin Infect Dis 2013;56:11011107.Google ScholarPubMed
Vlek, AL, Bonten, MJ, Boel, CH. Direct matrix-assisted laser desorption ionization time-of-flight mass spectrometry improves appropriateness of antibiotic treatment of bacteremia. PLoS One 2012;7(3):e32589.CrossRefGoogle ScholarPubMed
Holtzman, C, Whitney, D, Barlam, T, Miller, NS. Assessment of impact of peptide nucleic acid flurorescence in situ hybridization for rapid identification of coagulase-negative Staphylococcus in absence of antimicrobial stewardship intervention. J Clin Microbiol 2011;49:15811582.CrossRefGoogle Scholar
Beganovic, M, Costello, M, Wieczorkiewicz, SM. MALDI-TOF alone versus MALDI-TOF combined with real-time antimicrobial stewardship interventions on time to optimal antimicrobial therapy in patients with positive blood cultures. J Clin Microbiol 2017; 55. doi: 10.1128/JCM.02245-16.CrossRefGoogle ScholarPubMed
Clinical and Laboratory Standards Institute. Performance Standards for Antimicrobial Susceptibility Testing, 28th ed. CLSI M100 Supplement. Wayne, PA: CLSI.Google Scholar
Wenzler, E, Goff, DA, Mangino, JE, Reed, EE, Wehr, A, Bauer, KA. Impact of rapid identification of Acinetobacter baumannii via matrix-assisted laser desorption ionization time-of-flight mass spectrometry combined with antimicrobial stewardship in patients with pneumonia and/or bacteremia. Diagn Microbiol Infect Dis 2016;84:6368.CrossRefGoogle ScholarPubMed
Mok, JH, Eom, JS, Jo, EJ, et al. Clinical utility of rapid pathogen identification using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry in ventilated patients with pneumonia: a pilot study. Respirology 2016;21:321328.CrossRefGoogle ScholarPubMed