Hostname: page-component-586b7cd67f-rdxmf Total loading time: 0 Render date: 2024-11-24T09:56:27.988Z Has data issue: false hasContentIssue false
  • English
  • Français

Capabilities of global high-level isolation units: A pre-workshop survey

Published online by Cambridge University Press:  01 December 2021

Jocelyn J. Herstein Open the ORCID record for Jocelyn J. Herstein [Opens in a new window] ,
Timo Wolf ,
Emanuele Nicastri Open the ORCID record for Emanuele Nicastri [Opens in a new window] ,
Yee Sin Leo ,
Poh Lian Lim ,
Michael Jacobs ,
Sharon Vanairsdale ,
Eric Toner ,
Matthew P. Shearer Open the ORCID record for Matthew P. Shearer [Opens in a new window]  and
Angela Vasa Open the ORCID record for Angela Vasa [Opens in a new window]
...Show all authors
Jocelyn J. Herstein*
Affiliation:
University of Nebraska Medical Center, Omaha, Nebraska, United States
Timo Wolf
Affiliation:
University Hospital Frankfurt, Frankfurt am Main, Germany
Emanuele Nicastri
Affiliation:
National Institute for Infectious Diseases “Lazzaro Spallanzani” IRCCS, Rome, Italy
Yee Sin Leo
Affiliation:
National Centre for Infectious Diseases, Singapore
Poh Lian Lim
Affiliation:
National Centre for Infectious Diseases, Singapore
Michael Jacobs
Affiliation:
Royal Free NHS Foundation Trust, London, United Kingdom
Sharon Vanairsdale
Affiliation:
Emory University, Atlanta, Georgia, United States
Eric Toner
Affiliation:
Johns Hopkins University, Baltimore, Maryland, United States
Matthew P. Shearer
Affiliation:
Johns Hopkins University, Baltimore, Maryland, United States
Angela Vasa
Affiliation:
Nebraska Medicine, Omaha, Nebraska, United States
Vikram Mukherjee
Affiliation:
NYC Health + Hospitals/Bellevue, New York City, New York, United States
Andrea Echeverri
Affiliation:
NYC Health + Hospitals/Bellevue, New York City, New York, United States
Erica S. Shenoy
Affiliation:
Massachusetts General Hospital, Boston, Massachusetts, United States
John J. Lowe
Affiliation:
University of Nebraska Medical Center, Omaha, Nebraska, United States
*
Author for correspondence: Jocelyn J. Herstein, E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective:

To assess experience, physical infrastructure, and capabilities of high-level isolation units (HLIUs) planning to participate in a 2018 global HLIU workshop hosted by the US National Emerging Special Pathogens Training and Education Center (NETEC).

Design:

An electronic survey elicited information on general HLIU organization, operating costs, staffing models, and infection control protocols of select global units.

Setting and participants:

The survey was distributed to site representatives of 22 HLIUs located in the United States, Europe, and Asia; 19 (86%) responded.

Methods:

Data were coded and analyzed using descriptive statistics.

Results:

The mean annual reported budget for the 19 responding units was US$484,615. Most (89%) had treated a suspected or confirmed case of a high-consequence infectious disease. Reported composition of trained teams included a broad range of clinical and nonclinical roles. The mean number of HLIU beds was 6.37 (median, 4; range, 2–20) for adults and 4.23 (median, 2; range, 1–10) for children; however, capacity was dependent on pathogen.

Conclusions:

Responding HLIUs represent some of the most experienced HLIUs in the world. Variation in reported unit infrastructure, capabilities, and procedures demonstrate the variety of HLIU approaches. A number of technical questions unique to HLIUs remain unanswered related to physical design, infection prevention and control procedures, and staffing and training. These key areas represent potential focal points for future evidence and practice guidelines. These data are important considerations for hospitals considering the design and development of HLIUs, and there is a need for continued global HLIU collaboration to define best practices.

Type
Original Article
Information
Infection Control & Hospital Epidemiology , Volume 43 , Issue 11 , November 2022 , pp. 1679 - 1685
Check for updates
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

a

Senior authors of equal contribution.

References

High-consequence infectious diseases. UK government website. https://www.gov.uk/guidance/high-consequence-infectious-diseases-hcid. Published 2015. Accessed April 8, 2021.Google Scholar
Chevalier, MS, Chung, W, Smith, J, et al. Ebola virus disease cluster in the United States—Dallas County, Texas, 2014 Morb Mortal Wkly Rep 2014;63:1087–1088.Google ScholarPubMed
Lopaz, MA, Amela, C, Ordobas, M, et al. First secondary case of Ebola outside November: epidemiological characteristics and contact monitoring, Spain, November to November 2014. Euro Surveill 2015;20. doi: 10.2807/1560-7917.es2015.20.1.21003.Google ScholarPubMed
Tsergouli, K, Karampatakis, T, Haidich, AB, Metallidis, S, Papa, A. Nosocomial infections caused by Crimean–Congo haemorrhagic fever virus. J Hosp Infect 2020;105:43–52.CrossRefGoogle ScholarPubMed
Cheng, VC, Chan, JF, To, KK, Yuen, KY. Clinical management and infection control of SARS: lessons learned. Antiviral Res 2013;100:407–419.CrossRefGoogle ScholarPubMed
Hui, DS, Azhar, EI, Kim, YJ, Memish, ZA, Oh, MD, Zumla, A. Middle East respiratory syndrome coronavirus: risk factors and determinants of primary, household, and nosocomial transmission. Lancet Infect Dis 2018;18:e217–e227.CrossRefGoogle ScholarPubMed
Bannister, B, Puro, V, Fusco, FM, et al. Framework for the design and operation of high-level isolation units: consensus of the european network of infectious diseases. Lancet Infect Dis 2009;9:45–56.Google ScholarPubMed
Smith, PW, Anderson, AO, Christopher, GW, et al. Designing a biocontainment unit to care for patients with serious communicable diseases: a consensus statement. Biosecur Bioterror 2006;4:351–365.Google ScholarPubMed
Cieslak, TJ, Kortepeter, MG. A brief history of biocontainment. Curr Treat Options Infect Dis 2016;8:251–258.CrossRefGoogle ScholarPubMed
Brouqui, P, Puro, V, Fusco, FM, et al. Infection control in the management of highly pathogenic infectious diseases: consensus of the european network of infectious disease. Lancet Infect Dis 2009;9:301–311.CrossRefGoogle ScholarPubMed
Kratochvil, CJ, Evans, L, Ribner, BS, et al. The national ebola training and education center: Preparing the united states for ebola and other special pathogens. Health Secur 2017;15: 253–260.CrossRefGoogle ScholarPubMed
Herstein, JJ, Biddinger, PD, Gibbs, SG, et al. Sustainability of high-level isolation capabilities among US ebola treatment centers. Emerg Infect Dis 2017;23:965–967.CrossRefGoogle ScholarPubMed
Baka, A, Fusco, FM, Puro, V, et al. A curriculum for training healthcare workers in the management of highly infectious diseases. Euro Surveill 2007;12(6):E5–E6.CrossRefGoogle ScholarPubMed
Herstein, JJ, Biddinger, PD, Kraft, CS, et al. Current capabilities and capacity of Ebola treatment centers in the United States. Infect Control Hosp Epidemiol 2016;37:313–318.CrossRefGoogle ScholarPubMed
Hewlett, AL, Varkey, JB, Smith, PW, Ribner, BS. Ebola virus disease: preparedness and infection control lessons learned from two biocontainment units. Curr Opin Infect Dis 2015;28:343–348.CrossRefGoogle ScholarPubMed
Kogutt, BK, Sheffield, JS, Whyne, D, et al. Simulation of a spontaneous vaginal delivery and neonatal resuscitation in a biocontainment unit. Health Secur 2019;17:18–26.CrossRefGoogle Scholar
Cieslak, TJHJ. A methodology for determining which diseases warrant care in a high-level containment care unit. Viruses 2019;11:773.CrossRefGoogle Scholar
Herstein, JJ, Le, AB, McNulty, LA, et al. An update on US Ebola treatment center personnel management and training. Am J Infect Control 2020;48:375–379.CrossRefGoogle ScholarPubMed
Supplementary material: PDF

Herstein et al. supplementary material

Herstein et al. supplementary material

Download Herstein et al. supplementary material(PDF)
PDF 429.3 KB