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Association between a rapid diagnostic test to detect methicillin-resistant Staphylococcus Aureus pneumonia and decreased vancomycin use in a medical intensive care unit over a 30-month period

Published online by Cambridge University Press:  01 February 2021

Chiagozie I. Pickens Open the ORCID record for Chiagozie I. Pickens [Opens in a new window] ,
Chao Qi ,
Michael Postelnick ,
Joseph Paonessa ,
Helen K. Donnelly  and
Richard G. Wunderink
Chiagozie I. Pickens*
Affiliation:
Pulmonary and Critical Care Division, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois
Chao Qi
Affiliation:
Department of Pathology, Northwestern Memorial Hospital, Chicago, Illinois Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois
Michael Postelnick
Affiliation:
Department of Pharmacy, Northwestern Memorial Hospital, Chicago, Illinois
Joseph Paonessa
Affiliation:
Pulmonary and Critical Care Division, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois
Helen K. Donnelly
Affiliation:
Pulmonary and Critical Care Division, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois
Richard G. Wunderink*
Affiliation:
Pulmonary and Critical Care Division, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois
*
Author for correspondence: Chiagozie I Pickens, E-mail: [email protected]. Or Richard G. Wunderink, E-mail: [email protected]
Author for correspondence: Chiagozie I Pickens, E-mail: [email protected]. Or Richard G. Wunderink, E-mail: [email protected]
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Abstract

Vancomycin overuse is common, yet few data are available regarding how to improve stewardship of this antibiotic. We identify an association between use of a PCR assay to rule out MRSA pneumonia and a significant, sustained decrease in average vancomycin days of therapy over a 30-month period.

Type
Concise Communication
Information
Infection Control & Hospital Epidemiology , Volume 42 , Issue 11 , November 2021 , pp. 1385 - 1387
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Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America

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References

Rubinstein, E, Kollef, MH, Nathwani, D, et al. Pneumonia caused by methicillin-resistant Staphylococcus aureus. Clin Infect Dis 2008;46:378–385 10.1086/533594CrossRefGoogle ScholarPubMed
Jones, BE, Ying, J, Stevens, V, et al. Empirical Anti-MRSA vs standard antibiotic therapy and risk of 30-day mortality in patients hospitalized for pneumonia. JAMA Intern Med 2020;180:552–560.CrossRefGoogle ScholarPubMed
Tong, SYC, Lye, DC, Yahav, D, et al. Effect of vancomycin or daptomycin with vs without an antistaphylococcal β-lactam on mortality, bacteremia, relapse, or treatment failure in patients with MRSA bacteremia: a randomized clinical trial. JAMA 2020;323:527–537.10.1001/jama.2020.0103CrossRefGoogle ScholarPubMed
Paonessa, JR, Shah, RD, Pickens, CI, et al. Rapid detection of methicillin-resistant Staphylococcus aureus in BAL: a pilot randomized controlled trial. Chest 2019;155:999–1007.10.1016/j.chest.2019.02.007CrossRefGoogle ScholarPubMed
Bauer, KA, Perez, KK, Forrest, GN, et al. Review of rapid diagnostic tests used by antimicrobial stewardship programs. Clin Infect Dis 2014;59:134–140.CrossRefGoogle ScholarPubMed