Hostname: page-component-cd9895bd7-hc48f Total loading time: 0 Render date: 2024-12-25T18:22:54.450Z Has data issue: false hasContentIssue false

Zigzag: a genetic defect of the horizontal canals in the mouse

Published online by Cambridge University Press:  14 April 2009

Mary F. Lyon
Affiliation:
Medical Research Council Radiobiological Research Unit, Harwell, Berkshire, England
Rights & Permissions [Opens in a new window]

Extract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The name zigzag has been given to an inherited behaviour defect in the mouse in which the animals walk with a zigzag motion. It is inherited polygenically. The anatomical defect responsible for the abnormal behaviour was a reduction or absence of the horizontal canals of the inner ear, the reduction consisting of a constriction in the middle of the canal length, rather than a shortening of the canal.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1960

References

REFERENCES

Danforth, C. H. (1958). The occurrence and genetic behaviour of duplicate lower incisors in the mouse. Genetics, 43, 139148.CrossRefGoogle ScholarPubMed
Dunn, L. C. & Charles, D. R. (1937). Studies on spotting patterns. I. Analysis of quantitative variations in the pied spotting of the house mouse. Genetics, 22, 1442.Google Scholar
Grüneberg, H. (1956). Hereditary lesions of the labyrinth in the mouse. Brit. med. Bull. 12, 153157.Google Scholar
Grüneberg, H. (1951). The genetics of a tooth defect in the mouse. Proc. roy. Soc. B, 138, 437451.Google Scholar
Holt, S. B. (1948). The effect of maternal age on the manifestation of a polydactyl gene in mice. Ann. Engen., Lond., 14, 144157.Google Scholar
Lyon, M. F. (1958). Twirler: a mutant affecting the inner ear of the house mouse. J. Embryol. exp. Morph. 6, 105116.Google Scholar
Reed, S. C. (1936). Harelip in the house mouse. Genetics, 21, 339374.Google Scholar
Truslove, G. M. (1956). The anatomy and development of the fidget mouse. J. Genet. 54, 6486.Google Scholar
Wright, S. (1934 a). An analysis of variability in number of digits in an inbred strain of guinea-pigs. Genetics, 19, 506536.Google Scholar
Wright, S. (1934 b). The results of crosses between inbred strains of guinea-pigs differing in number of digits. Genetics, 19, 537551.Google Scholar