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X chromosome activity in female germ cells of mice heterozygous for Searle's translocation T(X;16)16H

Published online by Cambridge University Press:  14 April 2009

P. G. Johnston
P. G. Johnston
Affiliation:
MRC Radiobiology Unit, Harwell, Oxon, 0X11 0RD, U.K.
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The expression of X-linked phosphoglycerate kinase (PGK-1) in germ cells from embryos heterozygous for both PGK-1 and Searle's translocation T(X; 16) 16H was examined to investigate X chromosome activity during oogenesis. The Pgk-lb allele on the translocated X chromosome was the only allele active in somatic cells of all embryos and in germ cells from 12·5 d.p.c. embryos. However, an additional faint band representing Pgk-la activity was observed in germ cells from older embryos (13·5–18·5 d.p.c.) and neonates (1–2 d.p.p.). It is concluded that there is a period when only one X chromosome is active in early female germ cells and that reactivation of the inactive X chromosome takes place just prior to meiotic prophase.

Type
Short Paper
Information
Genetics Research , Volume 37 , Issue 3 , June 1981 , pp. 317 - 322
Copyright
Copyright © Cambridge University Press 1981

References

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