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Why is there so little intragenic linkage disequilibrium in humans ?

Published online by Cambridge University Press:  08 June 2001

MOLLY PRZEWORSKI  and
JEFFREY D. WALL
MOLLY PRZEWORSKI
Affiliation:
Statistics Department, Oxford University, 1 South Parks Road, Oxford OX1 3TG, UK
JEFFREY D. WALL
Affiliation:
2102 Biological Laboratories, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
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Abstract

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The efficient design of association mapping studies relies on a knowledge of the rate of decay of linkage disequilibrium with distance. This rate depends on the population recombination rate, C. An estimate of C for humans is usually obtained from a comparison of physical and genetic maps, assuming an effective population size of approximately 104. We demonstrate that under both a constant population size model and a model of long-term exponential growth, there is evidence for more recombination in polymorphism data than is expected from this estimate. An important contribution of gene conversion to meiotic recombination helps to explain our observation, but does not appear to be sufficient. The occurrence of multiple hits at CpG sites and the presence of population structure are not explanations.

Type
Research Paper
Information
Genetics Research , Volume 77 , Issue 2 , February 2001 , pp. 143 - 151
Copyright
© 2001 Cambridge University Press