Hostname: page-component-586b7cd67f-dlnhk Total loading time: 0 Render date: 2024-11-28T00:18:09.862Z Has data issue: false hasContentIssue false
  • English
  • Français

Unusual behaviour of linkage disequilibrium in two-locus gene conversion models

Published online by Cambridge University Press:  14 April 2009

J. Bruce Walsh
J. Bruce Walsh
Affiliation:
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The amount of linkage of disequilibrium maintained in a two-locus infinite population model by gene conversion and recombination is examined. Intrachromosomal conversion (conversion between different loci on the same chromosome) generates positive linkage disequilibrium. Specifically, = p(1 − p) [1 − r/(γ + r − γr)], where p is the frequency of allele A at both loci, r is the recombination rate between loci and γ is the per-gamete conversion rate. Somewhat unexpectedly, interchromosomal conversion (conversion between loci on different chromosomes) also generates positive disequilibrium, albeit very small. More interestingly, the behaviour of this disequilibrium as a function of recombination is unusual. If β is the interchromosomal conversion rate between a pair of loci, then = p(1 − p) [rβ/(β+r − βr)]. increases with increasing recombination, being zero for the case of complete linkage (r = 0), and maximized at r = 1/2. This unusual behaviour can be accounted for by the generation of excess coupling gametes when an interchromosomal conversion event is followed by recombination.

Type
Research Article
Information
Genetics Research , Volume 51 , Issue 1 , February 1988 , pp. 55 - 58
Copyright
Copyright © Cambridge University Press 1988

References

Dover, G. A. (1982). Molecular drive: a cohesive model of species evolution. Nature 299, 111–117.CrossRefGoogle Scholar
Fink, G. R. & Petes, T. D. (1984). Gene conversion in the absence of reciprocal recombination. Nature 310, 728–729.CrossRefGoogle ScholarPubMed
Nagylaki, T. (1984 a). The evolution of multigate families under intrachromosomal gene conversion. Genetics 106, 529–548.CrossRefGoogle Scholar
Nagylaki, T. (1984 b). The evolution of multigene families under interchromosomal gene conversion. Proceedings of the National Academy of Sciences, USA 81, 3796–3800.CrossRefGoogle ScholarPubMed
Ohta, T. (1983). On the evolution of multigene families. Theoretical Population Biology 23, 216–240.CrossRefGoogle ScholarPubMed
Slatkin, M. (1986). Interchromosomal biased gene conversion, mutation and selection in a multigene family. Genetics 112, 681–698.CrossRefGoogle Scholar
Szostak, J. W., Orr-Weaver, T. L., Rothstein, R. J. & Stahl, F. W. (1983). The double-strand-break repair model for recombination. Cell 33, 25–35.CrossRefGoogle ScholarPubMed