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Tipsy, a new mutant in linkage group VII of the mouse

Published online by Cambridge University Press:  14 April 2009

A. G. Searle
A. G. Searle
Affiliation:
Medical Research Council Radiobiological Research Unit, Harwell, Berkshire, England
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Tipsy (symbol ti) is a fully penetrant recessive mutant in linkage group VII of the mouse. Homozygotes have a peculiar rabbit-like gait from the age of a week, followed soon after by a tendency for the fore-part of the body to sway from side to side, leading to a reeling locomotion with falling over in severely affected mice. There is marked variation in manifestation and some amelioration in older animals; both sexes are fertile.

Linkage relationships in group VII are discussed and tipsy is compared with other mutants showing locomotor instability.

Type
Research Article
Information
Genetics Research , Volume 2 , Issue 1 , February 1961 , pp. 122 - 126
Copyright
Copyright © Cambridge University Press 1961

References

REFERENCES

Carter, T. C. (1951). Wavy-coated mice: phenotypic interactions and linkage tests between Rex and (a) waved-1, (b) waved-2. J. Genet. 50, 268–276.CrossRefGoogle Scholar
Carter, T. C. (1957). Private communication. Mouse News Letter, 16, 15.Google Scholar
Carter, T. C. (1958). Private communication. Mouse News Letter, 18, 37.Google Scholar
Carter, T. C. & Phillips, R. J. S. (1953). The sex distribution of waved-2, shaker-2 and Rex in the house mouse. Z. indukt. Abstamm.- u. Vererb Lehre. 85, 564–578.Google ScholarPubMed
Dickie, M. M. (1955). Alopecia, a dominant mutation in the house mouse. J.Hered. 46, 31–34.CrossRefGoogle Scholar
Dickie, M. M., Scheider, J. & Harman, P. J. (1952). A juvenile Wabbler-lethal in the house mouse. J. Hered. 43, 283–286.CrossRefGoogle Scholar
Falconer, D.S. (1947). Linkage of Rex with shaker-2 in the house mouse. Heredity, 1, 133–135.CrossRefGoogle Scholar
Falconer, D. S. (1951). Two new mutants, ‘Trembler’ and ‘reeler’, with neurological actions in the house mouse. J. Genet. 50, 192–201.CrossRefGoogle ScholarPubMed
Falconer, D. S. & Sobey, W. R. (1953). The location of trembler in linkage group VII of the house mouse. J. Hered. 49, 159–160.CrossRefGoogle Scholar
Green, M. C. & Dickie, M. M. (1959). Linkage map of the mouse. J. Hered. 50, 3–5.CrossRefGoogle Scholar
Grüneberg, H. (1952). The Genetics of the Mouse, 2nd edn.The Hague, Martinus Nijhoff.Google Scholar
Grüneberg, H. (1956). An annotated catalogue of the mutant genes of the house mouse. M.R.C. Memo. No. 33, London, H.M.S.O.Google ScholarPubMed
Hoecker, G., Martinez, A., Markovic, S. & Pizzaro, O. (1954). Agitans, a mutation with neurological effects in the house mouse. J. Hered. 45, 10–14.CrossRefGoogle Scholar
Kosambi, D. D. (1944). The estimation of map distances from recombination values. Ann. Eugen., Lond., 12, 172–175.CrossRefGoogle Scholar
Lane, P. W. (1960). Personal communication.Google Scholar
Lyon, M. F. (1951). Hereditary absence of otoliths in the house mouse. J. Physiol. 114, 410–418.CrossRefGoogle ScholarPubMed
Lyon, M. F. (1955). Ataxia, a new recessive mutant of the house mouse. J. Hered. 46, 77–80.CrossRefGoogle Scholar
Mallyon, S. A. (1953). ‘Rabbit-gait’ in the house mouse. Nature, Lond., 172, 312.CrossRefGoogle Scholar
Michie, D. (1952). A new linkage in the house mouse: vestigial and rex. Nature, Lond., 170, 585–587.CrossRefGoogle ScholarPubMed
Michie, D. (1955). Genetical studies with ‘vestigial tail’ mice. II. The position of vestigial in the seventh linkage group. J. Genet. 53, 280–284.CrossRefGoogle Scholar
Sirlin, J. L. (1956). Vacillans, a neurological mutant in the house mouse linked with brown. J. Genet. 54, 42–48.CrossRefGoogle Scholar
Snell, G. D. (1955). Ducky, a new second chromosome mutation in the mouse. J. Hered. 46, 27–29.CrossRefGoogle Scholar
Wright, M. E. (1947). Two sex-linkages in the mouse with unusual recombination values. Heredity, 1, 349–354.CrossRefGoogle Scholar
Yoon, C. H. (1959). Waddler, a new mutation, and its interaction with quivering. J. Hered. 50, 238–244.CrossRefGoogle Scholar
Yoon, C. H. & Les, E. P. (1957). Quivering, a new first chromosome mutation in mice. J. Hered. 48, 176–180.CrossRefGoogle Scholar