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Time of initiation and site of action of the mouse chromosome 11 imprinting effects

Published online by Cambridge University Press:  14 April 2009

Bruce M. Cattanach ,
Colin V. Beechey ,
Carol Rasberry ,
Janet Jones  and
David Papworth
Bruce M. Cattanach*
Affiliation:
MRC Mammalian Genetics Unit Harwell, Didcot, Oxfordshire OX11 ORD, UK
Colin V. Beechey
Affiliation:
MRC Mammalian Genetics Unit Harwell, Didcot, Oxfordshire OX11 ORD, UK
Carol Rasberry
Affiliation:
MRC Mammalian Genetics Unit Harwell, Didcot, Oxfordshire OX11 ORD, UK
Janet Jones
Affiliation:
MRC Mammalian Genetics Unit Harwell, Didcot, Oxfordshire OX11 ORD, UK
David Papworth
Affiliation:
MRC Mammalian Genetics Unit Harwell, Didcot, Oxfordshire OX11 ORD, UK
*
* Corresponding author.
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Previous studies have shown that mice with paternal disomy for chromosome 11 are consistently larger at birth than their normal sibs, whereas mice with the maternal disomy are consistently smaller. An imprinting effect with monoallelic expression of some gene/s affecting growth was indicated. Here we show that the size differences become established prior to birth and are only maintained subsequently, indicating that the gene repression is limited to prenatal development. Fetal analysis was limited to 12·5–17·5 days post coitum. However by extrapolating the data backwards it could be calculated that both the maternal and paternal size effects might commence as early as 7 days post coitum, although possibly slightly later. It may be deduced that initiation of expression of the gene/s responsible may occur at about this time in development. The two disomy growth rates were mirror-images of each other, suggesting that expressed gene dosage is the underlying cause. Differential growth of the placentas of the two disomies was also found, and extrapolation of these data backwards suggested that the placental size differences were initiated later in development than those for the fetuses. The differential placental growth of the maternal and paternal disomies may therefore have developed independently or emerged as a consequence of the differential fetal growth. In either event it would seem that the expression of the responsible gene occurs in the fetus itself to cause the anomalies of growth. The data therefore provide information on the temporal and tissue specificity of the gene/s responsible for the chromosome 11 imprinting effects. Possible candidate genes are discussed.

Type
Research Article
Information
Genetics Research , Volume 68 , Issue 1 , August 1996 , pp. 35 - 43
Copyright
Copyright © Cambridge University Press 1996

References

Adler, I. -D., Schriever-Schwemmer, G. & Kliesch, U. (1994). Clastogenicity of trophosphamide in somatic and germinal cells of mice. Mutation Research. 307, 237–243.Google Scholar
Barlow, D. P., Stoger, R., Herrmann, B. G., Saito, K. & Schweifer, N. (1991). The mouse insulin-like growth factor type-2 receptor is imprinted and closely linked to the Tme locus. Nature 349, 84–87.CrossRefGoogle Scholar
Bartke, A. (1965). The response of two types of dwarf mice to growth hormone, thyorotropin and thyroxine. General Comparative Endocrinology. 5, 418–426.CrossRefGoogle ScholarPubMed
Bartolomei, M. S., Zemel, S. & Tilghman, S. M. (1991). Parental imprinting of the mouse H19 gene. Nature 351, 153–155.Google Scholar
Beechey, C. V. (1989). Fate of nullisomy and tetrosomy 11 embryos. Mouse News Letter 84, 83–84.Google Scholar
Beechey, C. V. & Cattanach, B. M. (1995). Genetic imprinting map. Mouse Genome 93, 89–92.Google Scholar
Cattanach, B. M. (1986). Parental origin effects in mice. Journal of Embryology and Experimental Morphology 97, 137–150.Google ScholarPubMed
Cattanach, B. M. (1991). Chromosome imprinting and its significance for mammalian development. In Genome Analysis, vol. 2, Gene Expression and its Control (ed. Davies, K. & Tighlman, S.), pp. 41–71. Cold Spring Harbour, NY: Cold Spring Harbor Laboratory Press.Google Scholar
Cattanach, B. M. & Jones, J. (1994). Genetic imprinting in the mouse: implications for gene regulation. Journal of Inherited Metabolic Disease 17, 403–420.CrossRefGoogle ScholarPubMed
Cattanach, B. M. & Kirk, M. (1985). Differential activity of maternally and paternally derived chromosome regions in mice. Nature 315, 496–498.Google Scholar
Cattanach, B. M. & Moseley, H. (1973). Nondisjunction and reduced fertility caused by the tobacco mouse metacentric chromosomes. Cytogenetics and Cell Genetics 12, 264–287.Google Scholar
DeChiara, T. M., Robertson, E. J. & Efstratiadis, A. (1991). Parental imprinting of the mouse insulin-like growth factor II gene. Cell 64, 849–859.CrossRefGoogle ScholarPubMed
Ferguson-Smith, A. C., Cattanach, B. M., Barton, S. C., Beechey, C. V. & Surani, M. A. (1991). Embryological and molecular investigations of parental imprinting on mouse chromosome 7. Nature 351, 667–670.Google Scholar
Giddings, S. J., King, C. D., Harman, K. W., Flood, J. F. & Carnaghi, L. R. (1994). Allele specific inactivation of insulin 1 and 2, in the mouse yolk sac, indicates imprinting. Nature Genetics 6, 310–313.CrossRefGoogle ScholarPubMed
Gropp, A., Kolbus, U. & Giers, D. (1975)- Systematic approach to the study of trisomy in the mouse: II. Cytogenetics and Cell Genetics 14, 42–62.CrossRefGoogle Scholar
Grüneberg, H. (1957). Genetical studies on the skeleton of the mouse. Journal of Genetics 55, 181–194.Google Scholar
Guillemot, F., Caspary, T., Tighlman, S. M., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Anderson, D. J., Joyner, A. L., Rossant, J. & Nagy, A. (1995). Genomic imprinting of Mash2, a mouse gene required for trophoblast development. Nature Genetics 9, 235–242.Google ScholarPubMed
Hatada, I., Sugama, T. & Mukai, T. (1993). A new imprinted gene cloned by a methylation-sensitive genome scanning method. Nucleic Acids Research 21, 5577–5582.Google Scholar
Hatada, U. & Mukai, T. (1995). Genomic imprinting of p57KIP2, a cyclin-dependent kinase inhibitor, in mouse. Nature Genetics 11, 204–206.Google Scholar
Hayashizaki, Y., Shibata, H., Hirotsune, S., Sugino, H., Okazaki, Y., Sasaki, N., Hirose, K., Imoto, H., Okuizumi, H., Muramatsu, M., Komatusbara, H., Shiroishi, T., Moriwaki, K., Katsuki, M., Hatano, N., Sasaki, H., Ueda, T., Mise, N., Takagi, N., Pass, C. & Chapman, V. M. (1994). Identification of an imprinted U2af binding protein related sequence on mouse chromosome 11 using the RLGS method. Nature Genetics 6, 33–40.Google Scholar
Kaneko-Ischino, T., Kuroiwa, Y., Miyoshi, N., Kohda, T., Suzuki, R., Yokoyama, M., Viville, S., Barton, S. C., Ishino, F. & Surani, M. A. (1995). Pegl'mest imprinted gene on chromosome 6 identified by cDNA subtraction hybridisation. Nature Genetics 11, 52–59.Google Scholar
Leff, S. E., Brannan, C. I., Reed, M. L., Ozcelik, T., Francke, U., Copeland, N. G. & Jenkins, N. A. (1992). Maternal imprinting of the mouse Snrpn gene and conserved linkage homology with Prader-Willi syndrome region of humans. Nature Genetics 2, 259–264.CrossRefGoogle Scholar
Lyon, M. F. & Kirby, M. C. (1995). Mouse chromosome atlas. Mouse Genome 93, 23–66.Google Scholar
McLaren, A. (1975). Growth from fertilization to birth in the mouse. In Embryogenesis in Mammals. CIBA Symposium 40, 47–51.Google Scholar
Oakley, R. J., Matheson, P. G., Litwin, S., Tilghman, S. M. & Nussbaum, R. L. (1995). Nondisjunction rates and abnormal embryonic development in a mouse cross between heterozygotes carrying a (7,18) Robertsonian translocation chromosome. Genetics 141, 667–674.CrossRefGoogle Scholar
Searle, A. G. & Beechey, C. V. (1990). Genome imprinting phenomena on mouse chromosome 7. Genetical Research 56, 237–244.Google Scholar
Solter, D. (1988). Differential imprinting and expression of maternal and paternal genomes. Annual Review of Genetics 22, 127–146.Google Scholar
Surani, M. A. (1991). Genomic imprinting: developmental significance and molecular mechanism. Current Opinion in Genetics and Development 1, 241–246.CrossRefGoogle ScholarPubMed
Villar, A. J. & Pedersen, R. A. (1994). Parental imprinting of the Mas protooncogene in mouse. Nature Genetics 8, 373–379.Google Scholar