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The time of detection of sex-linked recessives in small populations

Published online by Cambridge University Press:  14 April 2009

J. W. James
J. W. James
Affiliation:
Station de Génétique Quantitative et Appliquée, Centre National de Recherches Zootechniques, I.N.R.A., Jouy-en-Josas, France
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Summary

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A sex-linked recessive gene with visible effect will first be detected in the hemizygous sex (male). In lines with equal numbers of males and females, when the gene is initially present in a single female the probabifity of detection falls from 2/3 in single pair lines to 0·54 in large lines. The mean and standard deviation of time to detection are almost independent of population size, being about 4/3 and 2/3 respectively. About 98% of all detections occur within three generations, so a gene detected much later than this after the foundation of a selection line is likely to be a new mutant. Higher initial frequencies and selection favouring heterozygotes increase the chance of detection. The time taken is decreased with higher initial frequencies and increased slightly by selection favouring heterozygotes.

Type
Research Article
Information
Genetics Research , Volume 34 , Issue 1 , August 1979 , pp. 11 - 17
Copyright
Copyright © Cambridge University Press 1979

References

REFERENCE

Robertson, A. (1978). The time of detection of recessive visible genes in small populations. Genetical Research 31, 255–264.CrossRefGoogle Scholar