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Three genes determine the carboxin sensitivity of mitochondrial succinate oxidation in Aspergillus nidulans

Published online by Cambridge University Press:  14 April 2009

I. A. U. N. Gunatilleke ,
H. N. Arst Jr  and
C. Scazzocchio
I. A. U. N. Gunatilleke
Affiliation:
Department of Genetics, University of Cambridge, Milton Road, Cambridge CB4 1XH, England
H. N. Arst Jr*
Affiliation:
Department of Genetics, University of Cambridge, Milton Road, Cambridge CB4 1XH, England
C. Scazzocchio
Affiliation:
Department of Genetics, University of Cambridge, Milton Road, Cambridge CB4 1XH, England
*
† Address correspondence to this author.
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Summary

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Partially dominant mutations to carboxin resistance occur in three, freely recombining, nuclear genes in Aspergillus nidulans. Mutations at all three loci reduce carboxin inhibition of succinate dehydrogenase (EC 1.3.99.1), succinate-cytochrome c reductase (EC 1.3.99.1) and succinate oxidase (EC 1.3.99.1) in mitochondrial preparations. It is therefore probable that the ability of carboxin to prevent growth of A. nidulans is a direct consequence of its ability to prevent succinate oxidation.

Type
Research Article
Information
Genetics Research , Volume 26 , Issue 3 , December 1975 , pp. 297 - 305
Copyright
Copyright © Cambridge University Press 1975

References

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