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Sex differences in fitness and selection for centric fusions between sex-chromosomes and autosomes

Published online by Cambridge University Press:  14 April 2009

D. Charlesworth  and
B. Charlesworth
D. Charlesworth
Affiliation:
School of Biological Sciences, University of Sussex, Brighton BN1 9QG, England
B. Charlesworth
Affiliation:
School of Biological Sciences, University of Sussex, Brighton BN1 9QG, England
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Summary

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A model of centric fusions between the X or Y chromosome and an autosome carrying a selected locus is studied. It is assumed that fusions are not associated with any fitness effects, and that all chromosomes disjoin regularly from their homologues. It is shown that a necessary condition for the fusion to be favoured is that there is a selectively maintained sex difference in allele frequencies at the selected locus. If this condition is satisfied, the initial rate of increase of a rare Y-autosome fusion is about three times that of an X-autosome fusion, with the same parameter values. Computer calculations of the final equilibrium states reached by populations containing such fusions were done.

Type
Research Article
Information
Genetics Research , Volume 35 , Issue 2 , April 1980 , pp. 205 - 214
Copyright
Copyright © Cambridge University Press 1980

References

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